Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Alexander Mazo"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Fibrosis, or excessive scarring, is characterized by the emergence of alpha-smooth muscle actin (αSMA)-expressing myofibroblasts and the excessive accumulation of fibrotic extracellular matrix (ECM). Currently, there is a lack of effective treatment
Externí odkaz:
https://doaj.org/article/446b8f3f01a14aa696c0a320bc41e34f
Autor:
Morgan D. Basta, Svetlana Petruk, Ross Summer, Joel Rosenbloom, Peter J. Wermuth, Edward Macarak, Alex V. Levin, Alexander Mazo, Janice L. Walker
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106570- (2023)
Summary: Cell reprogramming to a myofibroblast responsible for the pathological accumulation of extracellular matrix is fundamental to the onset of fibrosis. Here, we explored how condensed chromatin structure marked by H3K72me3 becomes modified to a
Externí odkaz:
https://doaj.org/article/ba372bd90ff342b6bee429d1eaefaafa
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 25, Iss 4, Pp 632-645 (2020)
In Drosophila melanogaster, in response to developmental transcription factors, and by repeated initiation of DNA replication of four chorion genes, ovarian follicle cells, form an onion skin-type structure at the replication origins. The DNA replica
Externí odkaz:
https://doaj.org/article/5afce524c932416d8a12c8ad4fa39f36
Publikováno v:
Epigenetics & Chromatin, Vol 10, Iss 1, Pp 1-17 (2017)
Abstract Background Maintenance of cell fate determination requires the Polycomb group for repression; the trithorax group for gene activation; and the enhancer of trithorax and Polycomb (ETP) group for both repression and activation. Additional sex
Externí odkaz:
https://doaj.org/article/464df4cbef0e459c8049cc716c2a2147
Autor:
Svetlana Petruk, Samanta A. Mariani, Marco De Dominici, Patrizia Porazzi, Valentina Minieri, Jingli Cai, Lorraine Iacovitti, Neal Flomenberg, Bruno Calabretta, Alexander Mazo
Publikováno v:
Cell Reports, Vol 19, Iss 2, Pp 295-306 (2017)
Summary: The role of chromatin structure in lineage commitment of multipotent hematopoietic progenitors (HPCs) is presently unclear. We show here that CD34+ HPCs possess a post-replicative chromatin globally devoid of the repressive histone mark H3K2
Externí odkaz:
https://doaj.org/article/5bd388368332412081472e38aff5b32a
Autor:
Jill Bargonetti, Alexander Mazo, Olufunmilayo I. Olopade, Galina F. Khramtsova, Thomas Reiner, Patrick L. Donabedian, Alla Polotskaia, Viola Ellison, Jorge Canar, George K. Annor, Devon Lundine, Gu Xiao
S3 Mutant p53/PARP and Mutant p53/Edu Complexes in MDA-MB-468 and PANC-1 Cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eac70e9b64f0f76e80d42894c091f42
https://doi.org/10.1158/0008-5472.22425127.v1
https://doi.org/10.1158/0008-5472.22425127.v1
Autor:
Bruno Calabretta, Alexander Mazo, Christine M. Eischen, Paolo Fortina, Adam Ertel, Pierluigi Porcu, Neil Palmisiano, Eli Canaani, Alessandro Gardini, Marco Trizzino, Alexis Grande, Sandra Deliard, Elisa Barbieri, Valentina Minieri, Gaurav Kumar, Saul Kushinsky, Matthew V. Puccetti, David Deming, Marco De Dominici, Luca Pagliaroli, Svetlana Petruk, Patrizia Porazzi
Despite treatment with intensive chemotherapy, acute myelogenous leukemia (AML) remains an aggressive malignancy with a dismal outcome in most patients. We found that AML cells exhibit an unusually rapid accumulation of the repressive histone mark H3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec590e126a2276bbb1c315321caff927
https://doi.org/10.1158/0008-5472.c.6513811.v1
https://doi.org/10.1158/0008-5472.c.6513811.v1
Autor:
Jill Bargonetti, Alexander Mazo, Olufunmilayo I. Olopade, Galina F. Khramtsova, Thomas Reiner, Patrick L. Donabedian, Alla Polotskaia, Viola Ellison, Jorge Canar, George K. Annor, Devon Lundine, Gu Xiao
S2 Mutant p53 R273H and Flag-R248W associate with replicating DNA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aeed6b59b649882045e2d32d668ad6b
https://doi.org/10.1158/0008-5472.22425130.v1
https://doi.org/10.1158/0008-5472.22425130.v1
Autor:
Bruno Calabretta, Alexander Mazo, Christine M. Eischen, Paolo Fortina, Adam Ertel, Pierluigi Porcu, Neil Palmisiano, Eli Canaani, Alessandro Gardini, Marco Trizzino, Alexis Grande, Sandra Deliard, Elisa Barbieri, Valentina Minieri, Gaurav Kumar, Saul Kushinsky, Matthew V. Puccetti, David Deming, Marco De Dominici, Luca Pagliaroli, Svetlana Petruk, Patrizia Porazzi
Supplemental Table IIList of Primers used for Real Time PCR experiments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb664a2e7f238dc807c7a8e29de2185f
https://doi.org/10.1158/0008-5472.22431139.v1
https://doi.org/10.1158/0008-5472.22431139.v1
Autor:
Jill Bargonetti, Alexander Mazo, Olufunmilayo I. Olopade, Galina F. Khramtsova, Thomas Reiner, Patrick L. Donabedian, Alla Polotskaia, Viola Ellison, Jorge Canar, George K. Annor, Devon Lundine, Gu Xiao
Over 80% of triple-negative breast cancers (TNBC) express mutant p53 (mtp53) and some contain oncogenic gain-of-function (GOF) p53. We previously reported that GOF mtp53 R273H upregulates the chromatin association of mini chromosome maintenance (MCM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af203c4bf97f75ab84bf2c577e20a0bd
https://doi.org/10.1158/0008-5472.c.6511948.v1
https://doi.org/10.1158/0008-5472.c.6511948.v1