Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Alexander Nolze"'
Publikováno v:
Cells, Vol 12, Iss 18, p 2269 (2023)
Calcineurin, a serine/threonine phosphatase regulating transcription factors like NFaT and CREB, is well known for its immune modulatory effects and role in cardiac hypertrophy. Results from experiments with calcineurin knockout animals and calcineur
Externí odkaz:
https://doaj.org/article/2429f4efd9414259847752b76bb78f53
Autor:
Barbara Schreier, Christian Stern, Virginie Dubourg, Alexander Nolze, Sindy Rabe, Sigrid Mildenberger, Claudia Wickenhauser, Michael Gekle
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Vascular EGF receptors (EGFR) influence function and structure of arterial vessels. In genetic mouse models we described the role of vascular smooth muscle (VSMC) EGFR for proper physiological function and structure as well as for pathophysi
Externí odkaz:
https://doaj.org/article/239465dc77464e889819e565945224a9
Autor:
Mandy Rauschner, Luisa Lange, Thea Hüsing, Sarah Reime, Alexander Nolze, Marcel Maschek, Oliver Thews, Anne Riemann
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-14 (2021)
Abstract Background The low extracellular pH (pHe) of tumors resulting from glycolytic metabolism is a stress factor for the cells independent from concomitant hypoxia. The aim of the study was to analyze the impact of acidic pHe on gene expression o
Externí odkaz:
https://doaj.org/article/3e829c4494cc4738943f649920ff207c
Autor:
Marie-Christin Schulz, Virginie Dubourg, Alexander Nolze, Michael Kopf, Gerald Schwerdt, Michael Gekle
Publikováno v:
Antioxidants, Vol 12, Iss 2, p 412 (2023)
Crosstalk of renal epithelial cells with interstitial fibroblasts plays an important role in kidney pathophysiology. A previous study showed that crosstalk between renal epithelial cells and renal fibroblasts protects against acidosis-induced damage.
Externí odkaz:
https://doaj.org/article/4404032215334d618415a9bd78a7e602
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
During aging, the cardiovascular system is especially prone to a decline in function and to life-expectancy limiting diseases. Cardiovascular aging is associated with increased arterial stiffness and vasoconstriction as well as left ventricular hyper
Externí odkaz:
https://doaj.org/article/005d710b93674fcb959b04301faebe3d
Publikováno v:
Cells, Vol 9, Iss 1, p 143 (2020)
Environmental food contaminants constitute a threat to human health. For instance, the globally spread mycotoxin Ochratoxin A (OTA) contributes to chronic kidney damage by affecting proximal tubule cells via unknown mechanisms. We applied a top-down
Externí odkaz:
https://doaj.org/article/4991c4cf9558471887dc33b64ed6d3d0
Autor:
Sigrid Mildenberger, Barbara Schreier, Alexander Nolze, Michael Gekle, Sindy Rabe, Christian Stern
Publikováno v:
Diabetologia
Aims/hypothesis Obesity causes type 2 diabetes leading to vascular dysfunction and finally renal end-organ damage. Vascular smooth muscle (VSM) EGF receptor (EGFR) modulates vascular wall homeostasis in part via serum response factor (SRF), a major r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce0da8cc0209710723cbc450e03a3bc
https://doi.org/10.1007/s00125-020-05187-4
https://doi.org/10.1007/s00125-020-05187-4
Publikováno v:
British journal of pharmacologyREFERENCES. 179(13)
During the past decades, the mineralocorticoid receptor (MR) has evolved from a much-overlooked member of the steroid hormone receptor family to an important player, not only in volume and electrolyte homeostasis but also in pathological changes occu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1addd82e93e6f6d0cccfa3e0ec94e71a
https://pubmed.ncbi.nlm.nih.gov/34811739
https://pubmed.ncbi.nlm.nih.gov/34811739
Autor:
Katja Quarch, Stefanie Ruhs, Claudia Grossmann, Michael Gekle, Conny Köhler, Alexander Nolze, Nicole Strätz
Publikováno v:
Acta physiologica (Oxford, England)REFERENCES. 233(3)
Aim This study investigates the role of calcineurin for angiotensin II (AngII)-induced vascular remodelling with the help of a mouse model lacking the catalytic beta subunit of calcineurin (PPP3CB KO). Methods Wildtype (WT) and PPP3CB KO mice were tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6a81285e0eaa4527757e13a1821c43
https://pubmed.ncbi.nlm.nih.gov/34228904
https://pubmed.ncbi.nlm.nih.gov/34228904
Autor:
Paolo Fornara, Barbara Seliger, Marcel Köhn, Isabell Hennemeier, Sandro Dittmar, Patrick Azinovic, Hans-Ulrich Humpf, Mirjana Polovic, Alexander Nolze, Gerald Schwerdt, Michael Gekle, Gerit Theil
Publikováno v:
Cellular and Molecular Life Sciences. 75:2241-2256
Long non-coding RNAs represent a fraction of the transcriptome that is being increasingly recognized. For most of them no function has been allocated so far. Here, we describe the nature and function of a novel non-protein-coding transcript, named WI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b926044c0e74c6166fcaa38893cb3bf0
https://doi.org/10.1007/s00018-017-2731-6
https://doi.org/10.1007/s00018-017-2731-6