Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alexander Maxan"'
Autor:
Shireen Salem, Mitchell D. Kilgore, Mehwish Anwer, Alexander Maxan, Dan Child, Thomas D. Bird, C. Dirk Keene, Francesca Cicchetti, Caitlin Latimer
Publikováno v:
Neurobiology of Disease, Vol 198, Iss , Pp 106542- (2024)
A number of post-mortem studies conducted in transplanted Huntington’s disease (HD) patients from various trials have reported the presence of pathological and misfolded proteins, in particular mutant huntingtin (mHtt) and phosphorylated tau neurop
Externí odkaz:
https://doaj.org/article/37142461fe974d63affbe2c99d51888b
Autor:
Philippe Gosset, Alexander Maxan, Melanie Alpaugh, Ludivine Breger, Benjamin Dehay, Zhu Tao, Zhang Ling, Chuan Qin, Giulia Cisbani, Nadia Fortin, Jean-Paul G. Vonsattel, Steve Lacroix, Abid Oueslati, Erwan Bezard, Francesca Cicchetti
Publikováno v:
Neurobiology of Disease, Vol 141, Iss , Pp 104941- (2020)
In recent years, substantial evidence has emerged to suggest that spreading of pathological proteins contributes to disease pathology in numerous neurodegenerative disorders. Work from our laboratory and others have shown that, despite its strictly g
Externí odkaz:
https://doaj.org/article/ce39361aa4fd446ead26ea49a70374d5
Autor:
Stefan Bartl, Abid Oueslati, Amber L. Southwell, Alberto Siddu, Michela Parth, Linda Suzanne David, Alexander Maxan, Nina Salhat, Markus Burkert, Andreas Mairhofer, Theresa Friedrich, Halyna Pankevych, Katja Balazs, Guenther Staffler, Michael R. Hayden, Francesca Cicchetti, Oskar W. Smrzka
Publikováno v:
Neurobiology of Disease, Vol 141, Iss , Pp 104943- (2020)
Huntington's disease (HD) is caused by a highly polymorphic CAG trinucleotide expansion in the gene encoding for the huntingtin protein (HTT). The resulting mutant huntingtin protein (mutHTT) is ubiquitously expressed but also exhibits the ability to
Externí odkaz:
https://doaj.org/article/7a2a9cc730a442b79298549f98f442c9
Autor:
Alexander Maxan, Giacomo Sciacca, Melanie Alpaugh, Zhu Tao, Ludivine Breger, Benjamin Dehay, Zhang Ling, Qin Chuan, Giulia Cisbani, Maria Masnata, Shireen Salem, Steve Lacroix, Abid Oueslati, Erwan Bezard, Francesca Cicchetti
Publikováno v:
Neurobiology of Disease, Vol 141, Iss , Pp 104951- (2020)
In order to model various aspects of Huntington's disease (HD) pathology, in particular protein spread, we administered adeno-associated virus (AAV) expressing green fluorescent protein (GFP) or GFP coupled to HTT-Exon1 (19Q or 103Q) to the central n
Externí odkaz:
https://doaj.org/article/8299fe38e0f742efb1c5fe681f096cc6
Autor:
Alexander Maxan, Francesca Cicchetti
Publikováno v:
Journal of Experimental Neuroscience, Vol 12 (2018)
There is compelling evidence that a number of neurodegenerative diseases share common pathogenic mechanisms. Better understanding these mechanisms will allow us to develop new therapeutic strategies. This commentary follows up on our recent findings
Externí odkaz:
https://doaj.org/article/67c087a4b1b84626be83d6acd4e06109
Autor:
Steve Lacroix, Benjamin Dehay, Chuan Qin, Giulia Cisbani, Ludivine S. Breger, Abid Oueslati, Zhang Ling, Melanie Alpaugh, Alexander Maxan, Zhu Tao, Jean-Paul Vonsattel, Philippe Gosset, Erwan Bezard, Nadia Fortin, Francesca Cicchetti
Publikováno v:
Neurobiology of Disease
Neurobiology of Disease, 2020, 141, pp.104941. ⟨10.1016/j.nbd.2020.104941⟩
Neurobiology of Disease, Elsevier, 2020, 141, pp.104941. ⟨10.1016/j.nbd.2020.104941⟩
