Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Alexander Merleev"'
1
Akademický článek
Systemic immunostimulation induces glucocorticoid-mediated thymic involution succeeded by rebound hyperplasia which is impaired in aged recipients
Autor: Craig P. Collins, Lam T. Khuat, Gail D. Sckisel, Logan V. Vick, Christine M. Minnar, Cordelia Dunai, Catherine T. Le, Brendan D. Curti, Marka Crittenden, Alexander Merleev, Michael Sheng, Nelson J. Chao, Emanual Maverakis, Spencer R. Rosario, Arta M. Monjazeb, Bruce R. Blazar, Dan L. Longo, Robert J. Canter, William J. Murphy
Publikováno v: Frontiers in Immunology, Vol 15 (2024)
The thymus is the central organ involved with T-cell development and the production of naïve T cells. During normal aging, the thymus undergoes marked involution, reducing naïve T-cell output and resulting in a predominance of long-lived memory T c
Externí odkaz: https://doaj.org/article/1e288536df9248b1a327800dd3a6007e
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3
Akademický článek
Virally encoded interleukin-6 facilitates KSHV replication in monocytes and induction of dysfunctional macrophages.
Autor: Michiko Shimoda, Tomoki Inagaki, Ryan R Davis, Alexander Merleev, Clifford G Tepper, Emanual Maverakis, Yoshihiro Izumiya
Publikováno v: PLoS Pathogens, Vol 19, Iss 10, p e1011703 (2023)
Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic double-stranded DNA virus and the etiologic agent of Kaposi's sarcoma and hyperinflammatory lymphoproliferative disorders. Understanding the mechanism by which KSHV increases the infected
Externí odkaz: https://doaj.org/article/7d4872c8ed57458a9aebba3bd44da5bb
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4
Akademický článek
Proprotein convertase subtilisin/kexin type 9 is a psoriasis-susceptibility locus that is negatively related to IL36G
Autor: Alexander Merleev, Antonio Ji-Xu, Atrin Toussi, Lam C. Tsoi, Stephanie T. Le, Guillaume Luxardi, Xianying Xing, Rachael Wasikowski, William Liakos, Marie-Charlotte Brüggen, James T. Elder, Iannis E. Adamopoulos, Yoshihiro Izumiya, Annie R. Leal, Qinyuan Li, Nikolay Y. Kuzminykh, Amanda Kirane, Alina I. Marusina, Johann E. Gudjonsson, Emanual Maverakis
Publikováno v: JCI Insight, Vol 7, Iss 16 (2022)
Proprotein convertase subtilisin/kexin type-9 (PCSK9) is a posttranslational regulator of the LDL receptor (LDLR). Recent studies have proposed a role for PCSK9 in regulating immune responses. Using RNA-Seq–based variant discovery, we identified a
Externí odkaz: https://doaj.org/article/0af5f0392e5144bb91cb11d1e06f87ed
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5
Akademický článek
Transcriptome analysis of human dermal fibroblasts following red light phototherapy
Autor: Evan Austin, Eugene Koo, Alexander Merleev, Denis Torre, Alina Marusina, Guillaume Luxardi, Andrew Mamalis, Roslyn Rivkah Isseroff, Avi Ma’ayan, Emanual Maverakis, Jared Jagdeo
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Fibrosis occurs when collagen deposition and fibroblast proliferation replace healthy tissue. Red light (RL) may improve skin fibrosis via photobiomodulation, the process by which photosensitive chromophores in cells absorb visible or near-i
Externí odkaz: https://doaj.org/article/1a227c143dba4b9495dc0bf4c116257c
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6
Akademický článek
A Comparison of Ex Vivo Expanded Human Regulatory T Cells Using Allogeneic Stimulated B Cells or Monocyte-Derived Dendritic Cells
Autor: Linda M. Lee, Hong Zhang, Karim Lee, Horace Liang, Alexander Merleev, Flavio Vincenti, Emanual Maverakis, Angus W. Thomson, Qizhi Tang
Publikováno v: Frontiers in Immunology, Vol 12 (2021)
Alloreactive regulatory T cells (arTregs) are more potent than polyclonal Tregs at suppressing immune responses to transplant antigens. Human arTregs can be expanded with allogeneic CD40L-stimulated B cells (sBcs) or stimulated-matured monocyte-deriv
Externí odkaz: https://doaj.org/article/9d418a90dcc64e0eb0b0d4191628aa1e
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7
Akademický článek
No Causal Link between Phosphodiesterase Type 5 Inhibition and Melanoma
Autor: Jenny Z. Wang, Stephanie Le, Claire Alexanian, Sucharita Boddu, Alexander Merleev, Alina Marusina, Emanual Maverakis
Publikováno v: The World Journal of Men's Health, Vol 37, Iss 3, Pp 313-321 (2019)
USAPurpose: To examine the association between phosphodiesterase type 5 (PDE5) inhibitor use and melanoma by 1) conducting a systematic review of observational studies; and 2) determining if low PDE5A gene expression in human melanoma correlated with
Externí odkaz: https://doaj.org/article/ff8b6e713ca34141a80b9a26752b0561
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