Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Alexander M. Herrmann"'
Autor:
Christina B. Schroeter, Leoni Rolfes, K. S. Sophie Gothan, Joel Gruchot, Alexander M. Herrmann, Stefanie Bock, Luca Fazio, Antonia Henes, Venu Narayanan, Steffen Pfeuffer, Christopher Nelke, Saskia Räuber, Niklas Huntemann, Eduardo Duarte-Silva, Vera Dobelmann, Petra Hundehege, Heinz Wiendl, Katharina Raba, Patrick Küry, David Kremer, Tobias Ruck, Thomas Müntefering, Thomas Budde, Manuela Cerina, Sven G. Meuth
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-19 (2022)
Abstract Background Cladribine is a synthetic purine analogue that interferes with DNA synthesis and repair next to disrupting cellular proliferation in actively dividing lymphocytes. The compound is approved for the treatment of multiple sclerosis (
Externí odkaz:
https://doaj.org/article/58f69881c3e94968a5c457db1a7af330
Autor:
Petra Hundehege, Manuela Cerina, Susann Eichler, Christian Thomas, Alexander M Herrmann, Kerstin Göbel, Thomas Müntefering, Juncal Fernandez-Orth, Stefanie Bock, Venu Narayanan, Thomas Budde, Erwin-Josef Speckmann, Heinz Wiendl, Anna Schubart, Tobias Ruck, Sven G Meuth
Publikováno v:
Neural Regeneration Research, Vol 14, Iss 11, Pp 1950-1960 (2019)
Autoimmune diseases of the central nervous system (CNS) like multiple sclerosis (MS) are characterized by inflammation and demyelinated lesions in white and grey matter regions. While inflammation is present at all stages of MS, it is more pronounced
Externí odkaz:
https://doaj.org/article/047ceb78633e4f8ebf177bdbc57d621b
Autor:
Christina B. Schroeter, Christopher Nelke, Marcus Schewe, Lucas Spohler, Alexander M. Herrmann, Thomas Müntefering, Niklas Huntemann, Maria Kuzikov, Philip Gribbon, Sarah Albrecht, Stefanie Bock, Petra Hundehege, Lea Christine Neelsen, Thomas Baukrowitz, Guiscard Seebohm, Bernhard Wünsch, Stefan Bittner, Tobias Ruck, Thomas Budde, Sven G. Meuth
Publikováno v:
Biological Chemistry. 404:355-375
Modulation of two-pore domain potassium (K2P) channels has emerged as a novel field of therapeutic strategies as they may regulate immune cell activation and metabolism, inflammatory signals, or barrier integrity. One of these ion channels is the TWI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa2e41f4c813e43135fc555b8adb7961
https://doi.org/10.1515/hsz-2022-0266
https://doi.org/10.1515/hsz-2022-0266
Autor:
Christina B. Schroeter, Alexander M. Herrmann, Stefanie Bock, Anna Vogelsang, Susann Eichler, Philipp Albrecht, Sven G. Meuth, Tobias Ruck
Publikováno v:
Cells, Vol 10, Iss 3, p 651 (2021)
In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, the role of each central nervous system (CNS)-resident cell type during inflammation, neurodegeneration, and remission has been frequently addressed. Although
Externí odkaz:
https://doaj.org/article/69bb8e295ac44c58853560643c630f57
Autor:
Kerstin Göbel, Susann Pankratz, Chloi-Magdalini Asaridou, Alexander M. Herrmann, Stefan Bittner, Monika Merker, Tobias Ruck, Sarah Glumm, Friederike Langhauser, Peter Kraft, Thorsten F. Krug, Johanna Breuer, Martin Herold, Catharina C. Gross, Denise Beckmann, Adelheid Korb-Pap, Michael K. Schuhmann, Stefanie Kuerten, Ioannis Mitroulis, Clemens Ruppert, Marc W. Nolte, Con Panousis, Luisa Klotz, Beate Kehrel, Thomas Korn, Harald F. Langer, Thomas Pap, Bernhard Nieswandt, Heinz Wiendl, Triantafyllos Chavakis, Christoph Kleinschnitz, Sven G. Meuth
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Factor XII initiates the intrinsic blood coagulation cascade and the kinin system. Here the authors show that Factor XII is elevated in the blood of multiple sclerosis patients, activates dendritic cells via CD87 and cAMP, and its blockade inhibits i
Externí odkaz:
https://doaj.org/article/df39268cbc9348e48bfb9cdea92d808d
Autor:
