Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Alexander M. Kloosterman"'
Autor:
Sanne Westhoff, Alexander M. Kloosterman, Stephan F. A. van Hoesel, Gilles P. van Wezel, Daniel E. Rozen
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
Bacteria secrete antibiotics to inhibit their competitors, but the presence of competitors can determine whether these toxins are produced. Here, we study the role of the competitive and resource environment on antibiotic production in Streptomyces
Externí odkaz:
https://doaj.org/article/39b94ec39ce84a96adceac6ab70eb252
Autor:
Alexander M. Kloosterman, Kyle E. Shelton, Gilles P. van Wezel, Marnix H. Medema, Douglas A. Mitchell
Publikováno v:
mSystems, Vol 5, Iss 5 (2020)
ABSTRACT Many ribosomally synthesized and posttranslationally modified peptide classes (RiPPs) are reliant on a domain called the RiPP recognition element (RRE). The RRE binds specifically to a precursor peptide and directs the posttranslational modi
Externí odkaz:
https://doaj.org/article/ce25faef136a41aa9e3347852a036493
Autor:
Gilles P. van Wezel, Tilmann Weber, Simon Shaw, Kai Blin, Alexander M. Kloosterman, Zach Charlop-Powers, Marnix H. Medema
Publikováno v:
Nucleic Acids Research, 49(W1), W29-W35. Oxford University Press
Nucleic acids research 49 (2021) W1
Nucleic Acids Research
Nucleic acids research, 49(W1), W29-W35
Blin, K, Shaw, S, Kloosterman, A M, Charlop-Powers, Z, van Wezel, G P, Medema, M H & Weber, T 2021, ' antiSMASH 6.0: improving cluster detection and comparison capabilities ', Nucleic Acids Research . https://doi.org/10.1093/nar/gkab335
Nucleic Acids Research. Oxford University Press ({OUP})
Nucleic acids research 49 (2021) W1
Nucleic Acids Research
Nucleic acids research, 49(W1), W29-W35
Blin, K, Shaw, S, Kloosterman, A M, Charlop-Powers, Z, van Wezel, G P, Medema, M H & Weber, T 2021, ' antiSMASH 6.0: improving cluster detection and comparison capabilities ', Nucleic Acids Research . https://doi.org/10.1093/nar/gkab335
Nucleic Acids Research. Oxford University Press ({OUP})
Many microorganisms produce natural products that form the basis of antimicrobials, antivirals, and other drugs. Genome mining is routinely used to complement screening-based workflows to discover novel natural products. Since 2011, the "antibiotics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce371ac1e602b848ec2450324fff8446
https://pure.knaw.nl/portal/en/publications/911e6a05-f3aa-485c-87a1-bee812a72ec6
https://pure.knaw.nl/portal/en/publications/911e6a05-f3aa-485c-87a1-bee812a72ec6
Autor:
Alexander M. Kloosterman, Sanne Westhoff, Stephan F. A. van Hoesel, Daniel E. Rozen, Gilles P. van Wezel
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
mBio, 12(1):e02729-20, 1-13. American Society for Microbiology
mBio, 12, e02729
mBio, 12(1):e02729-20, 1-13. American Society for Microbiology
mBio, 12, e02729
One of the most important ways that bacteria compete for resources and space is by producing antibiotics that inhibit competitors. Because antibiotic production is costly, the biosynthetic gene clusters coordinating their synthesis are under strict r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d4bcb3454c4a36c1855a97f595aec2
https://doi.org/10.1128/mbio.02729-20
https://doi.org/10.1128/mbio.02729-20
Publikováno v:
Current Opinion in Biotechnology, 69, 60-67. Elsevier BV
Current Opinion in Biotechnology, 69, 60-67
Current Opinion in Biotechnology 69 (2021)
Current Opinion in Biotechnology
Current Opinion in Biotechnology, 69, 60-67
Current Opinion in Biotechnology 69 (2021)
Current Opinion in Biotechnology
Ribosomally synthesized and post-translationally modified peptides (RiPPs) form a highly diverse class of natural products, with various biotechnologically and clinically relevant activities. A recent increase in discoveries of novel RiPP classes sug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36970252fa14bf1affe89627d3cef305
