Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Alexander M. Porte"'
Autor:
Chakrapani Subramanyam, Alison H. Varghese, Christopher J. O’Donnell, Michael J. Shapiro, Suman Shanker, Andreas Maderna, Cynthia Song, Beth C. Vetelino, My-Hanh Lam, Matthew David Doroski, Frank Loganzo, Hud Lawrence Risley, Kathleen A. Farley, Zecheng Chen, Melissa Wagenaar, Carolyn A. Leverett, Jayvardhan Pandit, Alexander M. Porte, Kevin D. Parris, Sylvia Musto, Sai Chetan K. Sukuru
Publikováno v:
Journal of medicinal chemistry. 57(24)
Auristatins, synthetic analogues of the antineoplastic natural product Dolastatin 10, are ultrapotent cytotoxic microtubule inhibitors that are clinically used as payloads in antibody-drug conjugates (ADCs). The design and synthesis of several new au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02da5b4b0c1a923d6ea1fa2b8f91094e
https://pubmed.ncbi.nlm.nih.gov/25431858
https://pubmed.ncbi.nlm.nih.gov/25431858
Publikováno v:
Tetrahedron. 57:5027-5038
A new class of optically active, monodentate, C3-symmetric ligands for asymmetric catalysis, 1–3, were prepared via routes involving asymmetric reduction of aryl ketones ( Scheme 1 , Scheme 2 , Scheme 3 ) Download : Download high-res image (151KB)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5fcb6e56c96d9b36794d8d75f6084be
https://doi.org/10.1016/s0040-4020(01)00346-5
https://doi.org/10.1016/s0040-4020(01)00346-5
Publikováno v:
Journal of the American Chemical Society. 120:9180-9187
This paper uses the phosphine oxazoline ligands 1 and an allylation transformation (reaction 1) to illustrate the value of divergent ligand syntheses and high-throughput screening in catalyst discovery and optimization. Thus, a diverse set of ligands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce37ee73f3710418e2bfb022ec8e768b
https://doi.org/10.1021/ja981217k
https://doi.org/10.1021/ja981217k
Autor:
Kevin Burgess, Alexander M. Porte
Publikováno v:
Tetrahedron: Asymmetry. 9:2465-2469
A library of novel phosphine oxazoline ligands 2 was tested in the asymmetric allylation of 4-acyloxy-2-pentenes 1 . High throughput screening techniques were employed to accelerate this process. The data accumulated allowed the extent of asymmetric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cfb36514a56cc56be7b4809cbc5f41e
https://doi.org/10.1016/s0957-4166(98)00230-4
https://doi.org/10.1016/s0957-4166(98)00230-4
Autor:
Kevin Burgess, Alexander M. Porte
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afebe835e5ccd6027ee20498f778fd38
https://doi.org/10.1002/chin.199443196
https://doi.org/10.1002/chin.199443196
Autor:
Alexander M. Porte, Kevin Burgess
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a460bfe6ea98a9841fab0ceff2202e57
https://doi.org/10.1002/chin.199826342
https://doi.org/10.1002/chin.199826342
Autor:
Alexander M. Porte, Kevin Burgess
Publikováno v:
ChemInform. 29
A library of novel phosphine oxazoline ligands 2 was tested in the asymmetric allylation of 4-acyloxy-2-pentenes 1 . High throughput screening techniques were employed to accelerate this process. The data accumulated allowed the extent of asymmetric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f403fdff2f10d2ccfa93fccd0d960966
https://doi.org/10.1002/chin.199849042
https://doi.org/10.1002/chin.199849042
Publikováno v:
ChemInform. 30
This paper uses the phosphine oxazoline ligands 1 and an allylation transformation (reaction 1) to illustrate the value of divergent ligand syntheses and high-throughput screening in catalyst discovery and optimization. Thus, a diverse set of ligands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86000a5dd08a550b2d4a4def2934d7c0
https://doi.org/10.1002/chin.199903135
https://doi.org/10.1002/chin.199903135
Publikováno v:
ChemInform. 30
Ligand sets 1 and 2 were prepared and examined for evidence of C3-symmetric propeller-shaped conformations in solution, and for their ability to induce enantioselectivity in an allylation reaction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d17b906b73a2a9b640f375fa19602206
https://doi.org/10.1002/chin.199902114
https://doi.org/10.1002/chin.199902114
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e50ef0943a6f9d565e6518f308ea072b
https://doi.org/10.1002/chin.199851231
https://doi.org/10.1002/chin.199851231