Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Alexander N Yatsenko"'
Autor:
Olga Kim, Eun Young Park, David L Klinkebiel, Svetlana D Pack, Yong-Hyun Shin, Zied Abdullaev, Robert E Emerson, Donna M Coffey, Sun Young Kwon, Chad J Creighton, Sanghoon Kwon, Edmund C Chang, Theodore Chiang, Alexander N Yatsenko, Jeremy Chien, Dong-Joo Cheon, Yang Yang-Hartwich, Harikrishna Nakshatri, Kenneth P Nephew, Richard R Behringer, Facundo M Fernández, Chi-Heum Cho, Barbara Vanderhyden, Ronny Drapkin, Robert C Bast, Kathy D Miller, Adam R Karpf, Jaeyeon Kim
Publikováno v:
PLoS Genetics, Vol 16, Iss 6, p e1008808 (2020)
Metastasis is responsible for 90% of human cancer mortality, yet it remains a challenge to model human cancer metastasis in vivo. Here we describe mouse models of high-grade serous ovarian cancer, also known as high-grade serous carcinoma (HGSC), the
Externí odkaz:
https://doaj.org/article/a0866ddae28348acb288e0a6cd580d54
Autor:
Agnieszka Malcher, Zuzanna Graczyk, Hermann Bauer, Tomasz Stokowy, Andrea Berman, Mikołaj Smolibowski, Dominika Blaszczyk, Piotr Jedrzejczak, Alexander N. Yatsenko, Maciej Kurpisz
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Infertility is a problem that affects approximately 15% of couples, and male infertility is responsible for 40–50% of these cases. The cause of male infertility is still poorly diagnosed and treated. One of the prominent causes of male inf
Externí odkaz:
https://doaj.org/article/3d4d30706a7146169ea59dfc53471e2b
Autor:
Sidra Qureshi, Jimmaline J. Hardy, Christopher Pombar, Andrea J. Berman, Agnieszka Malcher, Tara Gingrich, Rachel Hvasta, Jannah Kuong, Sarah Munyoki, Kathleen Hwang, Kyle E. Orwig, Jawad Ahmed, Marta Olszewska, Maciej Kurpisz, Donald F. Conrad, Muhammad Jaseem Khan, Alexander N. Yatsenko
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Introduction: Human spermatogenesis is a highly intricate process that requires the input of thousands of testis-specific genes. Defects in any of them at any stage of the process can have detrimental effects on sperm production and/or viability. In
Externí odkaz:
https://doaj.org/article/f19d435c49704442b8cbf60dc260f687
Autor:
Marta Olszewska, Agnieszka Malcher, Tomasz Stokowy, Nijole Pollock, Andrea J. Berman, Sylwia Budkiewicz, Marzena Kamieniczna, Hanna Jackowiak, Piotr Jedrzejczak, Alexander N. Yatsenko, Maciej Kurpisz
STUDY QUESTIONIsTcte1mutation causative for male infertility?SUMMARY ANSWERCollected data underline the complex and devastating effect of the single-gene mutation on testicular molecular network, leading to male reproductive failure.WHAT IS KNOWN ALR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03174a00a9f73392e2b7a61f5f6b5a92
https://doi.org/10.1101/2022.11.17.22282339
https://doi.org/10.1101/2022.11.17.22282339
Autor:
Agnieszka Malcher, Tomasz Stokowy, Andrea Berman, Marta Olszewska, Piotr Jedrzejczak, Dawid Sielski, Adam Nowakowski, Natalia Rozwadowska, Alexander N. Yatsenko, Maciej K. Kurpisz
Publikováno v:
Andrology
Background: Genetic causes that lead to spermatogenetic failure in patients with nonobstructive azoospermia (NOA) have not been yet completely established. Objective: To identify low-frequency NOA-associated single nucleotide variants (SNVs) using wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ed1dc809b8aad8c7c89250c79a1897
https://hdl.handle.net/11250/3045447
https://hdl.handle.net/11250/3045447
Autor:
Nijole Pollock, Nataliya Huleyuk, Danuta Zastavna, Marta Olszewska, Andrew Georgiadis, Maciej Kurpisz, Tomasz Stokowy, Alexander N. Yatsenko, Svetlana A. Yatsenko
