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of 3
pro vyhledávání: '"Alexander Otto Eberhardt"'
Reducing the metabolic burden of rRNA synthesis promotes healthy longevity in Caenorhabditis elegans
Autor:
Samim Sharifi, Prerana Chaudhari, Asya Martirosyan, Alexander Otto Eberhardt, Finja Witt, André Gollowitzer, Lisa Lange, Yvonne Woitzat, Eberechukwu Maryann Okoli, Huahui Li, Norman Rahnis, Joanna Kirkpatrick, Oliver Werz, Alessandro Ori, Andreas Koeberle, Holger Bierhoff, Maria Ermolaeva
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Ribosome biogenesis is initiated by RNA polymerase I (Pol I)-mediated synthesis of pre-ribosomal RNA (pre-rRNA). Pol I activity was previously linked to longevity, but the underlying mechanisms were not studied beyond effects on nucleolar st
Externí odkaz:
https://doaj.org/article/e8c06c7d253c4ce7a8ddf6f0c29bac62
Autor:
Gaurav Joshi, Alexander Otto Eberhardt, Lisa Lange, René Winkler, Steve Hoffmann, Christian Kosan, Holger Bierhoff
Publikováno v:
Cancers, Vol 12, Iss 10, p 3009 (2020)
A major transcriptional output of cells is ribosomal RNA (rRNA), synthesized by RNA polymerase I (Pol I) from multicopy rRNA genes (rDNA). Constitutive silencing of an rDNA fraction by promoter CpG methylation contributes to the stabilization of thes
Externí odkaz:
https://doaj.org/article/6d372df7c14f474f9eaefbac993fe16e
Autor:
Ingrid Grummt, Sergey Mareninov, Holger Bierhoff, Paul S. Mischel, Hiroko Shimada, Lionel M.L. Chow, Nazanin Majd, Makoto Suematsu, Greg Lucey, Alexander Otto Eberhardt, Maya Asano, Yuki Ban, Kaori Kofuji, Eric P. Smith, Eric C. Holland, Noriaki Minami, Ralph J. DeBerardinis, Daisuke Yamashita, Ichiro Nakano, Kazutaka Sumita, Yoshiki Ikeda, Hirofumi Yoshino, Yuki Sugiura, Robert Bachoo, Lisa Lange, Akshiv Malhotra, Mika Sasaki, Risa Kawaguchi, Yonehiro Kanemura, Akiyoshi Hirayama, Annmarie Ramkissoon, William H. Yong, Masaru Mori, Trisha Wise-Draper, Tomoyoshi Soga, Dimitrios Anastasiou, Jumpei Terakawa, Juri Kiyokawa, Tatsuya Ozawa, Hiroaki Wakimoto, Kara Wolfe, Atsuo T. Sasaki, Nobuyuki Onishi, Satoshi Kofuji, Satsuki Ikeda, Craig Horbinski, Takiko Daikoku, Koichi Okumura, Mikako Warren, Shin Morioka, Hideyuki Saya, Naoya Sakamoto, Shuji Kitahara, Oltea Sampetrean, Wataru Yasui, Tomoyuki Mashimo, Victoria L. Flanary
Publikováno v:
Nature cell biology
In many cancers, high proliferation rates correlate with elevation of rRNA and tRNA levels, and nucleolar hypertrophy. However, the underlying mechanisms linking increased nucleolar transcription and tumorigenesis are only minimally understood. Here