Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Alexander N. Freiberg"'
Autor:
Tetsuro Ikegami, Eduardo Jurado-Cobena, Cigdem Alkan, Jennifer K. Smith, Lihong Zhang, Birte Kalveram, Terry L. Juelich, Allen T. Esterly, Jahnavi R. Bhaskar, Saravanan Thangamani, Alexander N. Freiberg
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-12 (2022)
Abstract Rift Valley fever (RVF) is a mosquito-borne zoonosis endemic to Africa and the Arabian Peninsula, which causes large outbreaks among humans and ruminants. Single dose vaccinations using live-attenuated RVF virus (RVFV) support effective prev
Externí odkaz:
https://doaj.org/article/4e41bca749494ed99684009ae280a8e8
Publikováno v:
Viruses, Vol 15, Iss 11, p 2147 (2023)
Nipah virus (NiV; genus: Henipavirus; family: Paramyxoviridae) naturally infects Old World fruit bats (family Pteropodidae) without causing overt disease. Conversely, NiV infection in humans and other mammals can be lethal. Comparing bat antiviral re
Externí odkaz:
https://doaj.org/article/af6e44ad4fe941bcb71b15c8c885f3fd
Autor:
Olivier Escaffre, Terry L. Juelich, Jennifer K. Smith, Lihong Zhang, Nigel Bourne, Alexander N. Freiberg
Publikováno v:
Viruses, Vol 15, Iss 7, p 1590 (2023)
Ebola virus (EBOV) causes Ebola virus disease (EVD), which is characterized by hemorrhagic fever with high mortality rates in humans. EBOV sexual transmission has been a concern since the 2014–2016 outbreak in Africa, as persistent infection in the
Externí odkaz:
https://doaj.org/article/36b9c5fdf3ac412c9fa3bc3e76aab768
Autor:
Olivier Escaffre, Peter Szaniszlo, Gabor Törő, Caitlyn L. Vilas, Brenna J. Servantes, Ernesto Lopez, Terry L. Juelich, Corri B. Levine, Susan L. F. McLellan, Jessica C. Cardenas, Alexander N. Freiberg, Katalin Módis
Publikováno v:
Biomedicines, Vol 11, Iss 7, p 1790 (2023)
Recent studies have confirmed that lung microvascular endothelial injury plays a critical role in the pathophysiology of COVID-19. Our group and others have demonstrated the beneficial effects of H2S in several pathological processes and provided a r
Externí odkaz:
https://doaj.org/article/a9233483d50f4474bd1974b518a3c37c
Autor:
Adam Hage, Preeti Bharaj, Sarah van Tol, Maria I. Giraldo, Maria Gonzalez-Orozco, Karl M. Valerdi, Abbey N. Warren, Leopoldo Aguilera-Aguirre, Xuping Xie, Steven G. Widen, Hong M. Moulton, Benhur Lee, Jeffrey R. Johnson, Nevan J. Krogan, Adolfo García-Sastre, Pei-Yong Shi, Alexander N. Freiberg, Ricardo Rajsbaum
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110434- (2022)
Summary: Type I interferons (IFN-I) are essential to establish antiviral innate immunity. Unanchored (or free) polyubiquitin (poly-Ub) has been shown to regulate IFN-I responses. However, few unanchored poly-Ub interactors are known. To identify fact
Externí odkaz:
https://doaj.org/article/1021a0c2a2e14ca9810fefd46e1864bc
Autor:
Evelyn M. Covés-Datson, Steven R. King, Maureen Legendre, Michael D. Swanson, Auroni Gupta, Sandra Claes, Jennifer L. Meagher, Arnaud Boonen, Lihong Zhang, Birte Kalveram, Zoe Raglow, Alexander N. Freiberg, Mark Prichard, Jeanne A. Stuckey, Dominique Schols, David M. Markovitz
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Lectins, carbohydrate-binding proteins, have been regarded as potential antiviral agents, as some can bind glycans on viral surface glycoproteins and inactivate their functions. However, clinical development of lectins has been stalled by th
Externí odkaz:
https://doaj.org/article/283392a3b205412094e2427caa1508b6
Autor:
Mehdi Moustaqil, Emma Ollivier, Hsin-Ping Chiu, Sarah Van Tol, Paulina Rudolffi-Soto, Christian Stevens, Akshay Bhumkar, Dominic J. B. Hunter, Alexander N. Freiberg, David Jacques, Benhur Lee, Emma Sierecki, Yann Gambin
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 178-195 (2021)
The genome of SARS-CoV-2 encodes two viral proteases (NSP3/papain-like protease and NSP5/3C-like protease) that are responsible for cleaving viral polyproteins during replication. Here, we discovered new functions of the NSP3 and NSP5 proteases of SA
Externí odkaz:
https://doaj.org/article/abb04dd2b53e469d9a1bf3b2624c8bc7
Autor:
Kassandra L. Carpio, Jill K. Thompson, Steven G. Widen, Jennifer K. Smith, Terry L. Juelich, David E. Clements, Alexander N. Freiberg, Alan D. T. Barrett
Publikováno v:
Viruses, Vol 15, Iss 2, p 281 (2023)
The genetic diversities of mammalian tick-borne flaviviruses are poorly understood. We used next-generation sequencing (NGS) to deep sequence different viruses and strains belonging to this group of flaviviruses, including Central European tick-borne
Externí odkaz:
https://doaj.org/article/f0bc9e970712431cb02569b6b9fee9c6
Autor:
Jacob Nelson, Lorenzo Ochoa, Paula Villareal, Tiffany Dunn, Ping Wu, Gracie Vargas, Alexander N. Freiberg
Publikováno v:
Pathogens, Vol 11, Iss 10, p 1218 (2022)
Powassan virus (POWV) is a tick-borne flavivirus (TBFV) that can cause severe encephalitis in humans with a case–fatality rate as high as 11%. Patients who survive severe encephalitic disease can develop long-term neurological sequelae that can be
Externí odkaz:
https://doaj.org/article/3e0c6a951fa44c78a82b906c095165c8
Autor:
Brian E. Dawes, Junling Gao, Colm Atkins, Jacob T. Nelson, Kendra Johnson, Ping Wu, Alexander N. Freiberg
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-15 (2018)
Abstract Background La Crosse virus (LACV) causes pediatric encephalitis in the USA. LACV induces severe inflammation in the central nervous system, but the recruitment of inflammatory cells is poorly understood. A deeper understanding of LACV-induce
Externí odkaz:
https://doaj.org/article/8a12876165c045f8b34e2a025c4c2166