Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Alexander N. Kapustin"'
Autor:
Alexander N. Kapustin, Paul Davey, David Longmire, Carl Matthews, Emily Linnane, Nitin Rustogi, Maria Stavrou, Paul W. A. Devine, Nicholas J. Bond, Lyndsey Hanson, Silvia Sonzini, Alexey Revenko, A. Robert MacLeod, Sarah Ross, Elisabetta Chiarparin, Sanyogitta Puri
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Kapustin et al. investigate the intracellular trafficking of anti-KRAS antisense oligonucleotides. They show that the oligonucleotide AZD4785 is recycled via late endosomes in extracellular vesicles in both cells with poor and good oligo productive u
Externí odkaz:
https://doaj.org/article/e4d7d13e7cd04080b03cedf4614a86e6
Autor:
Alexander N. Kapustin, Natalia Kalinina, Tatiana Lopatina, Sean M. Davidson, Nunzio Iraci, Svetlana Tamkovich, Lesley Smyth, Dmitry Ter-Ovanesyan, Evgeniy G. Evtushenko, Olga Savelieva, Sergio Bertazzo, Vassiliy Aushev, Rebecca Dragovic, Tannia Gracia, Margarete Heck, Yelena V. Parfyonova, Catherine M. Shanahan, Vsevolod Tkachuk
Publikováno v:
Journal of Extracellular Vesicles, Vol 4, Iss 0, Pp 1-3 (2015)
Externí odkaz:
https://doaj.org/article/0c28ba458fed4094895c11e888564867
Autor:
Sadia Ahmad, Catherine M. Shanahan, Meredith Whitehead, Rick H. van Gorp, Alexander N. Kapustin, Jayanta Bordoloi, Leon J. Schurgers, Malgorzata Furmanik
Publikováno v:
Arteriosclerosis Thrombosis and Vascular Biology, 41(2), 898-914. LIPPINCOTT WILLIAMS & WILKINS
Arteriosclerosis, Thrombosis, and Vascular Biology
Arteriosclerosis, Thrombosis, and Vascular Biology
Supplemental Digital Content is available in the text.
Objective: Vascular calcification is common among aging populations and mediated by vascular smooth muscle cells (VSMCs). The endoplasmic reticulum (ER) is involved in protein folding and ER
Objective: Vascular calcification is common among aging populations and mediated by vascular smooth muscle cells (VSMCs). The endoplasmic reticulum (ER) is involved in protein folding and ER
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed9d18ff4c1e39d6c3f45b31fc08f507
https://cris.maastrichtuniversity.nl/en/publications/9a49fde3-fac5-4516-af6f-f89b05678874
https://cris.maastrichtuniversity.nl/en/publications/9a49fde3-fac5-4516-af6f-f89b05678874
Autor:
Celio X.C. Santos, Matt C. Danzi, Francesco De Virgiliis, Thomas H. Hutson, Arnau Hervera, Elena Tantardini, José Antonio del Río, Mike Fainzilber, Roland A. Fleck, John L. Bixby, Ajay M. Shah, Rotem Ben-Tov Perry, Vance Lemmon, Alexander N. Kapustin, Thomas L. Carroll, Simone Di Giovanni, Luming Zhou, Ilaria Palmisano, Guiping Kong
Publikováno v:
Nature Cell Biology. 20:307-319
Reactive oxygen species (ROS) contribute to tissue damage and remodelling mediated by the inflammatory response after injury. Here we show that ROS, which promote axonal dieback and degeneration after injury, are also required for axonal regeneration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ddb65841c81cd70c1687e39fb25f0f
https://doi.org/10.1038/s41556-018-0039-x
https://doi.org/10.1038/s41556-018-0039-x
Autor:
Matthias Epple, Yana Dautova, Kevin Pappert, Alexander N. Kapustin, Martin D. Bootman, Hanneke Okkenhaug, Diane Proudfoot, Simon J. Cook, Catherine M. Shanahan
Publikováno v:
Journal of Molecular and Cellular Cardiology
Dautova, Y, Kapustin, A, Pappert, K, Epple, M, Okkenhaug, H, Cook, S J, Shanahan, C M, Bootman, M D & Proudfoot, D 2017, ' Calcium phosphate particles stimulate interleukin-1β release from human vascular smooth muscle cells : A role for spleen tyrosine kinase and exosome release ', Journal of Molecular and Cellular Cardiology . https://doi.org/10.1016/j.yjmcc.2017.12.007
Dautova, Y, Kapustin, A, Pappert, K, Epple, M, Okkenhaug, H, Cook, S J, Shanahan, C M, Bootman, M D & Proudfoot, D 2017, ' Calcium phosphate particles stimulate interleukin-1β release from human vascular smooth muscle cells : A role for spleen tyrosine kinase and exosome release ', Journal of Molecular and Cellular Cardiology . https://doi.org/10.1016/j.yjmcc.2017.12.007
Aims Calcium phosphate (CaP) particle deposits are found in several inflammatory diseases including atherosclerosis and osteoarthritis. CaP, and other forms of crystals and particles, can promote inflammasome formation in macrophages leading to caspa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d86e001074dcd1dcf16d9ed519a5db8
http://europepmc.org/articles/PMC5823844
http://europepmc.org/articles/PMC5823844
Autor:
