Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Alexander M. Horspool"'
Autor:
Alexander M. Horspool, Emel Sen-Kilic, Aaron C. Malkowski, Scott L. Breslow, Margalida Mateu-Borras, Matthew S. Hudson, Mason A. Nunley, Sean Elliott, Krishanu Ray, Greg A. Snyder, Sarah Jo Miller, Jason Kang, Catherine B. Blackwood, Kelly L. Weaver, William T. Witt, Annalisa B. Huckaby, Gage M. Pyles, Tammy Clark, Saif Al Qatarneh, George K. Lewis, F. Heath Damron, Mariette Barbier
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
The rise of antimicrobial-resistant bacterial infections is a crucial health concern in the 21st century. In particular, antibiotic-resistant Pseudomonas aeruginosa causes difficult-to-treat infections associated with high morbidity and mortality. Un
Externí odkaz:
https://doaj.org/article/16ca99521a77434a82ba921b3d3424ac
Autor:
Ting Y. Wong, Katherine S. Lee, Brynnan P. Russ, Alexander M. Horspool, Jason Kang, Michael T. Winters, M. Allison Wolf, Nathaniel A. Rader, Olivia A. Miller, Morgane Shiflett, Jerilyn Izac, David Varisco, Emel Sen-Kilic, Casey Cunningham, Melissa Cooper, Holly A. Cyphert, Mariette Barbier, Ivan Martinez, Justin R. Bevere, Robert K. Ernst, F. Heath Damron
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-15 (2022)
Abstract SARS-CoV-2 is a viral respiratory pathogen responsible for the current global pandemic and the disease that causes COVID-19. All current WHO approved COVID-19 vaccines are administered through the muscular route. We have developed a prototyp
Externí odkaz:
https://doaj.org/article/a40c0192e3324a71bfdf16e0ee2c5eb9
Autor:
Katherine S. Lee, Brynnan P. Russ, Ting Y. Wong, Alexander M. Horspool, Michael T. Winters, Mariette Barbier, Justin R. Bevere, Ivan Martinez, F. Heath Damron, Holly A. Cyphert
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105038- (2022)
Summary: Severe outcomes from SARS-CoV-2 infection are highly associated with preexisting comorbid conditions like hypertension, diabetes, and obesity. We utilized the diet-induced obesity (DIO) model of metabolic dysfunction in K18-hACE2 transgenic
Externí odkaz:
https://doaj.org/article/b4c46f98984c47e498601c866b94392d
Autor:
Kelly L. Weaver, Catherine B. Blackwood, Alexander M. Horspool, Gage M. Pyles, Emel Sen-Kilic, Emily M. Grayson, Annalisa B. Huckaby, William T. Witt, Megan A. DeJong, M. Allison Wolf, F. Heath Damron, Mariette Barbier
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Over two decades ago acellular pertussis vaccines (aP) replaced whole cell pertussis vaccines (wP) in several countries. Since then, a resurgence in pertussis has been observed, which is hypothesized to be linked, in part, to waning immunity. To bett
Externí odkaz:
https://doaj.org/article/b03e1b6f45e14762b9f792aee88a0445
Autor:
Katherine S. Lee, Ting Y. Wong, Brynnan P. Russ, Alexander M. Horspool, Olivia A. Miller, Nathaniel A. Rader, Jerome P. Givi, Michael T. Winters, Zeriel Y. A. Wong, Holly A. Cyphert, James Denvir, Peter Stoilov, Mariette Barbier, Nadia R. Roan, Md. Shahrier Amin, Ivan Martinez, Justin R. Bevere, F. Heath Damron
Publikováno v:
PLoS ONE, Vol 17, Iss 8 (2022)
The COVID-19 pandemic has been fueled by SARS-CoV-2 novel variants of concern (VOC) that have increased transmissibility, receptor binding affinity, and other properties that enhance disease. The goal of this study is to characterize unique pathogene
Externí odkaz:
https://doaj.org/article/4e76a98aed98487287f58f4b580d61cb
Autor:
Alexander M. Horspool, Theodore Kieffer, Brynnan P. Russ, Megan A. DeJong, M. Allison Wolf, Jacqueline M. Karakiozis, Brice J. Hickey, Paolo Fagone, Danyel H. Tacker, Justin R. Bevere, Ivan Martinez, Mariette Barbier, Peter L. Perrotta, F. Heath Damron
Publikováno v:
mSphere, Vol 6, Iss 1 (2021)
The SARS-CoV-2 pandemic is continuing to impact the global population, and knowledge of the immune response to COVID-19 is still developing. This study assesses the interplay of different parts of the immune system during COVID-19 disease.
Externí odkaz:
https://doaj.org/article/7291606a068442be9db403b0d8e1d2b6
Autor:
Alexander M. Horspool, Howard C. Chang
Publikováno v:
Redox Biology, Vol 17, Iss , Pp 377-385 (2018)
Superoxide dismutase, an enzyme that converts superoxide into less-toxic hydrogen peroxide and oxygen, has been shown to mediate behavioral response to pathogens. However, it remains largely unknown how superoxide dismutase is regulated in the nervou
Externí odkaz:
https://doaj.org/article/ebaeb07a71d546a8aa33dd11610c1abb
Autor:
Katherine S. Lee, Brynnan P. Russ, Ting Y. Wong, Alexander M. Horspool, Michael T. Winters, Mariette Barbier, Justin R. Bevere, Ivan Martinez, F. Heath Damron, Holly A. Cyphert
SARS-CoV-2 infection results in wide-ranging disease manifestation from asymptomatic to potentially lethal. Infection poses an increased threat of severity to at-risk populations including those with hypertension, diabetes, and obesity. Type 2 Diabet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::585d4b846fd8d0389f56447444ca7122
https://doi.org/10.1101/2022.04.26.489580
https://doi.org/10.1101/2022.04.26.489580
Autor:
Ting Y. Wong, Alexander M. Horspool, Brynnan P. Russ, Chengjin Ye, Katherine S. Lee, Michael T. Winters, Justin R. Bevere, Olivia A. Miller, Nathaniel A. Rader, Melissa Cooper, Theodore Kieffer, Julien Sourimant, Alexander L. Greninger, Richard K. Plemper, James Denvir, Holly A. Cyphert, Mariette Barbier, Jordi B. Torrelles, Ivan Martinez, Luis Martinez-Sobrido, F. Heath Damron
Publikováno v:
Journal of Virology. 96
SARS-CoV-2 variants of concern (VoC) are impacting responses to the COVID-19 pandemic. Here, we utilized passive immunization using human convalescent plasma (HCP) obtained from a critically ill COVID-19 patient in the early pandemic to study the eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b79849e969f4db9ec0604d47bf75cdd
https://doi.org/10.1128/jvi.02184-21
https://doi.org/10.1128/jvi.02184-21
Autor:
Sophia M. Kenney, Alexander M. Horspool, Claire O. Kelly, M. Allison Wolf, Caleb A. Kisamore, Megan A. DeJong, Dylan T. Boehm, Emel Sen-Kilic, Ting Y. Wong, Mariette Barbier, Graham J. Bitzer, Justin R. Bevere, F. Heath Damron, Jason Kang, Jesse M. Hall
Publikováno v:
Infection and Immunity. 89
Bordetella pertussis is a highly contagious bacterium that is the causative agent of whooping cough (pertussis). Currently, acellular pertussis vaccines (aP, DTaP, and Tdap) are used to prevent pertussis disease. However, it is clear that the aP vacc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f1200bd29c316526dace021ec184203
https://doi.org/10.1128/iai.00304-21
https://doi.org/10.1128/iai.00304-21