Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Alexander Nikolayev"'
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114019 (2014)
Nicotinamide phosphoribosyltransferase (NAMPT) plays an important role in cellular bioenergetics. It is responsible for converting nicotinamide to nicotinamide adenine dinucleotide, an essential molecule in cellular metabolism. NAMPT has been extensi
Externí odkaz:
https://doaj.org/article/037495b7925d4c40ae1c674c6d37821e
Autor:
Ruslan D. Novosiadly, Michael Kalos, Gerald E. Hall, David Surguladze, Gregory P. Donoho, Thompson N. Doman, Jason R. Manro, Frank C. Dorsey, Krishna Chodavarapu, Manisha Brahmachary, Bo Tan, Alexander Nikolayev, Kenneth D. Roth, Carmine Carpenito, Shuang Luo, Xiaodong Huang, Bonita D. Jones, Catalina M. Meyer, Yanxia Li, Andrew Capen, Darin Chin, Andreas Sonyi, Erik R. Rasmussen, Zhao Hai Lu, Nelusha Amaladas, Sandaruwan Geeganage, David A. Schaer
Supplementary Figure Legends & Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057a178b991babc2517ecf5b994d7838
https://doi.org/10.1158/1078-0432.22471418.v1
https://doi.org/10.1158/1078-0432.22471418.v1
Autor:
Ruslan D. Novosiadly, Michael Kalos, Gerald E. Hall, David Surguladze, Gregory P. Donoho, Thompson N. Doman, Jason R. Manro, Frank C. Dorsey, Krishna Chodavarapu, Manisha Brahmachary, Bo Tan, Alexander Nikolayev, Kenneth D. Roth, Carmine Carpenito, Shuang Luo, Xiaodong Huang, Bonita D. Jones, Catalina M. Meyer, Yanxia Li, Andrew Capen, Darin Chin, Andreas Sonyi, Erik R. Rasmussen, Zhao Hai Lu, Nelusha Amaladas, Sandaruwan Geeganage, David A. Schaer
Figure S1. Efficacy of pemetrexed in Lewis Lung carcinoma model and metabolomic analysis of MC38 tumor bearing mice treated with 50 mg/kg of pemetrexed Figure S2. T cell inflamed phenotype induced by pemetrexed is modestly reduced in tumors upon comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dcf5c80af2bf8dacf087ab7a6132752
https://doi.org/10.1158/1078-0432.22471421
https://doi.org/10.1158/1078-0432.22471421
Autor:
Ruslan D. Novosiadly, Michael Kalos, Gerald E. Hall, David Surguladze, Gregory P. Donoho, Thompson N. Doman, Jason R. Manro, Frank C. Dorsey, Krishna Chodavarapu, Manisha Brahmachary, Bo Tan, Alexander Nikolayev, Kenneth D. Roth, Carmine Carpenito, Shuang Luo, Xiaodong Huang, Bonita D. Jones, Catalina M. Meyer, Yanxia Li, Andrew Capen, Darin Chin, Andreas Sonyi, Erik R. Rasmussen, Zhao Hai Lu, Nelusha Amaladas, Sandaruwan Geeganage, David A. Schaer
Purpose:Combination strategies leveraging chemotherapeutic agents and immunotherapy have held the promise as a method to improve benefit for patients with cancer. However, most chemotherapies have detrimental effects on immune homeostasis and differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55d83fcda2c247c186c9439427cc003
https://doi.org/10.1158/1078-0432.c.6527882.v1
https://doi.org/10.1158/1078-0432.c.6527882.v1
Autor:
Wesley H. Anderson, Paul L. Ornstein, Vladamir Tolstikov, Guy Carter, Renhua Li, Brian J. Eastwood, Carl D Overshiner, Alexander Nikolayev, Kurt Rasmussen, Stephen Smith, Gary Gilmour, Stephen Swanson, Linda M. Rorick-Kehn, Xia Li, Keith A. Wafford, John T. Catlow, Jeffrey M. Witkin, Stephen N. Mitchell, Charles H. Mitch, Ming-Shang Kuo, Jennifer Li, James A. Monn
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 361:68-86
The ability of the N-methyl-d-aspartate receptor antagonist ketamine to alleviate symptoms in patients suffering from treatment-resistant depression (TRD) is well documented. In this paper, we directly compare in vivo biologic responses in rodents el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c85af1aba740a496f470de81cbfe95b
https://doi.org/10.1124/jpet.116.238121
https://doi.org/10.1124/jpet.116.238121
Autor:
Yanxia Li, Frank C. Dorsey, Jason Manro, Kenneth D. Roth, Erik R. Rasmussen, Ruslan D. Novosiadly, Gerald Hall, Andrew Capen, Bonita D. Jones, Zhao Hai Lu, Bo Tan, Gregory P. Donoho, Darin Chin, Manisha Brahmachary, David Schaer, Thompson N. Doman, Sandaruwan Geeganage, Catalina Meyer, Nelusha Amaladas, Andreas Sonyi, Michael Kalos, Carmine Carpenito, Krishna Chodavarapu, Shuang Luo, Xiaodong Huang, David Surguladze, Alexander Nikolayev
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 25(23)
Purpose: Combination strategies leveraging chemotherapeutic agents and immunotherapy have held the promise as a method to improve benefit for patients with cancer. However, most chemotherapies have detrimental effects on immune homeostasis and differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d28af80d9d6edb3d4c795aee1aeedc
https://pubmed.ncbi.nlm.nih.gov/31562205
https://pubmed.ncbi.nlm.nih.gov/31562205
Autor:
Graham N. Wishart, Richard E. Higgs, Christian C. Felder, Jeffrey M. Witkin, Vladimir Tolstikov, Ming-Shang Kuo, Wesley H. Anderson, Beverly A. Heinz, John T. Catlow, Alexander Nikolayev, Xia Li, Douglas A. Schober, Carl D Overshiner
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 351:448-456
Scopolamine produces rapid and significant symptom improvement in patients with depression, and most notably in patients who do not respond to current antidepressant treatments. Scopolamine is a nonselective muscarinic acetylcholine receptor antagoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12828a04885b8647fb9bb921e3096fc0
https://doi.org/10.1124/jpet.114.216804
https://doi.org/10.1124/jpet.114.216804
Autor:
Frank C. Dorsey, Thompson N. Doman, Kenneth D. Roth, Yanxia Li, Ruslan D. Novosiadly, Gerald Hall, Greg Donoho, Carmine Carpenito, Jason Manro, David Schaer, Erik R. Rasmussen, David Surguladze, Xiaodong Hong, Bonita D. Jones, Bo Tan, Alexander Nikolayev, Krishna Chodavarapu, Zhao Hai Lu, Shuang Luo, Manisha Brahmachary, Andrew Capen, Andreas Sonyi, Michael Kalos, Nelusha Amaladas, Darin Chin, Sandaruwan Geeganage, Catalina Meyer
Publikováno v:
Cancer Research. 79:3945-3945
Combination strategies leveraging chemotherapy and immunotherapy have held the promise as a method to improve benefit to cancer patients. However, most chemotherapies have detrimental effects on immune homeostasis and do not induce immunogenic cell d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bbe0a693be054d24e0d0e7de2340a9e
https://doi.org/10.1158/1538-7445.am2019-3945
https://doi.org/10.1158/1538-7445.am2019-3945
Autor:
Alexander Nikolayev, Ana Cerezo, Susana Velasco-Miguel, Juan M. Funes, Karim A. Benhadji, Sandaruwan Geeganage, Gloria Martinez-del Hoyo, Frank C. Dorsey, Raymond Gilmour, Henry James Robert, Kenneth D. Roth, Sandra Peregrina, Lillian Sams, Ramón Campos-Olivas, Laura Diezma
Publikováno v:
Cancer Research. 79:2187-2187
Tryptophan metabolism plays a central role in immunosuppression through the local depletion of tryptophan with the concomitant production and accumulation of kynurenine, both of which are immunosuppressive. Indoleamine 2,3-dioxygenase 1 (IDO1), a hem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e0cd7d0ee555ecbb2c64150cc54e3c2
https://doi.org/10.1158/1538-7445.am2019-2187
https://doi.org/10.1158/1538-7445.am2019-2187
Autor:
Wesley H. Anderson, Christian C. Felder, Ming-Shang Kuo, John T. Catlow, Jeffrey M. Witkin, Vladimir Tolstikov, Douglas A. Schober, Xia Li, Anna E Martin, Anastasia Laksmanan, Alexander Nikolayev, Richard E. Higgs
Publikováno v:
CNSneurological disorders drug targets. 16(4)
Background Conventional antidepressants lack efficacy for many patients (treatmentresistant depression or TRD) and generally take weeks to produce full therapeutic response in others. Emerging data has identified certain drugs such as ketamine as rap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68afc27987793faf3a3575f6a31a1da
https://pubmed.ncbi.nlm.nih.gov/28294051
https://pubmed.ncbi.nlm.nih.gov/28294051