Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Alexander N Plotnikov"'
Autor:
Hong Wu, Jinrong Min, Vladimir V Lunin, Tatiana Antoshenko, Ludmila Dombrovski, Hong Zeng, Abdellah Allali-Hassani, Valérie Campagna-Slater, Masoud Vedadi, Cheryl H Arrowsmith, Alexander N Plotnikov, Matthieu Schapira
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8570 (2010)
SET domain methyltransferases deposit methyl marks on specific histone tail lysine residues and play a major role in epigenetic regulation of gene transcription. We solved the structures of the catalytic domains of GLP, G9a, Suv39H2 and PRDM2, four o
Externí odkaz:
https://doaj.org/article/95096d2b7d904bb19f1e153028ae1d82
Autor:
Qiang Zhang, Suvobrata Chakravarty, Dario Ghersi, Lei Zeng, Alexander N Plotnikov, Roberto Sanchez, Ming-Ming Zhou
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8903 (2010)
It has been shown that molecular interactions between site-specific chemical modifications such as acetylation and methylation on DNA-packing histones and conserved structural modules present in transcriptional proteins are closely associated with ch
Externí odkaz:
https://doaj.org/article/18574d87b39e4e45ab17c2dc358361d1
Autor:
Keith I Pardee, Xiaohui Xu, Jeff Reinking, Anja Schuetz, Aiping Dong, Suya Liu, Rongguang Zhang, Jens Tiefenbach, Gilles Lajoie, Alexander N Plotnikov, Alexey Botchkarev, Henry M Krause, Aled Edwards
Publikováno v:
PLoS Biology, Vol 7, Iss 2, p e43 (2009)
Heme is a ligand for the human nuclear receptors (NR) REV-ERBalpha and REV-ERBbeta, which are transcriptional repressors that play important roles in circadian rhythm, lipid and glucose metabolism, and diseases such as diabetes, atherosclerosis, infl
Externí odkaz:
https://doaj.org/article/d76afef7ed9440828f6f21f6b78d7b15
Autor:
Abdellah Allali-Hassani, Patricia W Pan, Ludmila Dombrovski, Rafael Najmanovich, Wolfram Tempel, Aiping Dong, Peter Loppnau, Fernando Martin, Janet Thornton, Aled M Edwards, Alexey Bochkarev, Alexander N Plotnikov, Masoud Vedadi, Cheryl H Arrowsmith
Publikováno v:
PLoS Biology, Vol 5, Iss 5, p e97 (2007)
The human cytosolic sulfotransfases (hSULTs) comprise a family of 12 phase II enzymes involved in the metabolism of drugs and hormones, the bioactivation of carcinogens, and the detoxification of xenobiotics. Knowledge of the structural and mechanist
Externí odkaz:
https://doaj.org/article/b16aa60a578740d2ac8dcb3a1c09342a
Autor:
Geming Lu, Ruihua Zhang, Liang Peng, Rajal Sharma, Feihong Xu, Qiang Zhang, Ying Ju, Lei Zeng, Tong Shen, Martin J. Walsh, Huabao Xiong, Yuan Hu, Anbalagan Jaganathan, Ming-Ming Zhou, Jianjun Yang, Ka-lung Cheung, Fan Zhang, Adam Vincek, Xinye Han, Michael Ohlmeyer, Jamel Meslamani, Hongfa Zhu, Elena Rusinova, David Y. Zhang, Li Zhao, Jiachi Zhou, Alexander N. Plotnikov
Publikováno v:
Proceedings of the National Academy of Sciences. 114:2952-2957
T-helper 17 (Th17) cells have important functions in adaptor immunity and have also been implicated in inflammatory disorders. The bromodomain and extraterminal domain (BET) family proteins regulate gene transcription during lineage-specific differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6df2376b49dfcd5a560c5874eb1a97
https://doi.org/10.1073/pnas.1615601114
https://doi.org/10.1073/pnas.1615601114
Autor:
Alexander N. Plotnikov, Haim Barr, S. Velupillai, T. Krojer, Jingxu Guo, Jinrui Gan, Huib Ovaa, Oleg Fedorov, Christopher G. Dowson, Gian Filippo Ruda, R. Sethi, Chu Wang, Michael Fairhead, Ronen Gabizon, Nava Reznik, Gabriel Amitai, Daniel Zaidman, T. Szommer, James Bennett, Dom Bellini, Nir London, Paul P. Geurink, Efrat Resnick, Anthony Aimon, Verena M. Straub, Anthony R. Bradley, Frank von Delft, Y. Zhang, Alun R. Coker, Alice Douangamath, Laura Diaz Saez, Paul Brennan, Kilian Huber, Jin Gan
