Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alexander P. Sakers"'
Autor:
Corey D Holman, Alexander P Sakers, Ryan P Calhoun, Lan Cheng, Ethan C Fein, Christopher Jacobs, Linus Tsai, Evan D Rosen, Patrick Seale
Publikováno v:
eLife, Vol 12 (2024)
The energy-burning capability of beige adipose tissue is a potential therapeutic tool for reducing obesity and metabolic disease, but this capacity is decreased by aging. Here, we evaluate the impact of aging on the profile and activity of adipocyte
Externí odkaz:
https://doaj.org/article/a87d04754b664275933a128e3f2ac78b
Autor:
Corey D. Holman, Alexander P. Sakers, Ryan P. Calhoun, Lan Cheng, Ethan C. Fein, Christopher Jacobs, Linus Tsai, Evan D. Rosen, Patrick Seale
Publikováno v:
bioRxiv
The energy-burning capability of beige adipose tissue is a potential therapeutic tool for reducing obesity and metabolic disease, but this capacity is decreased by aging. Here, we evaluate the impact of aging on the profile and activity of adipocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae03e6ad2b16c813d610caf93303005
https://europepmc.org/articles/PMC10055201/
https://europepmc.org/articles/PMC10055201/
Autor:
Katalin Susztak, Michelangella N. Arbocco, Chihiro Okada, Yu-Hua Tseng, Rojesh Shrestha, Matthew D. Lynes, Lan Cheng, Kirill Batmanov, Patrick Seale, Alexander P. Sakers, Corey D. Holman, Lucy Liaw, Farnaz Shamsi, Anthony R. Angueira
Publikováno v:
Nature Metabolism. 3:469-484
Brown adipose tissue can expend large amounts of energy, and therefore increasing its size or activity is a promising therapeutic approach to combat metabolic disease. In humans, major deposits of brown fat cells are found intimately associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::038754889ae0d83a0633f075cb6306a2
https://doi.org/10.1038/s42255-021-00380-0
https://doi.org/10.1038/s42255-021-00380-0
Autor:
Chihiro Okada, Katalin Susztak, Patrick Seale, Anthony R. Angueira, Alexander P. Sakers, Lan Cheng, Kirill Batmanov, Rojesh Shrestha
SummaryBrown adipose tissue can expend large amounts of energy and thus increasing its amount or activity is a promising therapeutic approach to combat metabolic disease. In humans, major deposits of brown fat cells are found intimately associated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e2c48ccf829054712be7db4931e9155
https://doi.org/10.1101/2020.06.23.164772
https://doi.org/10.1101/2020.06.23.164772
Publikováno v:
Plastic and Reconstructive Surgery Global Open
The World Health Organization (WHO) defines female genital mutilation (FGM) as any procedure that intentionally alters or causes injury to the female genitalia for nonmedical reasons.1 It is practiced primarily for sociocultural reasons with the grea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d81629464a66694e7b961241a174bd
https://pubmed.ncbi.nlm.nih.gov/32537325
https://pubmed.ncbi.nlm.nih.gov/32537325
Autor:
Chihiro Okada, Catherine Calvert, Patrick Seale, Michael Morley, Zhazira Irgebay, Ivona Percec, David Merrick, Alexander P. Sakers
Publikováno v:
Science. 364
A singular focus on fat Fatty tissue can expand in two ways: through increases in the size of individual adipocytes or through increases in the number of adipocytes. The former process promotes metabolic disease, and the latter protects against it. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b7db1ad17f5d3d4681af1c4c3b923b
https://doi.org/10.1126/science.aav2501
https://doi.org/10.1126/science.aav2501
Autor:
Hee-Woong Lim, Patrick Seale, Tara TeSlaa, Chan Wook Kwon, Megan Kissig, Lan Cheng, Rachel R. Stine, Alexander P. Sakers, Zachary E. Stine, Joshua D. Rabinowitz, Klaus H. Kaestner
Publikováno v:
Cell Stem Cell
Metabolic pathways dynamically regulate tissue development and maintenance. However, the mechanisms that govern the metabolic adaptation of stem or progenitor cells to their local niche are poorly understood. Here, we define the transcription factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362622b351bef4155283c8945290e2ef
https://pubmed.ncbi.nlm.nih.gov/31564549
https://pubmed.ncbi.nlm.nih.gov/31564549
Autor:
Hee-Woong Lim, Nathaniel W. Snyder, Kyoung-Jae Won, Mary T. Doan, Wenshan Wang, Joseph A. Baur, Sean O'Connor, Sophie Trefely, Alexis J. Cowan, Alexander P. Sakers, Rana K. Gupta, Paul Cohen, Richard L. Veech, Patrick Seale, Joshua D. Rabinowitz, M. Todd King, Mengle Shao, Jeff Ishibashi
Publikováno v:
Cell Metab
The precursor cells for metabolically beneficial beige adipocytes can alternatively become fibrogenic and contribute to adipose fibrosis. This adipogenic versus fibrogenic fate decision is poorly understood. Cold exposure or β3-adrenergic agonist tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36f955e0928d5b38c0c4b1499e2d2ce
https://pubmed.ncbi.nlm.nih.gov/31155495
https://pubmed.ncbi.nlm.nih.gov/31155495
Autor:
Jeff Ishibashi, Hee-Woong Lim, Suzanne N. Shapira, Patrick Seale, Kyoung-Jae Won, Alexander P. Sakers, Sona Rajakumari, Matthew J. Harms
The transcription factor early B-cell factor 2 (EBF2) is an essential mediator of brown adipocyte commitment and terminal differentiation. However, the mechanisms by which EBF2 regulates chromatin to activate brown fat-specific genes in adipocytes we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d626c08140ad0ad215181e4a7a575c82
https://europepmc.org/articles/PMC5411707/
https://europepmc.org/articles/PMC5411707/