Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Alexander M. Simon"'
Autor:
Samuel Corless, Noor Pratap-Singh, Nezha S. Benabdallah, Jasmin Böhm, Alexander M. Simon, Vojtěch Dolejš, Simon Anders, Ana Banito, Sylvia Erhardt
Centromeres are the position on each chromosome that orchestrates the accurate partitioning of the genome during cell division. Centromere-dependent cell-cycle checkpoints are maintained by cancer cells to prevent catastrophic chromosome segregation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::462eea447520c04ad6b0b85d6b9451d1
https://doi.org/10.1101/2023.03.15.532673
https://doi.org/10.1101/2023.03.15.532673
Autor:
Philip D. King, Michael J. Davis, R. Sathish Srinivasan, Jorge A. Castorena-Gonzalez, Alexander M. Simon
Publikováno v:
J Physiol
Key points Lymphatic valve defects are one of the major causes of lymph transport dysfunction; however, there are no accessible methods for quantitatively assessing valve function. This report describes a novel technique for quantifying lymphatic val
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e130df3ad6f906c842b2b1cc0ef31b9
https://doi.org/10.1113/jp279472
https://doi.org/10.1113/jp279472
Autor:
Saskia L. Höcker, Izlem Su Akan, Alexander M. Simon, Kerem Yildirim, Lili A. Kenéz, Ingrid Lohmann, Sylvia Erhardt
Publikováno v:
bioRxiv
In many metazoans, centromeres are embedded in large blocks of highly repetitive (peri-) centromeric heterochromatin from which non-coding RNAs emanate that have been assigned diverse functions in different species. However, little is known about the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a8f938bd941deb6aa308459f1118ec
https://doi.org/10.1101/2022.02.05.479222
https://doi.org/10.1101/2022.02.05.479222
Autor:
Jorge A. Castorena-Gonzalez, Roger de la Torre, Luis A. Martinez-Lemus, Scott D. Zawieja, Cor de Wit, R. Sathish Srinivasan, Alexander M. Simon, Michael J. Davis, Min Li, Grant W. Hennig
Publikováno v:
Circulation Research. 123:964-985
Rationale:Mutations inGJC2andGJA1, encoding Cxs (connexins) 47 and 43, respectively, are linked to lymphedema, but the underlying mechanisms are unknown. Because efficient lymph transport relies on the coordinated contractions of lymphatic muscle cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dd9d0dc7e94868cbe533a161efe4f1c
https://doi.org/10.1161/circresaha.117.312576
https://doi.org/10.1161/circresaha.117.312576
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 304:H816-H827
Recently, we reported that recovery of tissue perfusion in the ischemic hindlimb was reduced, inflammatory response increased, and survival of distal limb tissue compromised in connexin 40 (Cx40)-deficient (Cx40−/−) mice. Here we evaluate whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3233fb9fa19b0ceb4bdd00fd5af8d39c
https://doi.org/10.1152/ajpheart.00719.2012
https://doi.org/10.1152/ajpheart.00719.2012
Publikováno v:
Developmental Biology. 373:338-348
Venous valves play a crucial role in blood circulation, promoting the one-way movement of blood from superficial and deep veins towards the heart. By preventing retrograde flow, venous valves spare capillaries and venules from being subjected to dama
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c17a15c7642c7afb77f489f51cbb45
https://doi.org/10.1016/j.ydbio.2012.10.032
https://doi.org/10.1016/j.ydbio.2012.10.032
Lymphatic valves (LVs) are cusped luminal structures that permit the movement of lymph in only one direction and are therefore critical for proper lymphatic vessel function. Congenital valve aplasia or agenesis can, in some cases, be a direct cause o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eccedb249f62344960dbf8dd5aec78a
https://europepmc.org/articles/PMC5217530/
https://europepmc.org/articles/PMC5217530/
Autor:
Martyn P. Mahaut-Smith, Parvathy Sasikumar, Jonathan M. Gibbins, Stephanie J. Munger, Katherine L. Tucker, Tanya Sage, Marfoua S. Ali, Ernesto Oviedo-Orta, Alexander P. Bye, Alexander M. Simon, Sakthivel Vaiyapuri, Leonardo A. Moraes, Sarah Jones, William J. Kaiser, Joy R. Wright, Chris Stain, Chris I. Jones
Publikováno v:
Circulation. 125:2479-2491
Background— Connexins are a widespread family of membrane proteins that assemble into hexameric hemichannels, also known as connexons. Connexons regulate membrane permeability in individual cells or couple between adjacent cells to form gap junctio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be72a1a511e4afa20ce8758c1726b571
https://doi.org/10.1161/circulationaha.112.101246
https://doi.org/10.1161/circulationaha.112.101246
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 301:H1872-H1881
The unique contributions of connexin (Cx)37 and Cx40, gap junction-forming proteins that are coexpressed in vascular endothelium, to the recovery of tissues from ischemic injury are unknown. We recently reported that Cx37-deficient (Cx37−/−) anim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b995c2e2b506a841b7e34f95e2bbf7ef
https://doi.org/10.1152/ajpheart.00683.2011
https://doi.org/10.1152/ajpheart.00683.2011
Publikováno v:
Journal of Vascular Research. 49:2-12
Background/Aims: Ischemia induced by large-vessel obstruction or vascular injury induces a complex cascade of vasodilatory, remodeling and inflammatory pathways; coordination of these processes by vascular endothelium is likely to involve endothelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ada83822e42e786ed0a311b9cc13604
https://doi.org/10.1159/000329616
https://doi.org/10.1159/000329616