Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Alexander Polemeropoulos"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5078-5082
We designed and synthesized a series of novel 3,6-bicyclolide oximes, possessing linkers of varying lengths to the secondary binding site. The E isomers exhibited excellent antibacterial profiles against a broad spectrum of resistant pathogens.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52923a0dbe11c44a0b0da894047d00ff
https://doi.org/10.1016/j.bmcl.2008.07.118
https://doi.org/10.1016/j.bmcl.2008.07.118
Autor:
Guoyou Xu, Zhe Wang, Datong Tang, Alexander Polemeropoulos, Yat Sun Or, Yonghua Gai, Zhigang Chen
Publikováno v:
ChemInform. 40
The synthesis of 3,6-bicyclolides from erythromycin A oxime is described. This novel class of bridged bicyclic macrolides demonstrates potent in vitro and in vivo activities against a broad spectrum of bacteria including resistant respiratory tract p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::460558a9afc7038e5efd25eb06278970
https://doi.org/10.1002/chin.200916201
https://doi.org/10.1002/chin.200916201
Autor:
Deqiang Niu, Yao-Ling Qiu, Guoqiang Wang, Zhigang Chen, Alexander Polemeropoulos, Ly Tam Phan, Yat Sun Or
Publikováno v:
ChemInform. 36
A bridging chemistry process was developed to form an ether bridge between 6-O and 11-O of erythromycin A via a tandem or stepwise palladium-catalyzed bis-pi-allylation. By applying this bridging process, new 6,11-O-bridged bicyclic ketolides (BBKs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38fac07806614335138f7c275ba319c4
https://doi.org/10.1002/chin.200514214
https://doi.org/10.1002/chin.200514214