Publikováno v:
Journal of the American Chemical Society, 141(22), 8951-8968
Journal of the American Chemical Society, 141(22), 8951-8968. AMER CHEMICAL SOC
Journal of the American Chemical Society, 141(22), 8951-8968. AMER CHEMICAL SOC
[Image: see text] Covalent probes can display unmatched potency, selectivity, and duration of action; however, their discovery is challenging. In principle, fragments that can irreversibly bind their target can overcome the low affinity that limits r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc5c370637dd62cafe589b277a9c578
http://wrap.warwick.ac.uk/119286/1/WRAP-rapid-covalent-probe-discovery-electrophile-fragment-screening-Dowson-2019.pdf
http://wrap.warwick.ac.uk/119286/1/WRAP-rapid-covalent-probe-discovery-electrophile-fragment-screening-Dowson-2019.pdf
Autor:
R. Sethi, Alun R. Coker, Laura Diaz Saez, Paul Brennan, Kilian Huber, Huib Ovaa, Alexander N. Plotnikov, Gian Filippo Ruda, Dom Bellini, James Bennett, Michael Fairhead, rikannathasan Velupillai, Daniel Zaidman, Frank von Delft, Anthony R. Bradley, Nava Reznik, Haim Barr, T. Szommer, Jingxu Guo, Paul P. Geurink, Nir London, Alice Douangamath, Jinrui Gan, Gabriel Amitai, Anthony Aimon, Efrat Resnick, Verena M. Straub, T. Krojer, Oleg Fedorov, Christopher G. Dowson
Covalent probes can display unmatched potency, selectivity and duration of action, however, their discovery is challenging. In principle, fragments that can irreversibly bind their target can overcome the low affinity that limits reversible fragment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2e3f5bc3e57d245c704b16130f4040
Autor:
Andrey V. Reshetnyak, Navjot Kaur, David E. Puleo, Mansoor Ahmed, Anton Poliakov, Alexander N. Plotnikov, Francisco Tome, Joseph Schlessinger, Jyotidarsini Mohanty, Irit Lax, Arul M. Cinnaiyan
Elucidating the physiological roles and modes of action of the recently discovered ligands (designated ALKAL1,2 or AUG-α,β) of the receptor tyrosine kinases Anaplastic Lymphoma Kinase (ALK) and Leukocyte Tyrosine Kinase (LTK) has been limited by di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7afaee2d35c44ce508c4d87139b69053
https://europepmc.org/articles/PMC6099872/
https://europepmc.org/articles/PMC6099872/
Autor:
Jasbir Kaur, Bridget Matikainen, Gregory Moy, Ming-Ming Zhou, Patrizia Casaccia, Yoel Rodríguez, Lei Zeng, Guillermo Gerona-Navarro, Alexander N. Plotnikov, Adam Vincek, Mar Gacias, Guangtao Zhang, Elena Rusinova, Jennifer Joshua
Publikováno v:
Chemistry & Biology. 21(7):841-854
Lysine acetylation regulates gene expression through modulating protein-protein interactions in chromatin. Chemical inhibition of acetyl-lysine binding bromodomains of the major chromatin regulators BET (bromodomain and extra-terminal domain) protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce44cc5e3d453a1274197462e942fa5
Autor:
Shuai Yang, Antonio Frasca, Thomas Jiachi Zhou, Alexander N. Plotnikov, Ming-Ming Zhou, Elena Rusinova
Publikováno v:
Structure. 22:353-360
SummaryBromodomain functions as the acetyl-lysine binding domains to regulate gene transcription in chromatin. Bromodomains are rapidly emerging as new epigenetic drug targets for human diseases. However, owing to their transient nature and modest af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f916da33b01cb6c742aeb1e85cedbc
https://doi.org/10.1016/j.str.2013.10.021
https://doi.org/10.1016/j.str.2013.10.021