Ruifang Lu, Philipp Skroblin, Gerard Pasterkamp, Sarah R. Langley, Catherine M. Shanahan, Peter Willeit, Mariette Lengquist, Chris Molenaar, Joseph Shalhoub, Manuel Mayr, Alexander N. Kapustin, Ljubica Perisic Matic, Karin Willeit, Ulf Hedin, Claudia Monaco, Johann Willeit, Athanasios Didangelos, Bernhard Iglseder, Temo Barwari, Stefan Kiechl, Xiaoke Yin, Bernhard Paulweber, Javier Barallobre-Barreiro, Alun H. Davies, Ludmilla Kedenko, Gonca Suna, Gregor Rungger
Publikováno v:
The Journal of Clinical Investigation
Journal of Clinical Investigation, 127(4), 1546. The American Society for Clinical Investigation
Langley, S R, Willeit, K, Didangelos, A, Matic, L P, Skroblin, P, Barallobre-barreiro, J, Lengquist, M, Rungger, G, Kapustin, A, Kedenko, L, Molenaar, C, Lu, R, Barwari, T, Suna, G, Yin, X, Iglseder, B, Paulweber, B, Willeit, P, Shalhoub, J, Pasterkamp, G, Davies, A H, Monaco, C, Hedin, U, Shanahan, C M, Willeit, J, Kiechl, S & Mayr, M 2017, ' Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques ', Journal of Clinical Investigation, vol. 127, no. 4, pp. 1546-1560 . https://doi.org/10.1172/JCI86924
Journal of Clinical Investigation, 127(4), 1546. The American Society for Clinical Investigation
Langley, S R, Willeit, K, Didangelos, A, Matic, L P, Skroblin, P, Barallobre-barreiro, J, Lengquist, M, Rungger, G, Kapustin, A, Kedenko, L, Molenaar, C, Lu, R, Barwari, T, Suna, G, Yin, X, Iglseder, B, Paulweber, B, Willeit, P, Shalhoub, J, Pasterkamp, G, Davies, A H, Monaco, C, Hedin, U, Shanahan, C M, Willeit, J, Kiechl, S & Mayr, M 2017, ' Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques ', Journal of Clinical Investigation, vol. 127, no. 4, pp. 1546-1560 . https://doi.org/10.1172/JCI86924
Background The identification of patients with high-risk atherosclerotic plaques prior to the manifestation of clinical events remains challenging. Recent findings question histology- and imaging-based definitions of the "vulnerable plaque," necessit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06bd6507360d0b7346be45c1a632f84c
https://doi.org/10.1172/jci86924
https://doi.org/10.1172/jci86924
Publikováno v:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 374(1765)
Nucleic acids are a rapidly emerging therapeutic modality with the potential to become the third major drug modality alongside antibodies and small molecules. Owing to the unfavourable physico-chemical characteristics of nucleic acids, such as large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ee44350682a58ab523063c8e296ffc
https://pubmed.ncbi.nlm.nih.gov/30967005
https://pubmed.ncbi.nlm.nih.gov/30967005
Publikováno v:
The Journal of Physiology. 594:2905-2914
Vascular smooth muscle cell (VSMC) phenotypic conversion from a contractile to 'synthetic' state contributes to vascular pathologies including restenosis, atherosclerosis and vascular calcification. We have recently found that the secretion of exosom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::606f811c1f577cb5b374fcf94b9ccfb7
https://doi.org/10.1113/jp271340
https://doi.org/10.1113/jp271340
Autor:
Daniel Soong, Malgorzata Furmanik, Sean M. Davidson, Catherine M. Shanahan, Manuel Mayr, D Alvarez-Hernandez, Adrian H. Chester, Karin H. Müller, Chris P. M. Reutelingsperger, Alexander N. Kapustin, Leon J. Schurgers, Rafael Torres Martin de Rosales, Ignat Drozdov, Sergio Bertazzo, Jeremy N. Skepper, Martijn L. Chatrou, Rukshana Shroff, Ying Zheng, Pilar Sanchis, Xiaoke Yin
Publikováno v:
Circulation Research, 116(8), 1312-1323. LIPPINCOTT WILLIAMS & WILKINS
Rationale: Matrix vesicles (MVs), secreted by vascular smooth muscle cells (VSMCs), form the first nidus for mineralization and fetuin-A, a potent circulating inhibitor of calcification, is specifically loaded into MVs. However, the processes of fetu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa8fbe9115bbd1b233ff53387f29d048
https://doi.org/10.1161/circresaha.116.305012
https://doi.org/10.1161/circresaha.116.305012
Autor:
Eric S. Chemla, Juan Carlos Kaski, Nihil Chitalia, Prabir Roy-Chaudhury, Alexander N. Kapustin, Debasish Banerjee, Catherine M. Shanahan, Louise Ross, Mahesh Krishnamoorthy
Publikováno v:
Seminars in Dialysis. 28:E35-E40
The nature of arterial changes resulting in cardiovascular events and dialysis vascular access failures in adult predialysis patients is not well known. This study examined intimal changes, calcium deposition, and consequent stiffness in brachial and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19eecb403568178c9180013384fb6072
https://doi.org/10.1111/sdi.12335
https://doi.org/10.1111/sdi.12335