Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Alexander Pautsch"'
Autor:
Tânia F. Custódio, Maxime Killer, Dingquan Yu, Virginia Puente, Daniel P. Teufel, Alexander Pautsch, Gisela Schnapp, Marc Grundl, Jan Kosinski, Christian Löw
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract PHT1 is a histidine /oligopeptide transporter with an essential role in Toll-like receptor innate immune responses. It can act as a receptor by recruiting the adaptor protein TASL which leads to type I interferon production via IRF5. Persist
Externí odkaz:
https://doaj.org/article/4be3f59ad2c440dca63059f50336a519
Autor:
Tânia Custódio, Maxime Killer, Dingquan Yu, Virginia Puente, Daniel Teufel, Alexander Pautsch, Gisela Schnapp, Marc Grundl, Jan Kosinski, Christian Loew
PHT1 is a histidine /oligopeptide transporter with an essential role in Toll-like receptor innate immune response. It can act as a receptor by recruiting the adaptor protein TASL which leads to type I interferon production via IRF5. Persistent stimul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3bcd275d43c4c1358e8c8fabc20a370
https://doi.org/10.21203/rs.3.rs-2646698/v1
https://doi.org/10.21203/rs.3.rs-2646698/v1
Autor:
Sven O. Dahms, Gisela Schnapp, Martin Winter, Frank H. Büttner, Marco Schlepütz, Christian Gnamm, Alexander Pautsch, Hans Brandstetter
Publikováno v:
ACS chemical biology. 17(4)
Inhibitors of the proprotein convertase furin might serve as broad-spectrum antiviral therapeutics. High cellular potency and antiviral activity against acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported for (3,5-dichlorophenyl)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94031702d81f07bf8302792eab924e3
https://pubmed.ncbi.nlm.nih.gov/35377598
https://pubmed.ncbi.nlm.nih.gov/35377598
Publikováno v:
Journal of Computer-Aided Molecular Design. 35:531-539
Drug discovery is an expensive and time-consuming process. To make this process more efficient quantum chemistry methods can be employed. The electrophilicity index is one property that can be calculated by quantum chemistry methods, and if calculate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2eb68618c4c32c6b9275a019d3fcf64a
https://doi.org/10.1007/s10822-020-00342-w
https://doi.org/10.1007/s10822-020-00342-w
Autor:
Alexander Pautsch, Alexander Weber, Christofer S. Tautermann, Ferruccio Palazzesi, Marc Grundl
Publikováno v:
Journal of Chemical Information and Modeling. 59:3565-3571
Thanks to their unique mode of action, covalent drugs represent an exceptional opportunity for drug design. After binding to a biologically relevant target system, covalent compounds form a reversible or irreversible covalent bond with a nucleophilic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101d39a767b2957ab2d1a2cdaed7d061
https://doi.org/10.1021/acs.jcim.9b00316
https://doi.org/10.1021/acs.jcim.9b00316
Autor:
Stefan Kochanek, Florian Stengel, Bin Huang, Qiang Guo, Jingdong Cheng, Marie Laura Niedermeier, Tatjana Engler, Wolfgang Baumeister, Rubén Fernández-Busnadiego, Alexander Pautsch, Melanie Maurer
Publikováno v:
Structure (London, England : 1993). 29(8)
The abnormal amplification of a CAG repeat in the gene coding for huntingtin (HTT) leads to Huntington's disease (HD). At the protein level, this translates into the expansion of a polyglutamine (polyQ) stretch located at the HTT N terminus, which re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ff3af0ae252c19124a36e82cb6064a
https://pubmed.ncbi.nlm.nih.gov/33909994
https://pubmed.ncbi.nlm.nih.gov/33909994
Autor:
Stefan Kochanek, Rubén Fernández-Busnadiego, Melanie Maurer, Wolfgang Baumeister, Florian Stengel, Marie Laura Niedermeier, Bin Huang, Jingdong Cheng, Qiang Guo, Tatjana Engler, Alexander Pautsch
SummaryThe abnormal amplification of a CAG repeat in the gene coding for huntingtin (HTT) leads to Huntington disease (HD). At the protein level, this translates into the expansion of a poly-glutamine (polyQ) stretch located at the HTT N-terminus, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::624dc6370541b815439487c9d0ca0a4e
https://doi.org/10.1101/2021.02.02.429316
https://doi.org/10.1101/2021.02.02.429316
Autor:
Markus R, Hermann, Alexander, Pautsch, Marc A, Grundl, Alexander, Weber, Christofer S, Tautermann
Publikováno v:
Journal of computer-aided molecular design. 35(4)
Drug discovery is an expensive and time-consuming process. To make this process more efficient quantum chemistry methods can be employed. The electrophilicity index is one property that can be calculated by quantum chemistry methods, and if calculate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ba92d119ca8fc62ec597792af3e24c77
https://pubmed.ncbi.nlm.nih.gov/33015740
https://pubmed.ncbi.nlm.nih.gov/33015740
Autor:
Ferruccio Palazzesi, Alexander Weber, Alexander Pautsch, Christofer S. Tautermann, Marc Grundl, Markus R. Hermann, Daniel Seeliger
Publikováno v:
Journal of chemical information and modeling. 60(6)
In the past decade, the pharmaceutical industry has paid closer attention to covalent drugs. Differently from standard noncovalent drugs, these compounds can exhibit peculiar properties, such as higher potency or longer duration of target inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d86b93e5c58747b4cf56c01a3fae08
https://pubmed.ncbi.nlm.nih.gov/32250627
https://pubmed.ncbi.nlm.nih.gov/32250627
Autor:
Tatjana Engler, Stefan Kochanek, Qiang Guo, Guenter Pfeifer, Bin Huang, Markus Otto, Patrick Oeckl, Wolfgang Baumeister, Jingdong Cheng, Manuel Seefelder, Alexander Pautsch, Rubén Fernández-Busnadiego, Franziska Moser, Melanie Maurer
Publikováno v:
Nature
The structure of huntingtin in complex with an interactor is determined to an overall resolution of 4 A, paving the way for improved understanding of the cellular functions of this protein. Huntingtin (HTT) is a large protein, essential for embryonic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed5227df6f10deaf223ecdee796e058
https://doi.org/10.1038/nature25502
https://doi.org/10.1038/nature25502