Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Alexander M. Greiner"'
Publikováno v:
Frontiers in Medicine, Vol 10 (2024)
BackgroundBrugada Syndrome (BrS) is an inherited arrhythmia syndrome in which mutations in the cardiac sodium channel SCN5A (NaV1.5) account for approximately 20% of cases. Mutations in sodium channel-modifying genes may account for additional BrS ca
Externí odkaz:
https://doaj.org/article/82adbee24fd64006912b1ec41b83ec11
Autor:
Jin-Young Yoon, Alexander M. Greiner, Julia S. Jacobs, Young-Rae Kim, William Kutschke, Daniel S. Matasic, Ajit Vikram, Ravinder R Gaddam, Haider Mehdi, Kaikobad Irani, Barry London
BackgroundDecreased peak sodium current (INa) and increased late sodium current (INa,L), through the cardiac sodium channel NaV1.5 encoded bySCN5A, cause arrhythmias. Many NaV1.5 post-translational modifications have been reported by us and others. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3c74438d44848f7213cdfb6c722b34a
https://doi.org/10.1101/2022.12.26.521675
https://doi.org/10.1101/2022.12.26.521675
Autor:
Gina M. Morgan, Mark S. Schmidt, Haider Mehdi, Jared M. McLendon, Ryan L. Boudreau, Alexander M. Greiner, Pravda Quinones, Jin-Young Yoon, Daniel S. Matasic, Barry London, Charles Brenner, Kaikobad Irani
Publikováno v:
J Mol Cell Cardiol
RationaleThe cardiac sodium channel NaV1.5, encoded by SCN5A, produces the rapidly inactivating depolarizing current INa that is responsible for the initiation and propagation of the cardiac action potential. Acquired and inherited dysfunction of NaV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d090e7eb0a9fac5899be64d80c8df2
https://doi.org/10.1016/j.yjmcc.2020.01.013
https://doi.org/10.1016/j.yjmcc.2020.01.013
Autor:
Alexander M Greiner, Margaret Freese, Gabriel Kringlen, Edward M Powers, Rebecca A Gutmann, Barry London
Publikováno v:
Circulation. 144
Introduction: Inherited long QT Syndrome (LQTS) is characterized by prolonged QTc intervals on electrocardiogram (EKG), ventricular arrhythmias and sudden death (SCD), and is caused by mutations in ion channel or ion-channel related genes. Inherited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3375f5bdd9a0458a2c5a0fe0473818b2
https://doi.org/10.1161/circ.144.suppl_1.13546
https://doi.org/10.1161/circ.144.suppl_1.13546
Publikováno v:
Medical Education. 52:826-837
OBJECTIVE Medical oaths express ethical values that are essential to the trust within the patient-physician relationship and medicine's commitment to society. However, the contents of oaths vary between medical schools and therefore raise questions a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df8019549aed33885e0ee9cd7cf48657
https://doi.org/10.1111/medu.13581
https://doi.org/10.1111/medu.13581
Publikováno v:
Transactions of the American Clinical and Climatological Association. 129
Inherited conditions that lead to cardiac arrhythmias and sudden cardiac death remain an important cause of morbidity and mortality. Identifying the genes responsible for these rare conditions can provide insights into the more common and heritable f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ce10767ae088a8e53315efe80a20d26
https://pubmed.ncbi.nlm.nih.gov/30166713
https://pubmed.ncbi.nlm.nih.gov/30166713
Publikováno v:
Nucleic Acids Research
The Escherichia coli lactose operon provides a paradigm for understanding gene control by DNA looping where the lac repressor (LacI) protein competes with RNA polymerase for DNA binding. Not all promoter loops involve direct competition between repre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b95f771afb88c6fc849050a6196820
http://europepmc.org/articles/PMC4027209
http://europepmc.org/articles/PMC4027209