Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Alexander R, Dunn"'
Autor:
Amani A. Hariri, Sharon S. Newman, Steven Tan, Dan Mamerow, Alexandra M. Adams, Nicolò Maganzini, Brian L. Zhong, Michael Eisenstein, Alexander R. Dunn, H. Tom Soh
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
A major challenge of enzyme-linked immunosorbent assays is discriminating true signal from non-specific binding. Here the authors present a Single-Molecule Colocalization Assay (SiMCA) which eliminates such effects, enabling reproducible detection of
Externí odkaz:
https://doaj.org/article/18c976fb74b244c38652006166953114
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Dynamic remodeling of the actin cytoskeleton underlies cell movement, but is challenging to characterize at the molecular level. Here, the authors present a method to extract actin filament velocities in living cells, and compare their results to cur
Externí odkaz:
https://doaj.org/article/092a1b4dbe2344f5bb7cf462cfe8bef5
Autor:
Jia-Yang Chen, Hsu-Huan Chou, Syer Choon Lim, Yen-Jang Huang, Kuan-Chen Lai, Chin-Lin Guo, Chien-Yi Tung, Chung-Tsai Su, Jocelyn Wang, Edward Liu, Hsiao-Fen Han, Po-Ying Yeh, Chun-Mei Hu, Alexander R. Dunn, Curtis W. Frank, Yi-Chun Wu, Muh-Hwa Yang, Ying-Chih Chang
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105081- (2022)
Summary: Matching the treatment to an individual patient’s tumor state can increase therapeutic efficacy and reduce tumor recurrence. Circulating tumor cells (CTCs) derived from solid tumors are promising subjects for theragnostic analysis. To anal
Externí odkaz:
https://doaj.org/article/acd41be305f7427ba525ce84c75cae56
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The formation of a hollow lumen surrounded by cells is a key developmental process that sets the shape of tissues and organs. Here, the authors show how the combined influence of geometric constraints imposed by cell packing and osmotic pressure can
Externí odkaz:
https://doaj.org/article/114c674fd5ef4820af612699a1723983
Publikováno v:
Cell Reports: Methods, Vol 2, Iss 9, Pp 100278- (2022)
Summary: Numerous proteins experience and respond to mechanical forces as an integral part of their cellular functions, but measuring these forces remains a practical challenge. Here, we present a compact, 11-kDa molecular tension sensor termed STReT
Externí odkaz:
https://doaj.org/article/13e63ac92d9c4dd98aff36435b79d1cd
Publikováno v:
eLife, Vol 11 (2022)
Mechanotransduction at cell–cell adhesions is crucial for the structural integrity, organization, and morphogenesis of epithelia. At cell–cell junctions, ternary E-cadherin/β-catenin/αE-catenin complexes sense and transmit mechanical load by bi
Externí odkaz:
https://doaj.org/article/80a4b43fb8f14c01bd30aa1397f85393
Autor:
Aidan M. Tousley, Maria Caterina Rotiroti, Louai Labanieh, Lea Wenting Rysavy, Won-Ju Kim, Caleb Lareau, Elena Sotillo, Evan W. Weber, Skyler P. Rietberg, Guillermo Nicolas Dalton, Yajie Yin, Dorota Klysz, Peng Xu, Eva L. de la Serna, Alexander R. Dunn, Ansuman T. Satpathy, Crystal L. Mackall, Robbie G. Majzner
Publikováno v:
Nature. 615:507-516
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89299b7d211d80ffb693266aaf4e3756
https://doi.org/10.1038/s41586-023-05778-2
https://doi.org/10.1038/s41586-023-05778-2
Autor:
Wei Kan, Michael D Enos, Elgin Korkmazhan, Stefan Muennich, Dong-Hua Chen, Melissa V Gammons, Mansi Vasishtha, Mariann Bienz, Alexander R Dunn, Georgios Skiniotis, William I Weis
Publikováno v:
eLife, Vol 9 (2020)
In Wnt/β-catenin signaling, the transcriptional coactivator β-catenin is regulated by its phosphorylation in a complex that includes the scaffold protein Axin and associated kinases. Wnt binding to its coreceptors activates the cytosolic effector D
Externí odkaz:
https://doaj.org/article/909d22a097d24da0a1d1f2431d614ce4
Autor:
Andrew J. Price, Anna-Lena Cost, Hanna Ungewiß, Jens Waschke, Alexander R. Dunn, Carsten Grashoff
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Desmosomes are intercellular adhesion complexes that connect the intermediate filament cytoskeletons of neighboring cells but direct evidence for their load-bearing nature is lacking. Here the authors develop FRET-based tension sensors to measure the
Externí odkaz:
https://doaj.org/article/2215fbe56cc84a20a528fc6fe6ae67ab
Autor:
Dhiraj Indana, Andrei Zakharov, Youngbin Lim, Alexander R. Dunn, Nidhi Bhutani, Vivek B. Shenoy, Ovijit Chaudhuri
SummaryLumens or fluid-filled cavities are a ubiquitous feature of mammals and are often evolutionarily linked to the origin of body-plan complexity. Post-implantation, the pluripotent epiblast in a human embryo forms a central lumen, paving the way
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa139354f21386eeeb959ad2ff3ed658
https://doi.org/10.1101/2023.04.20.537711
https://doi.org/10.1101/2023.04.20.537711
