Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Alexander P. Ducruet"'
Autor:
John S. Lazo, Alexander P. Ducruet, Rachel P. Sikorski, Peter Wipf, Thomas H. Graham, Andreas Vogt
Publikováno v:
Chemical Biology Drug Design. 67:66-73
Structure–activity analyses of synthetic disorazole C1 and eight of its analogs indicate that the presence of a vinyl oxirane moiety or a tetraene sequence is not necessary for potent cytotoxic and antimitotic properties. Using an automated multipa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a39962f14ab81eb9e90be5345cab00b1
https://doi.org/10.1111/j.1747-0285.2005.00313.x
https://doi.org/10.1111/j.1747-0285.2005.00313.x
Publikováno v:
Annual Review of Pharmacology and Toxicology. 45:725-750
▪ Abstract The complete sequencing of the human genome is generating many novel targets for drug discovery. Understanding the pathophysiological roles of these putative targets and assessing their suitability for therapeutic intervention has become
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9668209fe1d5c234cd8393596aaffd
https://doi.org/10.1146/annurev.pharmtox.45.120403.100040
https://doi.org/10.1146/annurev.pharmtox.45.120403.100040
Autor:
John S. Lazo, Alexander P. Ducruet
Publikováno v:
Journal of Biological Chemistry. 278:31838-31842
Cdc25A regulates cell cycle progression, has oncogenic and anti-apoptotic activity, and is over-expressed in many human tumors. Phosphorylation by Chk1 and Cds1/Chk2 down-regulates Cdc25A levels in response to genotoxic stresses. Nevertheless, it rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0fa8dff3fed7b800d059683138391b7
https://doi.org/10.1074/jbc.m303604200
https://doi.org/10.1074/jbc.m303604200
Autor:
Beomjun Joo, John S. Lazo, Eileen C. Southwick, and Andreas Vogt, Peter Wipf, Diana C. Aslan, Kathleen A Cooley, Alexander P. Ducruet
Publikováno v:
Journal of Medicinal Chemistry. 44:4042-4049
The Cdc25 dual specificity phosphatases have central roles in coordinating cellular signaling processes and cell proliferation, but potent and selective inhibitors are lacking. We experimentally examined the 1990 compound National Cancer Institute Di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc58979a9d862dab8ce13779773d8ff
https://doi.org/10.1021/jm0102046
https://doi.org/10.1021/jm0102046
Autor:
Andreas Vogt, Jon Chesebrough, John S. Lazo, Alexander P. Ducruet, Takahito Adachi, Kaoru Nemoto, Brian I. Carr
Publikováno v:
Journal of Biological Chemistry. 276:20544-20550
Protein phosphorylation frequently results in the subcellular redistribution of key signaling molecules, and this spatial change is critical for their activity. Here we have probed the effects of a Cdc25 inhibitor, 2-(2-mercaptoethanol)-3-methyl-1,4-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82bc70baaaa91afb1ff82be520da5580
https://doi.org/10.1074/jbc.m100078200
https://doi.org/10.1074/jbc.m100078200
Publikováno v:
Molecular Pharmacology. 64:199-201
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fea548fd0d33376ad23726d2fbcbb32
https://doi.org/10.1124/mol.64.2.199
https://doi.org/10.1124/mol.64.2.199
Autor:
Bethany Petrik, John S. Lazo, Billy W. Day, Raghavan Balachandran, Carolyn A. Kitchens, Brianne S. Raccor, Jane R. Stout, Peter Wipf, Fengfeng L. Xu, Marni Brisson Tierno, Thomas H. Graham, Celeste E. Reese, William S. Saunders, Claire E. Walczak, Alexander P. Ducruet
Disorazoles comprise a family of 29 macrocyclic polyketides isolated from the fermentation broth of the myxobacterium Sorangium cellulosum. The major fermentation product, disorazole A(1), was found previously to irreversibly bind to tubulin and to h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485e802de4275d3e915fdfd0842dfd6d
https://europepmc.org/articles/PMC2649750/
https://europepmc.org/articles/PMC2649750/
Autor:
Peter, Wipf, Thomas H, Graham, Andreas, Vogt, Rachel P, Sikorski, Alexander P, Ducruet, John S, Lazo
Publikováno v:
Chemical biologydrug design. 67(1)
Structure-activity analyses of synthetic disorazole C(1) and eight of its analogs indicate that the presence of a vinyl oxirane moiety or a tetraene sequence is not necessary for potent cytotoxic and antimitotic properties. Using an automated multipa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc94b61edb7fb5d088163453ed378138
https://pubmed.ncbi.nlm.nih.gov/16492150
https://pubmed.ncbi.nlm.nih.gov/16492150
Publikováno v:
Nature reviews. Drug discovery. 1(12)
Dual-specificity protein phosphatases are a subclass of protein tyrosine phosphatases that are uniquely able to hydrolyse the phosphate ester bond on both a tyrosine and a threonine or serine residue on the same protein. Dual-specificity phosphatases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83874444dd2074ac190033e551bd9ae9
https://pubmed.ncbi.nlm.nih.gov/12461518
https://pubmed.ncbi.nlm.nih.gov/12461518
Publikováno v:
Oncogene. 19(56)
One hallmark of neoplasia is the deregulation of cell cycle control mechanisms, which is secondary to altered protein phosphorylation. Dual specificity protein phosphatases uniquely dephosphorylate both phosphoserines/threonines and phosphotyrosines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc24b3e9f2bce75d073bced2dbe31206
https://pubmed.ncbi.nlm.nih.gov/11426646
https://pubmed.ncbi.nlm.nih.gov/11426646