Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Alexander M Binshtok"'
Publikováno v:
Neurobiology of Pain, Vol 14, Iss , Pp 100139- (2023)
The excitatory and inhibitory interneurons of superficial laminae I-II of the spinal dorsal horn (SDH) receive and process pain-related information from the primary afferents and transmit it to the brain via the projection neurons. Thus, the interact
Externí odkaz:
https://doaj.org/article/2410f4601021470a9c4b152c74a1ea18
Autor:
Hossain Md Zakir, Rahman Md Mostafeezur, Akiko Suzuki, Suzuro Hitomi, Ikuko Suzuki, Takeyasu Maeda, Kenji Seo, Yoshiaki Yamada, Kensuke Yamamura, Shaya Lev, Alexander M Binshtok, Koichi Iwata, Junichi Kitagawa
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44023 (2012)
Increased expression of the transient receptor potential vanilloid 1 (TRPV1) channels, following nerve injury, may facilitate the entry of QX-314 into nociceptive neurons in order to achieve effective and selective pain relief. In this study we hypot
Externí odkaz:
https://doaj.org/article/7577f2ec4c214c5f9809b9ba1e8ed55e
Autor:
Zvi Granot, Alexander M. Binshtok, Zvi G. Fridlender, Rotem Karni, Yasuo Mori, Yoav D. Shaul, Rami I. Aqeilan, Leonor Cohen-Daniel, Ronit V. Sionov, Merav E. Shaul, Lola Polyansky, Shaya Lev, Saleh Khawaled, Janna Michaeli, Ben Katz, Tanya Fainsod-Levi, Yaki Caspi, Maya Gershkovitz
Supplemental Figure S3. TRPM2 expression is associated with prolonged progression free survival in breast cancer patients. Kaplan-Meyer analysis of recurrence free survival (RFS, upper panels) and distant metastasis free survival (DMFS, lower panels)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b7eda64ead6bedf09349efccd815470
https://doi.org/10.1158/0008-5472.22419333
https://doi.org/10.1158/0008-5472.22419333
Autor:
Zvi Granot, Alexander M. Binshtok, Zvi G. Fridlender, Rotem Karni, Yasuo Mori, Yoav D. Shaul, Rami I. Aqeilan, Leonor Cohen-Daniel, Ronit V. Sionov, Merav E. Shaul, Lola Polyansky, Shaya Lev, Saleh Khawaled, Janna Michaeli, Ben Katz, Tanya Fainsod-Levi, Yaki Caspi, Maya Gershkovitz
Supplemental figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b15404c9b9d9b90b6ba436c907efac
https://doi.org/10.1158/0008-5472.22419330.v1
https://doi.org/10.1158/0008-5472.22419330.v1
Autor:
Zvi Granot, Alexander M. Binshtok, Zvi G. Fridlender, Rotem Karni, Yasuo Mori, Yoav D. Shaul, Rami I. Aqeilan, Leonor Cohen-Daniel, Ronit V. Sionov, Merav E. Shaul, Lola Polyansky, Shaya Lev, Saleh Khawaled, Janna Michaeli, Ben Katz, Tanya Fainsod-Levi, Yaki Caspi, Maya Gershkovitz
Neutrophils play a critical role in cancer, with both protumor and antitumor neutrophil subpopulations reported. The antitumor neutrophil subpopulation has the capacity to kill tumor cells and limit metastatic spread, yet not all tumor cells are equa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60900c75e0c1f47d7b26d6d7e194382b
https://doi.org/10.1158/0008-5472.c.6510354.v1
https://doi.org/10.1158/0008-5472.c.6510354.v1
Autor:
Ben Katz, Rachel Zaguri, Simon Edvardson, Channa Maayan, Orly Elpeleg, Shaya Lev, Elyad Davidson, Maximilian Peters, Shlomit Kfir-Erenfeld, Esther Berger, Shifa Ghazalin, Alexander M. Binshtok, Baruch Minke
Publikováno v:
Journal of Clinical Investigation. 133
Chronic-pain is a debilitating illness that has become exceedingly widespread with currently limited treatments. Differences in the molecular signature of nociceptors, have been demonstrated between human and the commonly-used mouse model, suggesting
Autor:
Fernando Aleixandre-Carrera, Nurit Engelmayer, David Ares-Suárez, María del Carmen Acosta, Carlos Belmonte, Juana Gallar, Víctor Meseguer, Alexander M. Binshtok
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 481 (2021)
Free nerve endings are key structures in sensory transduction of noxious stimuli. In spite of this, little is known about their functional organization. Transient receptor potential (TRP) channels have emerged as key molecular identities in the senso
Externí odkaz:
https://doaj.org/article/02fe28865ca24552942e219b235967bd
Autor:
Calvin Wong, Omer Barkai, Feng Wang, Carolina Thörn Perez, Shaya Lev, Weihua Cai, Shannon Tansley, Noosha Yousefpour, Mehdi Hooshmandi, Kevin C. Lister, Mariam Latif, A. Claudio Cuello, Masha Prager-Khoutorsky, Jeffrey S. Mogil, Philippe Séguéla, Yves De Koninck, Alfredo Ribeiro-da-Silva, Alexander M. Binshtok, Arkady Khoutorsky
Publikováno v:
Journal of Clinical Investigation. 132
The encoding of noxious stimuli into action potential firing is largely mediated by nociceptive free nerve endings. Tissue inflammation, by changing the intrinsic properties of the nociceptive endings, leads to nociceptive hyperexcitability and thus
Autor:
Yaki Caspi, Michael Mazar, Yishai Kushnir, Yoav Mazor, Ben Katz, Shaya Lev, Alexander M Binshtok
Activity-dependent structural plasticity of axon initial segment (AIS) regulates neuronal excitability, thus fine-tuning neuronal and overall network output. Here using behavioral, immunohistochemical, electrophysiological and computational approache
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebafa8eed1308620ca2ec36ebe368533
https://doi.org/10.1101/2022.07.24.501281
https://doi.org/10.1101/2022.07.24.501281
Autor:
Ronald Udasin, Anwesha Sil, Elia Zomot, Hadas Achildiev Cohen, Jozafina Haj, Nurit Engelmayer, Shaya Lev, Alexander M. Binshtok, Yuval Shaked, Michael A. Kienzler, Raz Palty
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(13)
Significance Calcium release–activated calcium (CRAC) channels play key roles in the regulation of cellular signaling, transcription, and migration. Here, we describe the design, chemical synthesis, and characterization of photoswitchable channel i