Maren Lindner, Tobias Bopp, Stefanie Bock, Steffen Pfeuffer, Felix Luessi, Sven G. Meuth, Jochen Huehn, Thomas Pap, Marc Pawlitzki, Stefan Bittner, Marie Liebmann, Paul Marciniak, Leoni Rolfes, Stjepana Kovac, Johannes Roth, Gerd Meyer zu Hörste, Nils Opel, Patricia Seja, Derya Cengiz, Alexander M Herrmann, Achmet Imam Chasan, Stefan Floess, Tim Hahn, Luisa Klotz, Tobias Marschall, Björn Tackenberg, Erhard Wischmeyer, Thomas Budde, Julian A. Schreiber, Udo Dannlowski, Bernhard Wünsch, Tanja Kuhlmann, Christina B Schroeter, Heinz Wiendl, Tobias Ruck, Frank Döring, Guiscard Seebohm, Lukas Gola
Publikováno v:
Cell Research
It remains largely unclear how thymocytes translate relative differences in T cell receptor (TCR) signal strength into distinct developmental programs that drive the cell fate decisions towards conventional (Tconv) or regulatory T cells (Treg). Follo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca262f544366b983281a0eb149ac9be
https://doi.org/10.1038/s41422-021-00580-z
https://doi.org/10.1038/s41422-021-00580-z
Autor:
Stefan Bittner, Alexander M. Herrmann, Frauke Zipp, Sarah Lauks, Sven G. Meuth, Lisanne Korn, Martin Diebold, Felix Luessi, Simone König, Marie Liebmann, Andreas Schulte-Mecklenbeck, Claudia Janoschka, Nicholas Schwab, Heinz Wiendl, Stephan Schmidt, Stjepana Kovac, Tilman Schneider-Hohendorf, Stefanie Albrecht, Catharina C. Gross, Maria Eveslage, Tanja Kuhlmann, Tobias Derfuss, Luisa Klotz, Brigitte Wildemann
Publikováno v:
Brain. 144:3126-3141
Dimethyl fumarate, an approved treatment for relapsing-remitting multiple sclerosis, exerts pleiotropic effects on immune cells as well as CNS resident cells. Here, we show that dimethyl fumarate exerts a profound alteration of the metabolic profile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc39b88b5f8ea762bd40e7c36861f13
https://doi.org/10.1093/brain/awab307
https://doi.org/10.1093/brain/awab307
Autor:
Stefanie M. Hauck, Manfred Roesner, Alisha Koch, Thomas Werner, Amelie Bauer, Ruth Brack-Werner, Martha Schneider, Alexander M. Herrmann
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Sci. Rep. 10:1326 (2020)
Scientific Reports
Sci. Rep. 10:1326 (2020)
Scientific Reports
Overcoming the global health threat of HIV infection requires continuous pipelines of novel drug candidates. We identified the γ-pyrone polyketides Aureothin/Neoaureothin as potent hits by anti-HIV screening of an extensive natural compound collecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e0b856efe8cf4b95ad1c18a52c5cd8
http://link.springer.com/article/10.1038/s41598-020-57843-9
http://link.springer.com/article/10.1038/s41598-020-57843-9
Autor:
Christina B. Schroeter, Leoni Rolfes, K. S. Sophie Gothan, Joel Gruchot, Alexander M. Herrmann, Stefanie Bock, Luca Fazio, Antonia Henes, Venu Narayanan, Steffen Pfeuffer, Christopher Nelke, Saskia Räuber, Niklas Huntemann, Eduardo Duarte-Silva, Vera Dobelmann, Petra Hundehege, Heinz Wiendl, Katharina Raba, Patrick Küry, David Kremer, Tobias Ruck, Thomas Müntefering, Thomas Budde, Manuela Cerina, Sven G. Meuth
Publikováno v:
Journal of neuroinflammation. 19(1)
Background Cladribine is a synthetic purine analogue that interferes with DNA synthesis and repair next to disrupting cellular proliferation in actively dividing lymphocytes. The compound is approved for the treatment of multiple sclerosis (MS). Clad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac7a2003c1d01267af75ed9e405d3d87
https://pubmed.ncbi.nlm.nih.gov/36348455
https://pubmed.ncbi.nlm.nih.gov/36348455
Autor:
Alexander M. Herrmann, Paul M. D'Agostino, Zhengyi Qian, Hans-Peter Fiedler, Noémi Antal, Tobias A. M. Gulder, Ruth Brack-Werner, Torsten Bruhn, Martin Haslbeck
Publikováno v:
The Journal of Organic Chemistry. 85:664-673
Genome sequencing and bioinformatic analysis have identified numerous cryptic gene clusters that have the potential to produce novel natural products. Within this work, we identified a cryptic type II PKS gene cluster (skt) from Streptomyces sp. Tu 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7333bd1641d02789415a2b4dbc1c13a6
https://doi.org/10.1021/acs.joc.9b02741
https://doi.org/10.1021/acs.joc.9b02741