Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Alexander Milbradt"'
Publikováno v:
ADMET and DMPK, Vol 7, Iss 4, Pp 222-241 (2019)
Biophysical methods such as mass spectrometry, surface plasmon resonance, nuclear magnetic resonance, and both differential scanning isothermal titration calorimetry are now well established as key components of the early drug discovery process. Thes
Externí odkaz:
https://doaj.org/article/890ecf9ee33d441aa6e596338e21e865
Autor:
Jon J. Winter-Holt, Catherine Bardelle, Elisabetta Chiarparin, Ian L. Dale, Paul R. J. Davey, Nichola L. Davies, Christopher Denz, Shaun M. Fillery, Carine M. Guérot, Fujin Han, Samantha J. Hughes, Meghana Kulkarni, Zhaoqun Liu, Alexander Milbradt, Thomas A. Moss, Huijun Niu, Joe Patel, Alfred A. Rabow, Marianne Schimpl, Junjie Shi, Dongqing Sun, Dejian Yang, Sylvie Guichard
Publikováno v:
Journal of medicinal chemistry. 65(4)
ATAD2 is an epigenetic bromodomain-containing target which is overexpressed in many cancers and has been suggested as a potential oncology target. While several small molecule inhibitors have been described in the literature, their cellular activity