Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Alexander P. Bye"'
Autor:
Joanne L. Mitchell, Dalia Khan, Rekha H. Rana, Neline Kriek, Amanda J. Unsworth, Tanya Sage, Alexander P. Bye, Michael Laffan, Susan Shapiro, Anjan Thakurta, Henri Grech, Karthik Ramasamy, Jonathan M. Gibbins
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
Multiple myeloma (MM) and its precursor states, smoldering myeloma (SM) and monoclonal gammopathy of undetermined significance (MGUS) are associated with increased incidence of thrombosis, however the cause of this is unknown. Lenalidomide treatment
Externí odkaz:
https://doaj.org/article/ed6b8d9969824f01bca243003c003438
Autor:
Alexander P. Bye, Neline Kriek, Tanya Sage, Suzannah J. Rawlings, Catherine Prodger, Murali Kesavan, Charlotte Lees, Stephen Booth, Louise G. Cowen, Kirsty Shefferd, Michael J. Desborough, Jonathan M. Gibbins, Toby A. Eyre
Publikováno v:
Haematologica, Vol 108, Iss 5 (2022)
Externí odkaz:
https://doaj.org/article/91084de43c7345ffaefe97d67355137d
Autor:
Renato S. Gaspar, Amanda J. Unsworth, Alaa Al-Dibouni, Alexander P. Bye, Tanya Sage, Michelle Stewart, Sara Wells, Roger D. Cox, Jonathan M. Gibbins, Dyan Sellayah, Craig E. Hughes
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Maternal over-nutrition increases the risk of diabetes and cardiovascular events in offspring. While prominent effects on cardiovascular health are observed, the impact on platelet physiology has not been studied. Here, we examined whether m
Externí odkaz:
https://doaj.org/article/83c5d0fd5e654fdebe78e6a31fc980f1
Autor:
Amanda J. Unsworth, Alexander P. Bye, Neline Kriek, Tanya Sage, Ashley A. Osborne, Dillon Donaghy, Jonathan M. Gibbins
Publikováno v:
Platelets, Vol 30, Iss 6, Pp 762-772 (2019)
The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone. Platelets express several members of the MAPK signalling casca
Externí odkaz:
https://doaj.org/article/bc64c667e4ca4e5497016e2359c4b0d5
Autor:
Amanda J. Unsworth, Alexander P. Bye, Tanya Sage, Renato S. Gaspar, Nathan Eaton, Caleb Drew, Alexander Stainer, Neline Kriek, Peter J. Volberding, James L. Hutchinson, Ryan Riley, Sarah Jones, Stuart J. Mundell, Weiguo Cui, Hervé Falet, Jonathan M. Gibbins
Publikováno v:
Haematologica, Vol 106, Iss 7 (2020)
Pim kinases are upregulated in several forms of cancer, contributing to cell survival and tumour development, but their role in platelet function and thrombotic disease has not been explored. We report for the first time that Pim-1 is expressed in hu
Externí odkaz:
https://doaj.org/article/05f03015be9b44e58b894ec840592a2f
Autor:
Alexander P. Bye, Amanda J. Unsworth, Michael J. Desborough, Catherine A.T. Hildyard, Niamh Appleby, David Bruce, Neline Kriek, Sophie H. Nock, Tanya Sage, Craig E. Hughes, Jonathan M. Gibbins
Publikováno v:
Blood Advances, Vol 1, Iss 26, Pp 2610-2623 (2017)
Abstract: The Bruton tyrosine kinase (Btk) inhibitor ibrutinib induces platelet dysfunction and causes increased risk of bleeding. Off-target inhibition of Tec is believed to contribute to platelet dysfunction and other side effects of ibrutinib. The
Externí odkaz:
https://doaj.org/article/debc716b148c4c92a81444c90dda03d7
Autor:
Kahdr A. Alatawi, Divyashree Ravishankar, Pabitra H. Patra, Alexander P. Bye, Alexander R. Stainer, Ketan Patel, Darius Widera, Sakthivel Vaiyapuri
Publikováno v:
Cells, Vol 10, Iss 10, p 2616 (2021)
1,8-cineole, a monoterpenoid is a major component of eucalyptus oil and has been proven to possess numerous beneficial effects in humans. Notably, 1,8-cineole is the primary active ingredient of a clinically approved drug, Soledum® which is being ma
Externí odkaz:
https://doaj.org/article/82d76c7a081249898cf98ac2961d52fd
Autor:
Alexander R. Stainer, Parvathy Sasikumar, Alexander P. Bye, Amanda J. Unsworth, Lisa M. Holbrook, Marcus Tindall, Julie A. Lovegrove, Jonathan M. Gibbins
Publikováno v:
TH Open, Vol 03, Iss 03, Pp e244-e258 (2019)
Quercetin, a dietary flavonoid, has been reported to possess antiplatelet activity. However, its extensive metabolism following ingestion has resulted in difficulty elucidating precise mechanisms of action. In this study, we aimed to characterize the
Externí odkaz:
https://doaj.org/article/01cb12021d2649e0b0fa8c7994e0003d
Autor:
Joanne L. Mitchell, Joanne L. Dunster, Neline Kriek, Amanda J. Unsworth, Tanya Sage, Yasmin M.M. Mohammed, Ilaria De Simone, Kirk A. Taylor, Alexander P. Bye, Geir Ólafsson, Mark Brunton, Sharon Mark, Leanne D. Dymott, Abigail Whyte, Neil Ruparelia, Charlie Mckenna, Jonathan M. Gibbins, Christopher I. Jones
Publikováno v:
Journal of Thrombosis and Haemostasis.
Autor:
Chiara E. Geyer, Hung-Jen Chen, Alexander P. Bye, Xue D. Manz, Denise Guerra, Tom G. Caniels, Tom PL Bijl, Guillermo R. Griffith, Willianne Hoepel, Steven W. de Taeye, Jennifer Veth, Alexander P. J. Vlaar, Amsterdam anon, Gestur Vidarsson, Harm Jan Bogaard, Jurjan Aman, Jonathan M. Gibbins, Marit J. van Gils, Menno de Winther, Jeroen den Dunnen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::460f9952ca5e13fbd45854e10150a19b
https://doi.org/10.2139/ssrn.4327343
https://doi.org/10.2139/ssrn.4327343