Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Alexander Pavlovsky"'
Autor:
Yunmei Wang, Huiyun Gao, Can Shi, Paul W. Erhardt, Alexander Pavlovsky, Dmitry A. Soloviev, Kamila Bledzka, Valentin Ustinov, Liang Zhu, Jun Qin, Adam D. Munday, Jose Lopez, Edward Plow, Daniel I. Simon
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The binding of the leukocyte integrin Mac1 to the platelet receptor GPIbα is important for the physiological response to tissue injury. Here the authors show that this interaction also regulates thrombosis, without influencing bleeding time, which m
Externí odkaz:
https://doaj.org/article/fde7eceb216348f28d8514ea1e616f3d
Autor:
Yunmei Wang, Huiyun Gao, Can Shi, Paul W. Erhardt, Alexander Pavlovsky, Dmitry A. Soloviev, Kamila Bledzka, Valentin Ustinov, Liang Zhu, Jun Qin, Adam D. Munday, Jose Lopez, Edward Plow, Daniel I. Simon
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 8: Article number:15559 (2017); Published 30 May 2017; Updated 4 July 2017 The original version of this Article contained an error in the email address of the corresponding author Daniel I. Simon. The correct email is Daniel.Sim
Externí odkaz:
https://doaj.org/article/aec6ecbcaca9430582897409a185d07d
Autor:
Valentin Ustinov, Yunmei Wang, Can Shi, Daniel I. Simon, Dmitry A. Soloviev, Alexander Pavlovsky, José A. López, Edward F. Plow, Paul W. Erhardt, Huiyun Gao, Kamila Bledzka, Adam D. Munday, Jun Qin, Liang Zhu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications
Nature Communications
Inflammation and thrombosis occur together in many diseases. The leukocyte integrin Mac-1 (also known as integrin αMβ2, or CD11b/CD18) is crucial for leukocyte recruitment to the endothelium, and Mac-1 engagement of platelet GPIbα is required for
Autor:
Yunmei, Wang, Huiyun, Gao, Can, Shi, Paul W, Erhardt, Alexander, Pavlovsky, Dmitry A, Soloviev, Kamila, Bledzka, Valentin, Ustinov, Liang, Zhu, Jun, Qin, Adam D, Munday, Jose, Lopez, Edward, Plow, Daniel I, Simon
Publikováno v:
Nature Communications
Inflammation and thrombosis occur together in many diseases. The leukocyte integrin Mac-1 (also known as integrin αMβ2, or CD11b/CD18) is crucial for leukocyte recruitment to the endothelium, and Mac-1 engagement of platelet GPIbα is required for
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 70:442-450
S-Adenosylmethionine (AdoMet) participates in a wide range of methylation and other group-transfer reactions and also serves as the precursor for two groups of quorum-sensing molecules that function as regulators of the production of virulence factor
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:2950-2956
Microbes that have gained resistance against antibiotics pose a major emerging threat to human health. New targets must be identified that will guide the development of new classes of antibiotics. The selective inhibition of key microbial enzymes tha
Autor:
Alexander Pavlovsky, Julio Blanco, Buenafe T. Arachea, Christopher R. Faehnle, Ronald E. Viola, Xuying Liu, Roger A. Moore
Publikováno v:
Journal of Amino Acids
The aspartate pathway of amino acid biosynthesis is essential for all microbial life but is absent in mammals. Characterizing the enzyme-catalyzed reactions in this pathway can identify new protein targets for the development of antibiotics with uniq
Publikováno v:
Chemical Biology & Drug Design. 79:128-136
The aspartate biosynthetic pathway is found only in plants and microbes. The commitment step to this pathway is the phosphorylation of aspartic acid catalyzed by aspartokinases (1). The next enzyme, aspartate-β-semialdehyde dehydrogenase (ASADH), ca
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 66:205-212
The enzyme aspartate semialdehyde dehydrogenase (ASADH) catalyzes a critical transformation that produces the first branch-point intermediate in an essential microbial amino-acid biosynthetic pathway. The first structure of an ASADH isolated from a f
Autor:
Nicole Caspers, James B. Dunbar, Alexander Pavlovsky, Robert M. Kennedy, Graeme Bainbridge, Elizabeth Bills, Melissa S. Harris, Gary Louis Bolton, Richard H. Hutchings, Larry D. Bratton, Jeffrey A. Pfefferkorn, Ronald W. Sarver, Scott D. Larsen
Publikováno v:
Journal of Medicinal Chemistry. 51:3804-3813
Clinical studies have demonstrated that statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) inhibitors, are effective at lowering mortality levels associated with cardiovascular disease; however, 2-7% of patients may experience statin-ind