Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Alexander Pasternak"'
Autor:
Yun Wang, Kelvin Zhang, Peter Georgiev, Steven Wells, Haiyan Xu, Brian M Lacey, Zangwei Xu, Jason Laskey, Robbie Mcleod, Joey L Methot, Mark Bittinger, Alexander Pasternak, Sheila Ranganath
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243145 (2020)
Hematopoietic progenitor kinase 1 (HPK1), a hematopoietic cell-specific Ste20-related serine/threonine kinase, is a negative regulator of signal transduction in immune cells, including T cells, B cells, and dendritic cells (DCs). In mice, HPK1 defici
Externí odkaz:
https://doaj.org/article/122f7b4dd63e4038920f174d5a32c1d4
Autor:
Christina K. Psomas, Sarah Fidler, Malcolm Macartney, Richard Jeffreys, Lisa Reilly, Simon Collins, Santiago Moreno, Jean-Pierre Routy, Alexander Pasternak, Sabine Kinloch-de Loës
Publikováno v:
Journal of Virus Eradication, Vol 4, Iss 4, Pp 238-247 (2018)
Important data on the social, epidemiological and clinical aspects of HIV-1, comorbidities and hepatitis as well as data on novel antiretroviral agents and the cure agenda were presented at AIDS 2018. This report covers some of the highlights.
Externí odkaz:
https://doaj.org/article/7b1ead40dcaa4a1eb26380e5ed82d150
Publikováno v:
Journal of Virus Eradication, Vol 2, Iss , Pp 3- (2016)
Externí odkaz:
https://doaj.org/article/6ee337e4201944e3990e0775b3035335
Publikováno v:
Journal of Virus Eradication, Vol 2, Iss , Pp 12-13 (2016)
Externí odkaz:
https://doaj.org/article/1f5c61a2d24c4b1f99fe27c8b71a43c0
Autor:
Ellen Van Gulck, Lotte Bracke, Leo Heyndrickx, Sandra Coppens, Derek Atkinson, Céline Merlin, Alexander Pasternak, Eric Florence, Guido Vanham
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37792 (2012)
Upon interruption of antiretroviral therapy, HIV-infected patients usually show viral load rebound to pre-treatment levels. Four patients, hereafter referred to as secondary controllers (SC), were identified who initiated therapy during chronic infec
Externí odkaz:
https://doaj.org/article/11cb7ce5e6fe42df850165670045a485
Autor:
Mihirbaran Mandal, Li Xiao, Weidong Pan, Giovanna Scapin, Guoqing Li, Haiqun Tang, Shu-Wei Yang, Jianping Pan, Yuriko Root, Reynalda Keh de Jesus, Christine Yang, Winnie Prosise, Priya Dayananth, Asra Mirza, Alex G. Therien, Katherine Young, Amy Flattery, Charles Garlisi, Rumin Zhang, Donald Chu, Payal Sheth, Inhou Chu, Jin Wu, Carrie Markgraf, Hai-Young Kim, Ronald Painter, Todd W. Mayhood, Edward DiNunzio, Daniel F. Wyss, Alexei V. Buevich, Thierry Fischmann, Alexander Pasternak, Shuzhi Dong, Jacqueline D. Hicks, Artjohn Villafania, Lianzhu Liang, Nicholas Murgolo, Todd Black, William K. Hagmann, Jim Tata, Emma R. Parmee, Ann E. Weber, Jing Su, Haifeng Tang
Publikováno v:
Journal of Medicinal Chemistry. 65:16234-16251
With the emergence and rapid spreading of NDM-1 and existence of clinically relevant VIM-1 and IMP-1, discovery of pan inhibitors targeting metallo-beta-lactamases (MBLs) became critical in our battle against bacterial infection. Concurrent with our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72a226d0f459e4620537979c8da4d4d
https://doi.org/10.1021/acs.jmedchem.2c00766
https://doi.org/10.1021/acs.jmedchem.2c00766
