Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Alexander P Browning"'
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 1, p e1010844 (2023)
An enduring challenge in computational biology is to balance data quality and quantity with model complexity. Tools such as identifiability analysis and information criterion have been developed to harmonise this juxtaposition, yet cannot always reso
Externí odkaz:
https://doaj.org/article/3798ec48f08c426f9cf67366d0e7527b
Autor:
Alexander P Browning, Christopher Drovandi, Ian W Turner, Adrianne L Jenner, Matthew J Simpson
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 11, p e1010734 (2022)
Heterogeneity is a dominant factor in the behaviour of many biological processes. Despite this, it is common for mathematical and statistical analyses to ignore biological heterogeneity as a source of variability in experimental data. Therefore, meth
Externí odkaz:
https://doaj.org/article/3dbda7d33ea34bcba3a288d0150d50b0
Autor:
Alexander P Browning, Jesse A Sharp, Ryan J Murphy, Gency Gunasingh, Brodie Lawson, Kevin Burrage, Nikolas K Haass, Matthew Simpson
Publikováno v:
eLife, Vol 10 (2021)
Tumour spheroids are common in vitro experimental models of avascular tumour growth. Compared with traditional two-dimensional culture, tumour spheroids more closely mimic the avascular tumour microenvironment where spatial differences in nutrient av
Externí odkaz:
https://doaj.org/article/d7012f092c5e49fb9eff737de77d254c
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Tumour spheroid experiments with real-time fluorescent ubiquitination-based cell cycle imaging are interpreted using mathematical modelling and statistical identifiability analysis. A framework is provided to compare data obtained across different ex
Externí odkaz:
https://doaj.org/article/bdec315b109c4592a1ef94d2323d112d
Autor:
David J. Warne, Abhishek Varghese, Alexander P. Browning, Mario M. Krell, Christopher Drovandi, Wenbiao Hu, Antonietta Mira, Kerrie Mengersen, Adrianne L. Jenner
When effective vaccines are available, vaccination programs are typically one of the best defences against the spread of an infectious disease. Unfortunately, vaccination rates may be suboptimal for a prolonged duration as a result of slow uptake of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06dd3791be98faaa8c9723a29d4271ab
https://doi.org/10.1101/2022.12.13.22283297
https://doi.org/10.1101/2022.12.13.22283297
Publikováno v:
Journal of Visualized Experiments.
Tumor spheroids are fast becoming commonplace in basic cancer research and drug development. Obtaining data regarding protein expression within the spheroid at the cellular level is important for analysis, yet existing techniques are often expensive,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c87810857ec7d3fae2b04c4b72498cf
https://doi.org/10.3791/64103-v
https://doi.org/10.3791/64103-v
Autor:
Kevin Burrage, Tarunendu Mapder, Matthew J. Simpson, Jesse A Sharp, Alexander P Browning, Christopher M. Baker
Publikováno v:
Biophys J
Bacteria invest in a slow-growing subpopulation, called persisters, to ensure survival in the face of uncertainty. This hedging strategy is remarkably similar to financial hedging, where diversifying an investment portfolio protects against economic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1517875f9695199fdef1eea0a12421
https://doi.org/10.1016/j.bpj.2020.11.2260
https://doi.org/10.1016/j.bpj.2020.11.2260
Autor:
Alexander P. Browning, Niloufar Ansari, Christopher Drovandi, Angus P. R. Johnston, Matthew J. Simpson, Adrianne L. Jenner
Publikováno v:
Journal of The Royal Society Interface. 19
Biological heterogeneity is a primary contributor to the variation observed in experiments that probe dynamical processes, such as the internalization of material by cells. Given that internalization is a critical process by which many therapeutics a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20193b1b453c074f921e297fbc9f8172
https://doi.org/10.1098/rsif.2022.0019
https://doi.org/10.1098/rsif.2022.0019
Tumour spheroids are fast becoming commonplace in basic cancer research and drug development. Obtaining high-quality data relating to the inner structure of spheroids is important for analysis, yet existing techniques often use equipment that is not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d53358e7dcb9d7c110aaacbd1b60a84a