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 4559, p 4559 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Structural aberrations involving more than two breakpoints on two or more chromosomes are known as complex chromosomal rearrangements (CCRs). They can reduce fertility through gametogenesis arrest developed due to disrupted chromosomal pairing in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39104d5382e7210363f47e8964a17fe7
https://www.mdpi.com/1422-0067/21/12/4559
https://www.mdpi.com/1422-0067/21/12/4559
Autor:
Courtney D. Goldstein, Rahul K. Kollipara, Michael Buszczak, Kim Orth, Murtaza Ahmed, Kelly A. Servage, Amanda K. Casey, James F. Amatruda, Ralf Kittler, Wei Li, Zachary Picciarelli, Varsha Bhargava, Alexander N. Yatsenko, Logan Russell, Judith L. Yanowitz, Michelle A. Carmell, Lin Xu
Publikováno v:
Dev Cell
SUMMARYThe propagation of species depends on the ability of germ cells to protect their genome in the face of numerous exogenous and endogenous threats. While these cells employ a number of known repair pathways, specialized mechanisms that ensure hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044c2f30ef9f21bd12489963fed96110
https://europepmc.org/articles/PMC6946843/
https://europepmc.org/articles/PMC6946843/
Autor:
Alexander N. Yatsenko, Paul J. Turek
Publikováno v:
Journal of Assisted Reproduction and Genetics. 35:933-941
PURPOSE: To examine current evidence of the known effects of advanced paternal age on sperm genetic and epigenetic changes and associated birth defects and diseases in offspring. METHODS: Review of published PubMed literature. RESULTS: Advanced pater
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30c350d3f6884863859a0c08210134b2
https://doi.org/10.1007/s10815-018-1148-y
https://doi.org/10.1007/s10815-018-1148-y
Autor:
Rubina Nazli, Carlos A. Castro, Sulman Basit, Aleksandar Rajkovic, Muhammad Jaseem Khan, Alexander N. Yatsenko, Jawad Ahmed, Huaiyang Jiang, Nijole Pollock
Publikováno v:
Scientific reports, vol 8, iss 1
Scientific Reports
Khan, Muhammad Jaseem; Pollock, Nijole; Jiang, Huaiyang; Castro, Carlos; Nazli, Rubina; Ahmed, Jawad; et al.(2018). X-linked ADGRG2 mutation and obstructive azoospermia in a large Pakistani family. SCIENTIFIC REPORTS, 8(1), 16280. doi: 10.1038/s41598-018-34262-5. UCSF: Retrieved from: http://www.escholarship.org/uc/item/4jq4w51c
Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
Scientific Reports
Khan, Muhammad Jaseem; Pollock, Nijole; Jiang, Huaiyang; Castro, Carlos; Nazli, Rubina; Ahmed, Jawad; et al.(2018). X-linked ADGRG2 mutation and obstructive azoospermia in a large Pakistani family. SCIENTIFIC REPORTS, 8(1), 16280. doi: 10.1038/s41598-018-34262-5. UCSF: Retrieved from: http://www.escholarship.org/uc/item/4jq4w51c
Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
We performed whole exome sequencing to identify an unknown genetic cause of azoospermia and male infertility in a large Pakistani family. Three infertile males were subjected to semen analysis, hormone testing, testicular histology, ultrasonography,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4b76be5218674e8e4aa48428c8f979
https://escholarship.org/uc/item/4jq4w51c
https://escholarship.org/uc/item/4jq4w51c
Autor:
A.C. Zielen, Nijole Pollock, Alexander N. Yatsenko, Aleksandar Rajkovic, Jawad Ahmed, Musarrat Jabeen, Muhammad Jaseem Khan, Rubina Nazli, Huaiyang Jiang
[Image: see text]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b29a0b9ae54f3a9297255b001a5d19
https://europepmc.org/articles/PMC6456337/
https://europepmc.org/articles/PMC6456337/