Neurobiology of Disease, Vol 141, Iss, Pp 104941-(2020)
Neurobiology of Disease, 2020, 141, pp.104941. ⟨10.1016/j.nbd.2020.104941⟩
Neurobiology of Disease, Elsevier, 2020, 141, pp.104941. ⟨10.1016/j.nbd.2020.104941⟩
Neurobiology of Disease, Vol 141, Iss, Pp 104941-(2020)
International audience; In recent years, substantial evidence has emerged to suggest that spreading of pathological proteins contributes to disease pathology in numerous neurodegenerative disorders. Work from our laboratory and others have shown that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935b78a6b1e1620f4dff1bcc0b16e475
https://www.hal.inserm.fr/inserm-02613508
https://www.hal.inserm.fr/inserm-02613508
Autor:
Abid Oueslati, Zhang Ling, Ludivine S. Breger, Melanie Alpaugh, Benjamin Dehay, Zhu Tao, Francesca Cicchetti, Giacomo Sciacca, Steve Lacroix, Shireen Salem, Erwan Bezard, Alexander Maxan, Giulia Cisbani, Qin Chuan, Maria Masnata
Publikováno v:
Neurobiology of Disease
Neurobiology of Disease, Elsevier, 2020, pp.104951. ⟨10.1016/j.nbd.2020.104951⟩
Neurobiology of Disease, Vol 141, Iss, Pp 104951-(2020)
Neurobiology of Disease, 2020, pp.104951. ⟨10.1016/j.nbd.2020.104951⟩
Neurobiology of Disease, Elsevier, 2020, pp.104951. ⟨10.1016/j.nbd.2020.104951⟩
Neurobiology of Disease, Vol 141, Iss, Pp 104951-(2020)
Neurobiology of Disease, 2020, pp.104951. ⟨10.1016/j.nbd.2020.104951⟩
International audience; In order to model various aspects of Huntington's disease (HD) pathology, in particular protein spread, we administered adeno-associated virus (AAV) expressing green fluorescent protein (GFP) or GFP coupled to HTT-Exon1 (19Q o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e7873a8ea7fe2ecf66f7fff94bed95
https://www.hal.inserm.fr/inserm-02615641
https://www.hal.inserm.fr/inserm-02615641
Autor:
Julie C. Savage, Emma Smith, Roger A. Barker, Alexander Maxan, Nicola Pavese, Anne Elizabeth Rosser, Peter V Gould, Paola Piccini, Sarah L Mason, Stephen B. Dunnett, Timothy Harrower, Colin Watts, Yen F. Tai, Aileen K Ho, Martine Saint-Pierre, Marie-Ève Tremblay, Francesca Cicchetti
Publikováno v:
Annals of Neurology. 84:950-956
For patients with incurable neurodegenerative disorders such as Huntington's (HD) and Parkinson's disease, cell transplantation has been explored as a potential treatment option. Here, we present the first clinicopathological study of a patient with
Autor:
Halyna Pankevych, Stefan Bartl, Amber L. Southwell, Michela Parth, Theresa Friedrich, Alexander Maxan, Michael R. Hayden, Francesca Cicchetti, Guenther Staffler, Andreas Mairhofer, Alberto Siddu, Nina Salhat, Abid Oueslati, Katja Balazs, Markus Burkert, Oskar W. Smrzka, Linda Suzanne David
Publikováno v:
Neurobiology of Disease, Vol 141, Iss, Pp 104943-(2020)
Huntington's disease (HD) is caused by a highly polymorphic CAG trinucleotide expansion in the gene encoding for the huntingtin protein (HTT). The resulting mutant huntingtin protein (mutHTT) is ubiquitously expressed but also exhibits the ability to
Autor:
Jordan Nantais, Nizam Farah, Tristan C. Dumbarton, Christian Lehmann, Juan Zhou, Nivin Sharawy, Alexander Maxan
Publikováno v:
Clinical Hemorheology and Microcirculation. 67:15-24
BACKGROUND Tetrahydrobiopterin (BH4), an endogenous nucleic acid derivative, acts as an important cofactor for several enzymes found within the vascular endothelium, which is deranged in sepsis. OBJECTIVE We hypothesized that BH4 would improve capill