Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Alexander O Ward"'
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101097- (2022)
Summary: Quantitative assessment of post-ischemic cardiac remodeling is often hampered by tissue complexity and structural heterogeneity of the scar. Automated quantification of microscopy images offers an unbiased approach to reduce inter-observer v
Externí odkaz:
https://doaj.org/article/4e6845830efe4fb990f227464bb8a6e4
Autor:
M-Saadeh Suleiman, Paul C. Evans, Gianni D Angelini, Shameem Ladak, Alexander O Ward, Massimo Caputo, Graciela B. Sala-Newby, Mustafa Zakkar, Sarah J George
Publikováno v:
Ward, A, Sala-Newby, G, Ladak, S, Angelini, G, Caputo, M, Suleiman, M-S, Evans, P, George, S & Zakkar, M 2021, ' Nrf2-Keap-1 imbalance under acute shear stress induces inflammatory response in venous endothelial cells ', Perfusion . https://doi.org/10.1177/02676591211012571
Vascular endothelial cell stimulation is associated with the activation of different signalling pathways and transcription factors. Acute shear stress is known to induce different pro-inflammatory mediators such as IL-8. Nrf2 is activated by prolonge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd49f2dc89a0b1d27e7d4691c136541a
https://doi.org/10.1177/02676591211012571
https://doi.org/10.1177/02676591211012571
Autor:
Alexander O Ward, Gianni D Angelini, M.Saadeh Suleiman, Sarah J George, Jason L. Johnson, Mustafa Zakkar, Paul C. Evans, Robert Tulloh, Massimo Caputo
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Ward, A O, Angelini, G D, Caputo, M, Evans, P C, Johnson, J L, Suleiman, M S, Tulloh, R M, George, S J & Zakkar, M 2020, ' NF-κB inhibition prevents acute shear stress-induced inflammation in the saphenous vein graft endothelium ', Scientific Reports, vol. 10, 15133 (2020) . https://doi.org/10.1038/s41598-020-71781-6
Scientific Reports
Ward, A O, Angelini, G D, Caputo, M, Evans, P C, Johnson, J L, Suleiman, M S, Tulloh, R M, George, S J & Zakkar, M 2020, ' NF-κB inhibition prevents acute shear stress-induced inflammation in the saphenous vein graft endothelium ', Scientific Reports, vol. 10, 15133 (2020) . https://doi.org/10.1038/s41598-020-71781-6
Scientific Reports
The long saphenous vein (LSV) is commonly used as a conduit in coronary artery bypass grafting. However, long term patency remains limited by the development of vascular inflammation, intimal hyperplasia and accelerated atherosclerosis. The impact of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f378c717aa319b9f793492951c756fb9
http://link.springer.com/article/10.1038/s41598-020-71781-6
http://link.springer.com/article/10.1038/s41598-020-71781-6
Autor:
Ella M M A Martin, Sally L. Dunwoodie, Ralph Patrick, Junjie Du, Richard P. Harvey, Dhanushi Abeygunawardena, Osvaldo Contreras, Vaibhao Janbandhu, Ernestene Yao, Nenad Bursac, Yanzhen Li, Alexander O. Ward, David T. Humphreys, Nona Farbehi, Vikram Tallapragada
Publikováno v:
Cell Stem Cell
We report that cardiac fibroblasts (CFs) and mesenchymal progenitors are more hypoxic than other cardiac interstitial populations, express more hypoxia-inducible factor 1α (HIF-1α), and exhibit increased glycolytic metabolism. CF-specific deletion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc1f1934114281595000494b9421dea
https://pubmed.ncbi.nlm.nih.gov/34762860
https://pubmed.ncbi.nlm.nih.gov/34762860
Publikováno v:
London Review of Education (2020)
In light of the UK government’s decision to make first aid education mandatory in schools, this article adds to the body of evidence to inform the implementation of this decision. Our research aimed to explore whether providing extra support to tea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6abb755d710f52edd4b7fb180475b8b0
