Zobrazeno 1 - 10
of 299
pro vyhledávání: '"Alexander P, Maxwell"'
Autor:
Marisa Cañadas-Garre, Blanca Baños-Jaime, Joaquín J. Maqueda, Laura J. Smyth, Ruaidhri Cappa, Ryan Skelly, Claire Hill, Eoin P. Brennan, Ross Doyle, Catherine Godson, Alexander P. Maxwell, Amy Jayne McKnight
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-20 (2024)
Abstract Background Chronic kidney disease (CKD) is a complex disorder that has become a high prevalence global health problem, with diabetes being its predominant pathophysiologic driver. Autosomal genetic variation only explains some of the predisp
Externí odkaz:
https://doaj.org/article/99d65bf485c945c2820dafe74e4345b0
Autor:
Michael Toal, Ruth Fergie, Michael Quinn, Christopher Hill, Ciaran O’Neill, Alexander P. Maxwell
Publikováno v:
Systematic Reviews, Vol 13, Iss 1, Pp 1-6 (2024)
Abstract Background IgA nephropathy (IgAN) is a common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD). Outcomes are highly variable and predicting risk of disease progression at an individual level is challenging. Accurate r
Externí odkaz:
https://doaj.org/article/702b16fc61234880b9ce40d80f83a3ed
Autor:
Marisa Cañadas-Garre, Joaquín J. Maqueda, Blanca Baños-Jaime, Claire Hill, Ryan Skelly, Ruaidhri Cappa, Eoin Brennan, Ross Doyle, Catherine Godson, Alexander P. Maxwell, Amy Jayne McKnight
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
IntroductionCardiovascular disease (CVD) is responsible for over 30% of mortality worldwide. CVD arises from the complex influence of molecular, clinical, social, and environmental factors. Despite the growing number of autosomal genetic variants con
Externí odkaz:
https://doaj.org/article/fd396bb37ab24ba998e03f620c3cd9f9
Autor:
Anna Rainey, Gareth J. McKay, Jane English, Ammarin Thakkinstian, Alexander Peter Maxwell, Michael Corr
Publikováno v:
BMC Nephrology, Vol 24, Iss 1, Pp 1-11 (2023)
Abstract Background Kidney transplantation is the optimal treatment option for most patients with end-stage kidney disease given the significantly lower morbidity and mortality rates compared to remaining on dialysis. Rejection and graft failure rema
Externí odkaz:
https://doaj.org/article/0b79d70bf0374cb58886d6f6f2efd951
Autor:
Wael Osman, Mira Mousa, Mohammed Albreiki, Zahrah Baalfaqih, Hinda Daggag, Claire Hill, Amy Jayne McKnight, Alexander P. Maxwell, Habiba Al Safar
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Diabetic kidney disease (DKD), also known as diabetic nephropathy, is the leading cause of renal impairment and end-stage renal disease. Patients with diabetes are at risk for DKD because of poor control of their blood glucose, as well as no
Externí odkaz:
https://doaj.org/article/2541b45db9974a509314d0c9a74625bb
Autor:
Laura J. Smyth, Emma H. Dahlström, Anna Syreeni, Katie Kerr, Jill Kilner, Ross Doyle, Eoin Brennan, Viji Nair, Damian Fermin, Robert G. Nelson, Helen C. Looker, Christopher Wooster, Darrell Andrews, Kerry Anderson, Gareth J. McKay, Joanne B. Cole, Rany M. Salem, Peter J. Conlon, Matthias Kretzler, Joel N. Hirschhorn, Denise Sadlier, Catherine Godson, Jose C. Florez, GENIE consortium, Carol Forsblom, Alexander P. Maxwell, Per-Henrik Groop, Niina Sandholm, Amy Jayne McKnight
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Approximately 40 percent of people with type 1 diabetes develop kidney disease, but the risk factors are not well understood. Here, the authors identify DNA methylation signatures associated with diabetic kidney disease, of which 21 biomarkers predic
Externí odkaz:
https://doaj.org/article/777a9666411244d6bce4bb7f84d0b5c3
Experiences of renal healthcare practitioners during the COVID-19 pandemic: a multi-methods approach
Autor:
Clare Mc Keaveney, Joanne Reid, Claire Carswell, Ann Bonner, Ilaria de Barbieri, William Johnston, Alexander P. Maxwell, Julien O’Riordan, Veronica Strini, Ian Walsh, Helen Noble
Publikováno v:
BMC Nephrology, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background Globally, renal healthcare practitioners provide intensive and protracted support to a highly complex multi-morbid patient population however knowledge about the impact of COVID-19 on these practitioners is extremely limited. Obje
Externí odkaz:
https://doaj.org/article/30d58469e78f4323b60d29149cfdc734
Autor:
Marisa Cañadas-Garre, Andrew T. Kunzmann, Kerry Anderson, Eoin P. Brennan, Ross Doyle, Christopher C. Patterson, Catherine Godson, Alexander P. Maxwell, Amy Jayne McKnight
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11209 (2023)
Increased albuminuria indicates underlying glomerular pathology and is associated with worse renal disease outcomes, especially in diabetic kidney disease. Many single nucleotide polymorphisms (SNPs), associated with albuminuria, could be potentially
Externí odkaz:
https://doaj.org/article/9c9d3867893349169657a96a25039a43
Autor:
Peter Bergin, Aoife Leggett, Chris R. Cardwell, Jayne V. Woodside, Ammarin Thakkinstian, Alexander P. Maxwell, Gareth J. McKay
Publikováno v:
BMC Nephrology, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background Haemodialysis (HD) patients tend to have higher levels of oxidative stress (OS), associated with increased morbidity and premature mortality, compared to the general population. Levels of malondialdehyde (MDA), a biomarker of OS,
Externí odkaz:
https://doaj.org/article/c59a2ae4d227454690a57f2fc85f713f
Autor:
Euan N. Paterson, Chris Cardwell, Thomas J. MacGillivray, Emanuele Trucco, Alexander S. Doney, Paul Foster, Alexander P. Maxwell, Gareth J. McKay, on behalf of The UK Biobank Eye and Vision Consortium
Publikováno v:
BMC Nephrology, Vol 22, Iss 1, Pp 1-11 (2021)
Abstract Background Associations between microvascular variation and chronic kidney disease (CKD) have been reported previously. Non-invasive retinal fundus imaging enables evaluation of the microvascular network and may offer insight to systemic ris
Externí odkaz:
https://doaj.org/article/d6ef67a4a916433dae9f480e6b269261