Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Alexander P. S. Darlington"'
Publikováno v:
Microbial Biotechnology, Vol 17, Iss 11, Pp n/a-n/a (2024)
ABSTRACT Pseudomonas putida is widely used in industrial applications, including the recombinant proteins production, because of its natural advantageous properties. In this study, the gene encoding FleQ, the primary regulator of flagellar synthesis,
Externí odkaz:
https://doaj.org/article/90fafb10cfc348e8a40faa78991c7f1f
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Competition between synthetic genetic circuits and host genes for shared resources can complicate circuit design and lead to failure. Here the authors demonstrate, mathematically and experimentally, the use of orthogonal ribosomes to decouple competi
Externí odkaz:
https://doaj.org/article/47372b41d6ad4afa9243f6baf5c79a1b
Publikováno v:
2022 European Control Conference (ECC).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f006240d893f99826ae5d6337001918
https://doi.org/10.23919/ecc55457.2022.9837985
https://doi.org/10.23919/ecc55457.2022.9837985
Publikováno v:
Current Opinion in Biotechnology
Graphical abstract
Highlights • Limitations in molecular resources for gene expression influence bacterial physiology. • Bacteria optimise trade-offs between resource allocation and growth. • Resource allocation plays a role in the emergen
Highlights • Limitations in molecular resources for gene expression influence bacterial physiology. • Bacteria optimise trade-offs between resource allocation and growth. • Resource allocation plays a role in the emergen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c96f271789a0044608dcd11e1ce71a7
https://doi.org/10.1016/j.copbio.2019.08.004
https://doi.org/10.1016/j.copbio.2019.08.004
The gene expression capacity of bacterial cells depends on the interplay between growth and the availability of the transcriptional and translational machinery. Growth rate is widely accepted as the global physiological parameter controlling the allo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d9519ba4a327493c85609560d79bd81
https://doi.org/10.1101/2021.04.02.438188
https://doi.org/10.1101/2021.04.02.438188
Publikováno v:
Cell systems. 11(4)
Summary Recent work on engineering synthetic cellular circuitry has shown that non-regulatory interactions mediated by competition for gene expression resources can result in degraded performance or even failure. Transcriptional and translational res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2937e92ed604a713133fcba3382890f8
https://pubmed.ncbi.nlm.nih.gov/32937113
https://pubmed.ncbi.nlm.nih.gov/32937113
Recent work on engineering synthetic cellular circuitry has shown that non-regulatory interactions brought about through competition for shared gene expression resources, such as RNA polymerase and ribosomes, can result in degraded performance or eve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779c0faec3e9b7073aa88cdc5713e2d3
Publikováno v:
IFAC-PapersOnLine. 50:12653-12660
Microorganisms are widely used in synthetic biology for applications which require the simultaneous expression of multiple genes. However, gene expression in these microbes is limited by the number of free ribosomes. This resource limitation can resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8456420dc5799966d1a698f75a7ebf05
https://doi.org/10.1016/j.ifacol.2017.08.2239
https://doi.org/10.1016/j.ifacol.2017.08.2239
Publikováno v:
CDC
Recent work on engineering synthetic cellular circuitry has shown that non-regulatory interactions brought about through competition for shared gene expression resources, such as RNA polymerase and ribosomes, can result in degraded performance (circu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0828f6561b5e54bc96d66a2e5710645
https://doi.org/10.1109/cdc40024.2019.9028910
https://doi.org/10.1109/cdc40024.2019.9028910
Recent research in synthetic biology has highlighted the potential of translational resource allocation controllers to improve circuit modularity by dynamically allocating finite cellular resources in response to fluctuating circuit demands. The desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdad9cef52e3b99a1b86b9a9cde79864
https://eprints.whiterose.ac.uk/134950/1/paper-final-submitted.pdf
https://eprints.whiterose.ac.uk/134950/1/paper-final-submitted.pdf