Autor:
Katherine Young, Asra Mirza, Carl Balibar, Shuzhi Dong, Frank Bennett, Jinlong Jiang, Haiqun Tang, Claire Tudge, Jack Scott, Dexi Yang, Alexander Pasternak
Publikováno v:
Open Forum Infectious Diseases. 9
Background Metallo-beta (β)-lactamases (MBLs) are in the class B group of β-lactamases due to zinc ions in the active site that are required for enzymatic activity. MK-3866 is a small molecule MBL inhibitor (MBLi) that restores antibacterial activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e05d53410725c96796d9026a15a639b0
https://doi.org/10.1093/ofid/ofac492.1353
https://doi.org/10.1093/ofid/ofac492.1353
Autor:
Joey L. Methot, David A Candito, Sheila Ranganath, Zangwei Xu, Xavier Fradera, Abdelghani Achab, Erin F. DiMauro, Haiyan Xu, Samuel M. Levi, Brandon A. Vara, Brian M. Lacey, Mark Bittinger, Jennifer Piesvaux, Dustin M Smith, Alexander Pasternak, Jongwon Lim, David Jonathan Bennett, J. Richard Miller, Charles A. Lesburg, Shuhei Kawamura
Publikováno v:
ACS Med Chem Lett
[Image: see text] Hematopoietic progenitor kinase 1 (HPK1), a serine/threonine kinase, is a negative immune regulator of T cell receptor (TCR) and B cell signaling that is primarily expressed in hematopoietic cells. Accordingly, it has been reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3974d15fa6854f44fa7ca9ad4baa4e1b
https://doi.org/10.1021/acsmedchemlett.1c00096
https://doi.org/10.1021/acsmedchemlett.1c00096
Autor:
Dustin M Smith, Zangwei Xu, Joey L. Methot, Xavier Fradera, Alexander Pasternak, Elsie C Yu, Jennifer Piesvaux, Phieng Siliphaivanh, Brian M. Lacey, Mark Bittinger, Shuhei Kawamura, Charles A. Lesburg, J. Richard Miller, Ping Liu, Haiyan Xu
Publikováno v:
ACS Med Chem Lett
[Image: see text] Hematopoietic progenitor kinase (HPK1), a negative regulator of TCR-mediated T-cell activation, has been recognized as a novel antitumor immunotherapy target. Structural optimization of kinase inhibitor 4 through a systematic two-di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e303cf25b4e300aa5e1301e60ba336
https://doi.org/10.1021/acsmedchemlett.0c00672
https://doi.org/10.1021/acsmedchemlett.0c00672
Autor:
Derun Li, David L. Sloman, Abdelghani Achab, Hua Zhou, Meredeth A. McGowan, Catherine White, Craig Gibeau, Hongjun Zhang, Qinglin Pu, Indu Bharathan, Brett Hopkins, Kun Liu, Heidi Ferguson, Xavier Fradera, Charles A. Lesburg, Theodore A. Martinot, Ji Qi, Zhiguo J. Song, Jingjun Yin, Huangguang Zhang, Licheng Song, Baoqiang Wan, Suzanne DAddio, Nicolas Solban, J. Richard Miller, Beata Zamlynny, Alan Bass, Elizabeth Freeland, Bridget Ykoruk, Catherine Hilliard, Jude Ferraro, Jin Zhai, Ian Knemeyer, Karin M. Otte, Stella Vincent, Nunzio Sciammetta, Alexander Pasternak, David Jonathan Bennett, Yongxin Han
Publikováno v:
Journal of medicinal chemistry. 65(8)
3,3-Disubstituted oxetanes have been utilized as bioisosteres for gem-dimethyl and cyclobutane functionalities. We report the discovery of a novel class of oxetane indole-amine 2,3-dioxygenase (IDO1) inhibitors suitable for Q3W (once every 3 weeks) o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65de888aa90fb7088ca022d5b5ddf12
https://pubmed.ncbi.nlm.nih.gov/35239336
https://pubmed.ncbi.nlm.nih.gov/35239336