https://ucl.scienceopen.com/hosted-document?doi=10.14324/LRE.18.2.07
https://ucl.scienceopen.com/hosted-document?doi=10.14324/LRE.18.2.07
Saphenous vein graft disease, pathophysiology, prevention, and treatment. A review of the literature
Autor:
Gianni D Angelini, Gustavo Guida, Alexander O Ward, Vito Domenico Bruno, Mustafa Zakkar, Sarah J George, Massimo Caputo
Publikováno v:
Guida, G, Ward, A O, Bruno, V D, George, S J, Caputo, M, Angelini, G D & Zakkar, M 2020, ' Saphenous vein graft disease, pathophysiology, prevention, and treatment. A review of the literature ', Journal of Cardiac Surgery . https://doi.org/10.1111/jocs.14542
BACKGROUND: The saphenous vein remains the most frequently used conduit for coronary artery bypass grafting, despite reported unsatisfactory long-term patency rates. Understanding the pathophysiology of vein graft failure and attempting to improve it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c841c70f860bd8f7bdbd868de26c5a1
https://research-information.bris.ac.uk/ws/files/240115056/jocs.14542_1_.pdf
https://research-information.bris.ac.uk/ws/files/240115056/jocs.14542_1_.pdf
Publikováno v:
Ward, A O, Caputo, M, Angelini, G D, George, S J & Zakkar, M 2017, ' Activation and inflammation of the venous endothelium in vein graft disease ', Atherosclerosis . https://doi.org/10.1016/j.atherosclerosis.2017.08.023
The long saphenous vein is the most commonly used conduit in coronary artery bypass graft (CABG) surgery when bypassing multiple diseased arteries; however, its use is complicated by the development of vascular inflammation, intimal hyperplasia and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c9a4fa07fdf87a17ca6073cedc4c12
https://doi.org/10.1016/j.atherosclerosis.2017.08.023
https://doi.org/10.1016/j.atherosclerosis.2017.08.023
Autor:
A. Jennifer Morton, Stephen J. Sawiak, Simon Puttick, Nigel I. Wood, Alexander O. Ward, T. Adrian Carpenter, Guido Buonincontri
Publikováno v:
Journal of Huntington's Disease. 3:25-32
Background: Increasingly, evidence from studies in both animal models and patients suggests that cardiovascular dysfunction is important in HD. Previous studies measuring function of the left ventricle (LV) in the R6/2 mouse model have found a clear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e74584739cde02060f72ade473375179
https://doi.org/10.3233/jhd-130083
https://doi.org/10.3233/jhd-130083
Autor:
Vito Domenico Bruno, Gustavo Guida, Sarah J George, Mustafa Zakkar, Gianni, R. Krishnadas, Alexander O Ward, D Angelini
Publikováno v:
Cardiovascular Research. 114:S4-S4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64f6ea4637e173414edcd9fe3d7b5225
https://doi.org/10.1093/cvr/cvy216.016
https://doi.org/10.1093/cvr/cvy216.016
Autor:
Annalisa Bucchi, Andrew W. Trafford, Leonardo Sacconi, Hugh D. Piggins, Lucia De Franceschi, Francesco S. Pavone, Nikolai Rex, Elisabetta Cerbai, Raffaele Coppini, Silvia Hayer, Garth J. S. Cooper, Paul Begley, Leslie M. Loew, Anne Berit Johnsen, Corrado Poggesi, Alessandra Ghigo, Yanwen Wang, Godfrey L. Smith, Paula A. da Costa Martins, Mark R. Boyett, Gianni D Angelini, James Cimino, Cecilia Ferrantini, Tetyana Shvets, Lorenzo Silengo, Milat Inci, Halina Dobrzynski, Lars S. Maier, Stefan Wagner, Marina Scardigli, Claudia Crocini, Attila Kiss, Amy Watkins, Can-Martin Sag, Fiorella Altruda, Francesca Vinchi, Emanuela Tolosano, Mustafa Zakkar, Bruno K. Podesser, Ping Yan, Dario DiFrancesco, Stephanie J. Church, Birgit Niederreiter, Sara Petrillo, Servé Olieslagers, Emilio Hirsch, Kurt Redlich, Alexander O Ward, Alicia D'Souza, David A. Eisner, Sarah J George
Publikováno v:
Cardiovascular Research. 111:S90-S91
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43f0da0bd4201ed531258cc0036a99c2
https://doi.org/10.1093/cvr/cvw142
https://doi.org/10.1093/cvr/cvw142