http://hdl.handle.net/1887/3204145
http://hdl.handle.net/1887/3204145
Autor:
Peter Cimermancic, Michael A. Fischbach, Chao Du, Marnix H. Medema, Gilles P. van Wezel, Michalis Hadjithomas, Alexander M. Kloosterman, Mohamed S. Donia, S. S. Elsayed
Most clinical drugs are based on microbial natural products, with compound classes including polyketides (PKS), non-ribosomal peptides (NRPS), fluoroquinones and ribosomally synthesized and post-translationally modified peptides (RiPPs). While varian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea865bb3c057fb2f71d1455687b3b449
https://doi.org/10.1101/2020.05.19.104752
https://doi.org/10.1101/2020.05.19.104752
Autor:
Daniel E. Rozen, Gilles P. van Wezel, Stephan F. A. van Hoesel, Sanne Westhoff, Alexander M. Kloosterman
One of the most important ways that bacteria compete for resources and space is by producing antibiotics that inhibit competitors. Because antibiotic production is costly, the biosynthetic gene clusters coordinating their synthesis are under strict r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852551b096135ea3459c8306d9e4c2fa
Autor:
Peter Cimermancic, Michael A. Fischbach, Alexander M. Kloosterman, Somayah S. Elsayed, Gilles P. van Wezel, Marnix H. Medema, Michalis Hadjithomas, Mohamed S. Donia, Chao Du
Publikováno v:
PloS Biology, 18
PLoS Biology, Vol 18, Iss 12, p e3001026 (2020)
PLoS Biology
PloS Biology 18 (2020)
PLoS Biology, 18(12), e3001026
PLoS Biology, Vol 18, Iss 12, p e3001026 (2020)
PLoS Biology
PloS Biology 18 (2020)
PLoS Biology, 18(12), e3001026
Microbial natural products constitute a wide variety of chemical compounds, many which can have antibiotic, antiviral, or anticancer properties that make them interesting for clinical purposes. Natural product classes include polyketides (PKs), nonri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412e65b2c866ff42f148c76879df05d5
https://research.wur.nl/en/publications/expansion-of-ripp-biosynthetic-space-through-integration-of-pan-g
https://research.wur.nl/en/publications/expansion-of-ripp-biosynthetic-space-through-integration-of-pan-g
Autor:
Alexander M. Kloosterman, Guilles P. Van Wezel, Imen Nouioui, José Mariano Igual, Michael Goodfellow, Joost Willemse, Lizah T. van der Aart
Publikováno v:
International Journal of Systematic and Evolutionary Microbiology, 69(4), 899-908
Digital.CSIC. Repositorio Institucional del CSIC
instname
International Journal of Systematic and Evolutionary Microbiology
International Journal of Systematic and Evolutionary Microbiology, 69(4), 899-908. Society for General Microbiology
Digital.CSIC. Repositorio Institucional del CSIC
instname
International Journal of Systematic and Evolutionary Microbiology
International Journal of Systematic and Evolutionary Microbiology, 69(4), 899-908. Society for General Microbiology
29 páginas, 3 tablas, 4 figuras
A polyphasic study was designed to establish the taxonomic status of a Streptomyces strain isolated from soil from the QinLing Mountains, Shaanxi Province, China, and found to be the source of known and new speci
A polyphasic study was designed to establish the taxonomic status of a Streptomyces strain isolated from soil from the QinLing Mountains, Shaanxi Province, China, and found to be the source of known and new speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28956cd0ea62ca7a866ee74bf2e12b27
http://hdl.handle.net/1887/81954
http://hdl.handle.net/1887/81954
Autor:
Alexander M. Kloosterman, I Nouinoui, JM Ingual, G Wezel van, Michael Goodfellow, Joost Willemse, L der Aart van
A novel verticillate strain of streptomycetes,Streptomycesstrain MBT76T, was isolated from the QinLing mountains, which harbours more than 40 biosynthetic gene clusters for natural products. Here we present full taxonomic classification of strain MBT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1fc29051b2451ac4bfa5ec30b1cd97
https://doi.org/10.1101/310888
https://doi.org/10.1101/310888