Výsledky vyhledávání - "Alexander Morokutti"

Akademický článek

Single HA2 mutation increases the infectivity and immunogenicity of a live attenuated H5N1 intranasal influenza vaccine candidate lacking NS1.

Publikováno v: PLoS ONE, Vol 6, Iss 4, p e18577 (2011)

BACKGROUND: H5N1 influenza vaccines, including live intranasal, appear to be relatively less immunogenic compared to seasonal analogs. The main influenza virus surface glycoprotein hemagglutinin (HA) of highly pathogenic avian influenza viruses (HPAI

Externí odkaz: https://doaj.org/article/d9c2e3f4d7b94f30b4cd05496ba9f848

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Akademický článek

Preclinical evaluation of a replication-deficient intranasal DeltaNS1 H5N1 influenza vaccine.

Publikováno v: PLoS ONE, Vol 4, Iss 6, p e5984 (2009)

BACKGROUND:We developed a novel intranasal influenza vaccine approach that is based on the construction of replication-deficient vaccine viruses that lack the entire NS1 gene (DeltaNS1 virus). We previously showed that these viruses undergo abortive

Externí odkaz: https://doaj.org/article/b3e0973ffb1a4402a23935312dac8bf4

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A Novel Type of Influenza Vaccine: Safety and Immunogenicity of Replication‐Deficient Influenza Virus Created by Deletion of the Interferon Antagonist NS1

Publikováno v: The Journal of Infectious Diseases. 201:354-362

BACKGROUND. The nonstructural protein NS1 of influenza virus counteracts the interferon-mediated immune response of the host. By deleting the open reading frame of NS1, we have generated a novel type of influenza vaccine. We studied the safety and im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d9ba66d2c39936b86589f617c6aa1d
https://doi.org/10.1086/649428

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Development of a live-attenuated influenza B ΔNS1 intranasal vaccine candidate

Autor: Sabine Nakowitsch, Manfred Reiter, Nina Wressnigg, Johannes Humer, Tanja Ruthsatz, Alexander Morokutti, Ines Mayerhofer, Thorsten Wolff, Andrej Egorov, Christian Kittel, Daniel Voss, Julia Romanova, Thomas Muster

Publikováno v: Vaccine. 27:2851-2857

We discovered a unique, single amino acid mutation in the influenza B M1 protein promoting viral growth of NS1 truncation mutants in Vero cells. Due to this mutation, we were able to generate an influenza B virus lacking the complete NS1 open reading

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b828b5714c1d3c95322f9859ba21d807
https://doi.org/10.1016/j.vaccine.2009.02.087

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Intranasal vaccination with a replication-deficient influenza virus induces heterosubtypic neutralising mucosal IgA antibodies in humans

Autor: Thomas Muster, Alexander Morokutti, Boris Ferko

Publikováno v: Vaccine. 32(17)

We investigated the cross-neutralising potential of serum and nasal wash samples from volunteers who were intranasally immunised once with a monovalent replication-deficient delNS1-H1N1 influenza virus vaccine (7.7 log 10 TCID 50 /volunteer). Eight o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892a244917b1695709b516d470df1c88
https://pubmed.ncbi.nlm.nih.gov/24560674

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Validation of the modified hemagglutination inhibition assay (mHAI), a robust and sensitive serological test for analysis of influenza virus-specific immune response

Autor: Sabine Nakowitsch, Boris Ferko, Alois Jungbauer, Theresia Popow-Kraupp, Alexander Morokutti, Julia Romanova, Monika Redlberger-Fritz, Brigitte M. Krenn, Thomas Muster, Nina Wressnigg

Publikováno v: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 56(4)

Background The hemagglutination inhibition assay (HAI) is universally regarded as the gold standard in influenza virus serology. Nevertheless, difficulties in titre readouts are common and interlaboratory variations are frequently reported. Objective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c81135040e34f958d1e89933557a3bd
https://pubmed.ncbi.nlm.nih.gov/23375739

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Single HA2 mutation increases the infectivity and immunogenicity of a live attenuated H5N1 intranasal influenza vaccine candidate lacking NS1

Publikováno v: PLoS ONE
PLoS ONE, Vol 6, Iss 4, p e18577 (2011)

Background: H5N1 influenza vaccines, including live intranasal, appear to be relatively less immunogenic compared to seasonal analogs. The main influenza virus surface glycoprotein hemagglutinin (HA) of highly pathogenic avian influenza viruses (HPAI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de319f92c92e7cf15251e4a3d404035
https://pubmed.ncbi.nlm.nih.gov/21490925

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Structure and function of YcnD from Bacillus subtilis, a flavin-containing oxidoreductase

Autor: Karl Gruber, Thérésa Bridget Fitzpatrick, Christoph Kratky, Alexander Morokutti, Peter Macheroux, Andrzej Franciszek Lyskowski, Sonja Sollner, Eva Maria Pointner

Publikováno v: Biochemistry, Vol. 44, No 42 (2005) pp. 13724-33

YcnD from the gram-positive bacterium Bacillus subtilis is a member of a family of bacterial proteins that act as NADH- and/or NADPH-dependent oxidoreductases. Here, we report for the first time on the biochemical characterization of the purified pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c6f5ad04ea7c97deb4aba059e5d6d2
https://archive-ouverte.unige.ch/unige:89529

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Preclinical Evaluation of a Replication-Deficient Intranasal ΔNS1 H5N1 Influenza Vaccine

Publikováno v: PLoS ONE
PLoS ONE, Vol 4, Iss 6, p e5984 (2009)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a268857b16dae43b37638fdabaf3b4e
https://doi.org/10.1371/journal.pone.0005984

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