Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alexander McGown"'
Autor:
Matthew P. Shaw, Adrian Higginbottom, Alexander McGown, Lydia M. Castelli, Evlyn James, Guillaume M. Hautbergue, Pamela J. Shaw, Tennore M. Ramesh
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-16 (2018)
Abstract A hexanucleotide repeat expansion (HRE) within the chromosome 9 open reading frame 72 (C9orf72) gene is the most prevalent cause of amyotrophic lateral sclerosis/fronto-temporal dementia (ALS/FTD). Current evidence suggests HREs induce neuro
Externí odkaz:
https://doaj.org/article/869e058a2e124ab5881e47bd51e2976f
Unbiased metabolome screen leads to personalized medicine strategy for amyotrophic lateral sclerosis
Autor:
Sarah Boddy, Mahjabin Islam, Tobias Moll, Julian Kurz, David Burrows, Alexander McGown, Anushka Bhargava, Thomas H Julian, Calum Harvey, Jack NG Marshall, Benjamin PC Hall, Scott P Allen, Kevin P Kenna, Eleanor Sanderson, Sai Zhang, Tennore Ramesh, Michael P Snyder, Pamela J Shaw, Christopher McDermott, Johnathan Cooper-Knock
Publikováno v:
Boddy, S, Islam, M, Moll, T, Kurz, J, Burrows, D, Mcgown, A, Bhargava, A, Julian, T H, Harvey, C, Marshall, J N G, Hall, B P C, Allen, S P, Kenna, K P, Sanderson, E, Zhang, S, Ramesh, T, Snyder, M P, Shaw, P J, Mcdermott, C & Cooper-Knock, J 2022, ' Unbiased metabolome screen leads to personalized medicine strategy for amyotrophic lateral sclerosis ', Brain Communications, vol. 4, no. 2, fcac06 . https://doi.org/10.1093/braincomms/fcac069
Amyotrophic lateral sclerosis is a rapidly progressive neurodegenerative disease that affects 1/350 individuals in the United Kingdom. The cause of amyotrophic lateral sclerosis is unknown in the majority of cases. Two-sample Mendelian randomization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b6735b91e52fffdbdca321070879e9
https://research-information.bris.ac.uk/en/publications/37128d08-6565-4064-a3cb-1e7b01e3ad63
https://research-information.bris.ac.uk/en/publications/37128d08-6565-4064-a3cb-1e7b01e3ad63
Autor:
Alexander McGown, Adrian Higginbottom, Matthew P. Shaw, Guillaume M. Hautbergue, Evlyn James, Tennore Ramesh, Lydia M. Castelli, Pamela J. Shaw
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-16 (2018)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
A hexanucleotide repeat expansion (HRE) within the chromosome 9 open reading frame 72 (C9orf72) gene is the most prevalent cause of amyotrophic lateral sclerosis/fronto-temporal dementia (ALS/FTD). Current evidence suggests HREs induce neurodegenerat
Autor:
Milena De Felice, Basil Sharrack, Tennore Ramesh, David Burrows, Alexander McGown, Arshad Majid, Saurabh A. Jain
Publikováno v:
Multiple Sclerosis Journal. 25:306-324
Multiple sclerosis (MS) is a chronic, immune-mediated demyelinating disease of the central nervous system. Animal models of MS have been critical for elucidating MS pathological mechanisms and how they may be targeted for therapeutic intervention. He
Autor:
Karishma, Chhabria, Karen, Plant, Oliver, Bandmann, Robert N, Wilkinson, Chris, Martin, Elisabeth, Kugler, Paul A, Armitage, Paola Lm, Santoscoy, Vincent T, Cunliffe, Jan, Huisken, Alexander, McGown, Tennore, Ramesh, Tim Ja, Chico, Clare, Howarth
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism
Neurovascular coupling (through which local cerebral blood flow changes in response to neural activation are mediated) is impaired in many diseases including diabetes. Current preclinical rodent models of neurovascular coupling rely on invasive surge
Autor:
Matthew J. Stopford, Alexander McGown
Publikováno v:
Expert opinion on drug discovery. 13(11)
INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a rapid adult-onset neurodegenerative disorder characterised by the progressive loss of upper and lower motor neurons. Current treatment options are limited for ALS, with very modest effects on sur
Autor:
Tennore Ramesh, Alexander McGown, Huaxia Tong, Pamela J. Shaw, Christine E. Beattie, Niki Panagiotaki, Sufana Al Mashhadi, Jonathan R. McDearmid, Alison N. Lyon, Natasha Redhead
Publikováno v:
Annals of Neurology
Neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) are characterized by the presence of protein inclusions in the affected neurons. Emerging data indicate that protein misfolding may be of mechanistic importance in these disease
Publikováno v:
Molecular Neurodegeneration
Background Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease with death on average within 2–3 years of symptom onset. Mutations in superoxide dismutase 1 (SOD1) have been identified to cause ALS. Riluzole, the only neuroprot