Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Alexander N R, Weber"'
Autor:
Maximilian Bellut, Michael Bieber, Peter Kraft, Alexander N. R. Weber, Guido Stoll, Michael K. Schuhmann
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-10 (2023)
Abstract Background Ischemic stroke immediately evokes a strong neuro-inflammatory response within the vascular compartment, which contributes to primary infarct development under vessel occlusion as well as further infarct growth despite recanalizat
Externí odkaz:
https://doaj.org/article/b07d3dec5ac44a9a93d01fbfd489fe2a
Autor:
Shreya Bhattacharya, Alec Jacob Maupin, Anders Grønnegaard Schlosser, Ernst-Martin Füchtbauer, Yamel Cardona Gloria, Alexander N R Weber, Uffe Holmskov, Jesper Bonnet Moeller, Steven P Templeton
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0282347 (2023)
Chitin, a polysaccharide, is ubiquitously found in nature and has been known to be an active immunogen in mammals, and interacts with Toll-like, mannose and glucan receptors, to induce cytokine and chemokine secretions. FIBCD1 is a tetrameric type II
Externí odkaz:
https://doaj.org/article/4139864ba14240e6bd5d4d61ecd9daf4
Autor:
Calogerina Catalano, Miguel Inacio daSilva Filho, Christoph Frank, Shun Lu, Katerina Jiraskova, Veronika Vymetalkova, Miroslav Levy, Vaclav Liska, Ondrej Vycital, Alessio Naccarati, Ludmila Vodickova, Kari Hemminki, Pavel Vodicka, Alexander N. R. Weber, Asta Försti
Publikováno v:
Cancer Medicine, Vol 9, Iss 4, Pp 1473-1484 (2020)
Abstract Objective The TLR3/cGAS‐STING‐IFN signaling has recently been reported to be disturbed in colorectal cancer due to deregulated expression of the genes involved. Our study aimed to investigate the influence of potential regulatory variant
Externí odkaz:
https://doaj.org/article/423bf235f78741dfab8084a24afca3b0
Autor:
Franziska Herster, Zsofia Bittner, Nathan K. Archer, Sabine Dickhöfer, David Eisel, Tatjana Eigenbrod, Thomas Knorpp, Nicole Schneiderhan-Marra, Markus W. Löffler, Hubert Kalbacher, Tim Vierbuchen, Holger Heine, Lloyd S. Miller, Dominik Hartl, Lukas Freund, Knut Schäkel, Martin Heister, Kamran Ghoreschi, Alexander N. R. Weber
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Antimicrobial peptide LL37 can bind nucleic acids and potentiate their sensing by endosomal TLRs. Here the authors show that LL37 binds to RNA from neutrophil extracellular traps (NETs), which amplifies inflammation and production of more LL37 and NE
Externí odkaz:
https://doaj.org/article/ea97f7082ce74177a2af8db079fd79c4
Autor:
Jurica Baranašić, Maja Šutić, Calogerina Catalano, Gordana Drpa, Stefanie Huhn, Dragomira Majhen, Davor Nestić, Matea Kurtović, Lada Rumora, Martina Bosnar, Andrea Vukić Dugac, Irena Sokolović, Sanja Popovic-Grle, Nada Oršolić, Sanda Škrinjarić-Cincar, Marko Jakopović, Miroslav Samaržija, Alexander N. R. Weber, Asta Försti, Jelena Knežević
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2240 (2022)
Chronic obstructive pulmonary disease (COPD) is considered as the strongest independent risk factor for lung cancer (LC) development, suggesting an overlapping genetic background in both diseases. A common feature of both diseases is aberrant immunit
Externí odkaz:
https://doaj.org/article/ccb4ae45540b4b99886d9925afe4d343
Autor:
Yamel Cardona Gloria, Stephan H. Bernhart, Sven Fillinger, Olaf-Oliver Wolz, Sabine Dickhöfer, Jakob Admard, Stephan Ossowski, Sven Nahnsen, Reiner Siebert, Alexander N. R. Weber
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Gain-of-function mutations of the TLR adaptor and oncoprotein MyD88 drive B cell lymphomagenesis via sustained NF-κB activation. In myeloid cells, both short and sustained TLR activation and NF-κB activation lead to the induction of inhibitory MYD8
Externí odkaz:
https://doaj.org/article/0caf074eea2a4d48b980452ed8e1c053
Autor:
Hans-Georg Rammensee, Karl-Heinz Wiesmüller, P. Anoop Chandran, Henning Zelba, Elisa Rusch, Cécile Gouttefangeas, Daniel J. Kowalewski, Moreno Di Marco, Sebastian P. Haen, Juliane S. Walz, Yamel Cardona Gloria, Johanna Bödder, Jill-Marie Schertel, Antje Tunger, Luise Müller, Maximilian Kießler, Rebekka Wehner, Marc Schmitz, Meike Jakobi, Nicole Schneiderhan-Marra, Reinhild Klein, Karoline Laske, Kerstin Artzner, Linus Backert, Heiko Schuster, Johannes Schwenck, Alexander N. R. Weber, Bernd J. Pichler, Manfred Kneilling, Christian la Fougère, Stephan Forchhammer, Gisela Metzler, Jürgen Bauer, Benjamin Weide, Wilfried Schippert, Stefan Stevanović, Markus W. Löffler
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-18 (2019)
Abstract Background We previously showed that the bacterial lipopeptide Pam3Cys-Ser-Ser, meanwhile established as a toll-like receptor (TLR) 1/2 ligand, acts as a strong adjuvant for the induction of virus specific CD8+ T cells in mice, when covalent
Externí odkaz:
https://doaj.org/article/cc3a16412b7c49e5953df66f2cd4dccd
Autor:
Patrick Münzer, Roberto Negro, Shoichi Fukui, Lucas di Meglio, Karen Aymonnier, Long Chu, Deya Cherpokova, Sarah Gutch, Nicoletta Sorvillo, Lai Shi, Venkat Giri Magupalli, Alexander N. R. Weber, Rüdiger E. Scharf, Clare M. Waterman, Hao Wu, Denisa D. Wagner
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Neutrophil extracellular trap formation (NETosis) and the NLR family pyrin domain containing 3 (NLRP3) inflammasome assembly are associated with a similar spectrum of human disorders. While NETosis is known to be regulated by peptidylarginine deimina
Externí odkaz:
https://doaj.org/article/2d05e129ea374b9f8cb826c28431c42d
Autor:
Alexander N. R. Weber
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The NLRP3 inflammasome represents a critical inflammatory machinery driving pathology in many acute (e. g., myocardial infarction or stroke) and chronic (Alzheimer's disease, atherosclerosis) human disorders linked to the activity of IL-1 cytokines.
Externí odkaz:
https://doaj.org/article/1fa40cd374b84241ac0e35d5d7abe5ef
Autor:
Franziska Herster, Zsofia Bittner, Marius Cosmin Codrea, Nathan K. Archer, Martin Heister, Markus W. Löffler, Simon Heumos, Joanna Wegner, Ramona Businger, Michael Schindler, David Stegner, Knut Schäkel, Stephan Grabbe, Kamran Ghoreschi, Lloyd S. Miller, Alexander N. R. Weber
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Psoriasis is a frequent systemic inflammatory autoimmune disease characterized primarily by skin lesions with massive infiltration of leukocytes, but frequently also presents with cardiovascular comorbidities. Especially polymorphonuclear neutrophils
Externí odkaz:
https://doaj.org/article/8dd172ca07bd406789dc6f14dcbecf2e