Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Alexander M. Lodge"'
Autor:
Joseph J. Topczewski, Daniel M. Quinn, Jason A. Morrill, Nilanthi Yasapala, Alexander M. Lodge
Publikováno v:
Journal of Molecular Graphics and Modelling. 62:181-189
Among the most toxic substances known are the organophosphorus (OP) compounds used as pesticides and chemical warfare agents. Owing to their high toxicity there is a number of efforts underway to develop effective therapies for OP agent exposure. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec79f986ffa7037e0cb20095a1e6d32e
https://doi.org/10.1016/j.jmgm.2015.09.016
https://doi.org/10.1016/j.jmgm.2015.09.016
Publikováno v:
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules, Vol 22, Iss 9, p 1464 (2017)
Molecules, Vol 22, Iss 9, p 1464 (2017)
Organophosphorus agents are potent inhibitors of acetylcholinesterase. Inhibition involves successive chemical events. The first is phosphylation of the active site serine to produce a neutral adduct, which is a close structural analog of the acylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a912e5e9aa465c307c7accba73c748a
http://europepmc.org/articles/PMC6151809
http://europepmc.org/articles/PMC6151809
Autor:
Pedrom M. Keshavarzi, Joseph J. Topczewski, Sumana N. Yasapala, Maurice K. Payne, Alexander M. Lodge, Daniel M. Quinn
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5786-5789
The irreversible inhibition of acetylcholinesterase (AChE) by organophosphorous chemical warfare agents necessitates that antidotes be administered for effective treatment. Currently no antidote is known that resurrects the phosphyl-AChE complex once
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14cbd835e3f6a7361c583417477d1474
https://doi.org/10.1016/j.bmcl.2013.09.008
https://doi.org/10.1016/j.bmcl.2013.09.008
Publikováno v:
Environmental Chemistry. 4:260
Environmental context. Iron metal is being considered as a material to be used for the treatment of groundwater contaminated with toxic metals and organics. Although time-dependant information is available, predicting the long-term behaviour of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57b5139b9f0bbc82a2afd9cbebe5f7d8
https://doi.org/10.1071/en07004
https://doi.org/10.1071/en07004