Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Alexander M. Kollikowski"'
Autor:
Alexander M. Kollikowski, Mirko Pham, Alexander G. März, Jörn Feick, Marius L. Vogt, Yanyan Xiong, Marc Strinitz, Christoph Vollmuth, Fabian Essig, Hermann Neugebauer, Karl Georg Haeusler, Christian Hametner, Lena Zimmermann, Guido Stoll, Michael K. Schuhmann
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105095- (2024)
Summary: Background: Matrix metalloproteinases (MMPs) are implied in blood–brain barrier degradation and haemorrhagic transformation following ischaemic stroke, but their local relevance in the hyperacute disease phase is unknown. We aimed to exami
Externí odkaz:
https://doaj.org/article/6cbc00f3ba454381a890f3ccf41b2636
Autor:
Lorenzo Barba, Christoph Vollmuth, Samir Abu-Rumeileh, Steffen Halbgebauer, Patrick Oeckl, Petra Steinacker, Alexander M. Kollikowski, Cara Schultz, Judith Wolf, Mirko Pham, Michael K. Schuhmann, Peter U. Heuschmann, Karl Georg Haeusler, Guido Stoll, Hermann Neugebauer, Markus Otto
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract We aimed to assess the prognostic value of serum β-synuclein (β-syn), neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in patients with moderate-to-severe acute ischemic stroke. We measured β-syn, GFAP and NfL in
Externí odkaz:
https://doaj.org/article/e4b568f07c824155bc3dfb236de0636a
Autor:
Michael K. Schuhmann, Michael Bieber, Maximilian Franke, Alexander M. Kollikowski, David Stegner, Katrin G. Heinze, Bernhard Nieswandt, Mirko Pham, Guido Stoll
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-9 (2021)
Abstract Background In acute ischemic stroke, cessation of blood flow causes immediate tissue necrosis within the center of the ischemic brain region accompanied by functional failure in the surrounding brain tissue designated the penumbra. The penum
Externí odkaz:
https://doaj.org/article/841feb61251540548bf969199a467fbc
Autor:
Axel Haarmann, Christoph Vollmuth, Alexander M. Kollikowski, Peter U. Heuschmann, Mirko Pham, Guido Stoll, Hermann Neugebauer, Michael K. Schuhmann
Publikováno v:
Cells, Vol 12, Iss 2, p 288 (2023)
Now that mechanical thrombectomy has substantially improved outcomes after large-vessel occlusion stroke in up to every second patient, futile reperfusion wherein successful recanalization is not followed by a favorable outcome is moving into focus.
Externí odkaz:
https://doaj.org/article/7e54e058b2fd4d8a904915e45c4d6dc7
Autor:
Michael K. Schuhmann, Alexander M. Kollikowski, Alexander G. März, Michael Bieber, Mirko Pham, Guido Stoll
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 15, Iss , Pp 100270- (2021)
Objective: Immune responses are an integral part of the complex reactions to acute cerebral ischemia and contribute to infarct expansion and tissue remodeling. Among damage-associated molecular patterns (DAMPs) the high-mobility group box 1 protein (
Externí odkaz:
https://doaj.org/article/922a14da55d343368f61df2982fe234e
Autor:
Fabian Essig, Lilith Babilon, Christoph Vollmuth, Alexander M. Kollikowski, Mirko Pham, László Solymosi, Karl Georg Haeusler, Peter Kraft, Guido Stoll, Michael K. Schuhmann
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 11276 (2021)
High-mobility group box 1 protein (HMGB1) is a damage-associated molecular pattern (DAMP) involved in neutrophil extracellular trap (NET) formation and thrombosis. NETs are regularly found in cerebral thromboemboli. We here analyzed associated HMGB1
Externí odkaz:
https://doaj.org/article/15955f85efc542a6b33246db9767ae34
Autor:
Marc Strinitz, Mirko Pham, Alexander G. März, Jörn Feick, Franziska Weidner, Marius L. Vogt, Fabian Essig, Hermann Neugebauer, Guido Stoll, Michael K. Schuhmann, Alexander M. Kollikowski
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9161 (2021)
It remains unclear if principal components of the local cerebral stroke immune response can be reliably and reproducibly observed in patients with acute large-vessel-occlusion (LVO) stroke. We prospectively studied a large independent cohort of n = 3
Externí odkaz:
https://doaj.org/article/bcf9613cdd464b83b87f595a7507c022
Autor:
Fabian Essig, Alexander M. Kollikowski, Mirko Pham, László Solymosi, Guido Stoll, Karl Georg Haeusler, Peter Kraft, Michael K. Schuhmann
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7387 (2020)
Ischemic stroke caused by thromboembolic occlusion of large cerebral arteries, such as the internal carotid (ICA) and/or the middle cerebral artery (MCA), is treated by mechanical thrombectomy (MT). MT allows salvage of the vessel-occluding thrombemb
Externí odkaz:
https://doaj.org/article/628ae448816b40458e20599dc31afbb3
Autor:
Michael K. Schuhmann, Peter Kraft, Michael Bieber, Alexander M. Kollikowski, Harald Schulze, Bernhard Nieswandt, Mirko Pham, David Stegner, Guido Stoll
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 8, p 2019 (2019)
Platelet collagen interactions at sites of vascular injuries predominantly involve glycoprotein VI (GPVI) and the integrin α2β1. Both proteins are primarily expressed on platelets and megakaryocytes whereas GPVI expression is also shown on endothel
Externí odkaz:
https://doaj.org/article/392fef892d2b4332bdba8842f11ef1fc
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 42:1561-1567
In stroke patients, local sampling of pial blood within the occluded vasculature before recanalization by mechanical thrombectomy emerged as powerful tool enabling insights into ultra-early stroke pathophysiology. Thereby, a strong intravascular infl