Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Alexander M. Binshtok"'
Autor:
Ben Katz, Rachel Zaguri, Simon Edvardson, Channa Maayan, Orly Elpeleg, Shaya Lev, Elyad Davidson, Maximilian Peters, Shlomit Kfir-Erenfeld, Esther Berger, Shifa Ghazalin, Alexander M. Binshtok, Baruch Minke
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 3 (2023)
BACKGROUND Chronic pain is a debilitating illness with currently limited therapy, in part due to difficulties in translating treatments derived from animal models to patients. The transient receptor potential vanilloid 1 (TRPV1) channel is associated
Externí odkaz:
https://doaj.org/article/fe1454a850e94ad0923ecb61b7f966e0
Autor:
Calvin Wong, Omer Barkai, Feng Wang, Carolina Thörn Perez, Shaya Lev, Weihua Cai, Shannon Tansley, Noosha Yousefpour, Mehdi Hooshmandi, Kevin C. Lister, Mariam Latif, A. Claudio Cuello, Masha Prager-Khoutorsky, Jeffrey S. Mogil, Philippe Séguéla, Yves De Koninck, Alfredo Ribeiro-da-Silva, Alexander M. Binshtok, Arkady Khoutorsky
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 15 (2022)
The encoding of noxious stimuli into action potential firing is largely mediated by nociceptive free nerve endings. Tissue inflammation, by changing the intrinsic properties of the nociceptive endings, leads to nociceptive hyperexcitability and thus
Externí odkaz:
https://doaj.org/article/486d93f8afa440fda061b38bd05ee999
Autor:
Devora Gershon, Robert H. Negev-Goldstein, Lama Abd al Razzaq, Shaya Lev, Alexander M. Binshtok
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101224- (2022)
Summary: This protocol aims to measure ion dynamics in nociceptive terminal endings in intact mice in vivo. We describe viral injection of GCaMP6s + RFP into trigeminal ganglia (TG) of mice, followed by calcium imaging of corneal nociceptive terminal
Externí odkaz:
https://doaj.org/article/bfe2eafe1675497da89074a2a5305f17
Autor:
Hagit Neumann-Raizel, Asaf Shilo, Shaya Lev, Maxim Mogilevsky, Ben Katz, David Shneor, Yoav D. Shaul, Andreas Leffler, Alberto Gabizon, Rotem Karni, Alik Honigman, Alexander M. Binshtok
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Targeted delivery of therapeutic compounds to particular cell types such that they only affect the target cells is of great clinical importance since it can minimize undesired side effects. For example, typical chemotherapeutic treatments used in the
Externí odkaz:
https://doaj.org/article/5a682d4b168c4f9b80938d081e917a4c
Autor:
Fernando Aleixandre-Carrera, Nurit Engelmayer, David Ares-Suárez, María del Carmen Acosta, Carlos Belmonte, Juana Gallar, Víctor Meseguer, Alexander M. Binshtok
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 481 (2021)
Free nerve endings are key structures in sensory transduction of noxious stimuli. In spite of this, little is known about their functional organization. Transient receptor potential (TRP) channels have emerged as key molecular identities in the senso
Externí odkaz:
https://doaj.org/article/02fe28865ca24552942e219b235967bd
Autor:
Hodaya Leibovich, Nahum Buzaglo, Shlomo Tsuriel, Liat Peretz, Yaki Caspi, Ben Katz, Shaya Lev, David Lichtstein, Alexander M. Binshtok
Publikováno v:
Cells, Vol 9, Iss 4, p 1007 (2020)
An injury to peripheral nerves leads to skin denervation, which often is followed by increased pain sensitivity of the denervated areas and the development of neuropathic pain. Changes in innervation patterns during the reinnervation process of the d
Externí odkaz:
https://doaj.org/article/b09c0724f8994cfc8414a75b9c186128
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Peripheral nociceptive neurons encode and convey injury-inducing stimuli toward the central nervous system. In normal conditions, tight control of nociceptive resting potential prevents their spontaneous activation. However, in many pathological cond
Externí odkaz:
https://doaj.org/article/c98e7d3618be4e05876e094fc9108922
Autor:
Zvi Granot, Alexander M. Binshtok, Zvi G. Fridlender, Rotem Karni, Yasuo Mori, Yoav D. Shaul, Rami I. Aqeilan, Leonor Cohen-Daniel, Ronit V. Sionov, Merav E. Shaul, Lola Polyansky, Shaya Lev, Saleh Khawaled, Janna Michaeli, Ben Katz, Tanya Fainsod-Levi, Yaki Caspi, Maya Gershkovitz
Supplemental Figure S3. TRPM2 expression is associated with prolonged progression free survival in breast cancer patients. Kaplan-Meyer analysis of recurrence free survival (RFS, upper panels) and distant metastasis free survival (DMFS, lower panels)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b7eda64ead6bedf09349efccd815470
https://doi.org/10.1158/0008-5472.22419333
https://doi.org/10.1158/0008-5472.22419333
Autor:
Zvi Granot, Alexander M. Binshtok, Zvi G. Fridlender, Rotem Karni, Yasuo Mori, Yoav D. Shaul, Rami I. Aqeilan, Leonor Cohen-Daniel, Ronit V. Sionov, Merav E. Shaul, Lola Polyansky, Shaya Lev, Saleh Khawaled, Janna Michaeli, Ben Katz, Tanya Fainsod-Levi, Yaki Caspi, Maya Gershkovitz
Supplemental figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b15404c9b9d9b90b6ba436c907efac
https://doi.org/10.1158/0008-5472.22419330.v1
https://doi.org/10.1158/0008-5472.22419330.v1
Autor:
Zvi Granot, Alexander M. Binshtok, Zvi G. Fridlender, Rotem Karni, Yasuo Mori, Yoav D. Shaul, Rami I. Aqeilan, Leonor Cohen-Daniel, Ronit V. Sionov, Merav E. Shaul, Lola Polyansky, Shaya Lev, Saleh Khawaled, Janna Michaeli, Ben Katz, Tanya Fainsod-Levi, Yaki Caspi, Maya Gershkovitz
Neutrophils play a critical role in cancer, with both protumor and antitumor neutrophil subpopulations reported. The antitumor neutrophil subpopulation has the capacity to kill tumor cells and limit metastatic spread, yet not all tumor cells are equa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60900c75e0c1f47d7b26d6d7e194382b
https://doi.org/10.1158/0008-5472.c.6510354.v1
https://doi.org/10.1158/0008-5472.c.6510354.v1