Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Alexander O Pasternak"'
Autor:
Alexander O Pasternak, Jelmer Vroom, Neeltje A Kootstra, Ferdinand WNM Wit, Marijn de Bruin, Davide De Francesco, Margreet Bakker, Caroline A Sabin, Alan Winston, Jan M Prins, Peter Reiss, Ben Berkhout, The Co-morBidity in Relation to Aids (COBRA) Collaboration
Publikováno v:
eLife, Vol 10 (2021)
Background: It remains unclear whether combination antiretroviral therapy (ART) regimens differ in their ability to fully suppress human immunodeficiency virus (HIV) replication. Here, we report the results of two cross-sectional studies that compare
Externí odkaz:
https://doaj.org/article/7a0e3e84da5a40f19a902a05307fda50
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140791 (2015)
High levels of adherence to antiretroviral therapy (ART) are necessary for achieving and maintaining optimal virological suppression, as suboptimal adherence leads to therapy failure and disease progression. It is well known that adherence to ART pre
Externí odkaz:
https://doaj.org/article/8e464ee622cc4e5bbe5335d3c2ecf5c9
Autor:
Maja Kiselinova, Alexander O Pasternak, Ward De Spiegelaere, Dirk Vogelaers, Ben Berkhout, Linos Vandekerckhove
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85999 (2014)
Cell-associated (CA) HIV-1 RNA is considered a potential marker for assessment of viral reservoir dynamics and antiretroviral therapy (ART) response in HIV-infected patients. Recent studies employed sensitive seminested real-time quantitative (q)PCR
Externí odkaz:
https://doaj.org/article/4c110e7a40a149f8ad5564fadec1d816
Autor:
Alexander O Pasternak, Suzanne Jurriaans, Margreet Bakker, Jan M Prins, Ben Berkhout, Vladimir V Lukashov
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8490 (2009)
BACKGROUND:Combination antiretroviral therapy (cART), the standard of care for HIV-1 infection, is considered to be successful when plasma viremia remains below the detection limit of commercial assays. Yet, cART fails in a substantial proportion of
Externí odkaz:
https://doaj.org/article/f187cc942f1345f898e0e072746978c8
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/f2a4ed06a56d45e1a098877c3744d54d
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/d69cf669970e4fc08ade52c715fb12df
Autor:
Roxane Verdikt, Maryam Bendoumou, Sophie Bouchat, Lorena Nestola, Alexander O. Pasternak, Gilles Darcis, Véronique Avettand-Fenoel, Caroline Vanhulle, Amina Aït-Ammar, Marion Santangelo, Estelle Plant, Valentin Le Douce, Nadège Delacourt, Aurelija Cicilionytė, Coca Necsoi, Francis Corazza, Caroline Pereira Bittencourt Passaes, Christian Schwartz, Martin Bizet, François Fuks, Asier Sáez-Cirión, Christine Rouzioux, Stéphane De Wit, Ben Berkhout, Virginie Gautier, Olivier Rohr, Carine Van Lint
Publikováno v:
EBioMedicine, Vol 79, Iss , Pp 103985- (2022)
Summary: Background: The multiplicity, heterogeneity, and dynamic nature of human immunodeficiency virus type-1 (HIV-1) latency mechanisms are reflected in the current lack of functional cure for HIV-1. Accordingly, all classes of latency-reversing a
Externí odkaz:
https://doaj.org/article/b64342c7f9c945c392341ed58313d142
Autor:
Marilia R. Pinzone, Sam Weissman, Alexander O. Pasternak, Ryan Zurakowski, Stephen Migueles, Una O’Doherty
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
Historically, naive cells have been considered inconsequential to HIV persistence. Here, we compared the contributions of naive and memory cells to the reservoirs of individuals with a spectrum of reservoir sizes and variable immunological control. W
Externí odkaz:
https://doaj.org/article/07e18e798f2e4473be66cf7c80da6216
Autor:
Marilia Rita Pinzone, D. Jake VanBelzen, Sam Weissman, Maria Paola Bertuccio, LaMont Cannon, Emmanuele Venanzi-Rullo, Stephen Migueles, R. Brad Jones, Talia Mota, Sarah B. Joseph, Kevin Groen, Alexander O. Pasternak, Wei-Ting Hwang, Brad Sherman, Anastasios Vourekas, Giuseppe Nunnari, Una O’Doherty
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
How HIV reservoirs are shaped over time on antiviral therapy is poorly understood. Here, the authors analyze the dynamics of the HIV reservoir by longitudinal proviral sequencing revealing that HIV reservoir expression can contribute to its clearance
Externí odkaz:
https://doaj.org/article/bcf0eb263eba47799a2cae2421234886
Autor:
Mirte Scherpenisse, Neeltje A. Kootstra, Margreet Bakker, Ben Berkhout, Alexander O. Pasternak
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
Human immunodeficiency virus (HIV) infection is currently managed by antiretroviral drugs, which block virus replication and promote immune restoration. However, the latter effect is not universal, with a proportion of infected individuals failing to
Externí odkaz:
https://doaj.org/article/32dcdb13ffcc495e9446aa3ff1e69aa0