Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Alexander Mülsch"'
Autor:
Hans-Hermann Hoepken, Suzana Gispert, Blas Morales, Oliver Wingerter, Domenico Del Turco, Alexander Mülsch, Robert L. Nussbaum, Klaus Müller, Stefan Dröse, Ulrich Brandt, Thomas Deller, Brunhilde Wirth, Alexei P. Kudin, Wolfram S. Kunz, Georg Auburger
Publikováno v:
Neurobiology of Disease, Vol 25, Iss 2, Pp 401-411 (2007)
Oxidative stress and protein aggregation are biochemical hallmarks of Parkinson’s disease (PD), a frequent sporadic late-onset degenerative disorder particularly of dopaminergic neurons in the substantia nigra, resulting in impaired spontaneous mov
Externí odkaz:
https://doaj.org/article/13394e1023644fa291cb79c68e130fa8
Publikováno v:
Journal of Neurochemistry. 62:1524-1529
In contrast to the predominantly particulate, Ca2+/calmodulin-dependent nitric oxide (NO) synthase in endothelial cells, the corresponding neuronal isoenzyme is considered to be mainly soluble, presumably owing to the lack of a posttranslational myri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69a46c6093056af20296b96883b4efd
https://doi.org/10.1046/j.1471-4159.1994.62041524.x
https://doi.org/10.1046/j.1471-4159.1994.62041524.x
Autor:
Stefan Schildknecht, C. Huth, Y. Nazirisadeh, Nikos Tsilimingas, K. Kaiser, Matthias Oelze, Thomas Münzel, Andreas Daiber, Meike Coldewey, Volker Ullrich, Alexander Mülsch, Markus Bachschmid
Publikováno v:
Biochemical and Biophysical Research Communications. 338:1865-1874
The hemodynamic and anti-ischemic effects of nitroglycerin (GTN) are rapidly blunted as a result of the development of nitrate tolerance. Hydralazine has been shown to prevent tolerance in experimental and clinical studies, all of which may be at lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03dc0cfd812989260986f108f7a03c1f
https://doi.org/10.1016/j.bbrc.2005.10.106
https://doi.org/10.1016/j.bbrc.2005.10.106
Autor:
Matthias Oelze, Alexander Mülsch, Thomas Münzel, Andreas Daiber, Hanke Mollnau, Ulrich Hink, Ascan Warnholtz
Publikováno v:
The American Journal of Cardiology. 96:25-36
The hemodynamic and anti-ischemic effects of nitroglycerin (NTG) are rapidly blunted as a result of the development of nitrate tolerance. With initiation of NTG therapy, it is possible to detect neurohormonal activation and intravascular volume expan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a185a2eecbb9117b50a576af59e0fafb
https://doi.org/10.1016/j.amjcard.2005.07.030
https://doi.org/10.1016/j.amjcard.2005.07.030
Publikováno v:
Hypertension. 45:1200-1206
In aged spontaneously hypertensive rats (SHR), vasorelaxant responses to NO are attenuated compared with normotensive control rats (Wistar-Kyoto [WKY]) because of a decreased expression of the important NO receptor soluble guanylyl cyclase (sGC). Bec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0919f790e74c65cc7d3d3d76a1ff9e8
https://doi.org/10.1161/01.hyp.0000165674.58470.8f
https://doi.org/10.1161/01.hyp.0000165674.58470.8f
Autor:
Robert Feil, Ulrich Walter, Franz Hofmann, Thomas Münzel, Suzanne M. Lohmann, Alexander Mülsch
Publikováno v:
Circulation. 108:2172-2183
Despite impressive medical advances1 that have led to diminished cardiovascular death rates in some countries over the past 20 years, cardiovascular disease remains the leading cause of death in developed countries such as the United States. This pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ab88a023ff00e1fe84f1a02ea6f4b03
https://doi.org/10.1161/01.cir.0000094403.78467.c3
https://doi.org/10.1161/01.cir.0000094403.78467.c3
Publikováno v:
Journal of Biological Chemistry. 278:2377-2383
We investigated the molecular mechanism of cyclic GMP-induced down-regulation of soluble guanylyl cyclase expression in rat aorta. 3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1), an allosteric activator of this enzyme, decreased the expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326987638d744ac40e6bd7b9f5974a77
https://doi.org/10.1074/jbc.m206453200
https://doi.org/10.1074/jbc.m206453200
Publikováno v:
Free Radical Biology and Medicine. 31:1360-1367
Soluble guanylyl cyclase (sGC) is a key enzyme of the *NO/cGMP pathway. Many cardiovascular disorders are associated with reduced *NO-mediated effects, while vascular superoxide (O(2)*(-)) production is increased. Both radicals rapidly react to perox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73bf52dfbc5f6851bd400b0886546d9
https://doi.org/10.1016/s0891-5849(01)00706-7
https://doi.org/10.1016/s0891-5849(01)00706-7
Publikováno v:
Free Radical Biology and Medicine. 27:636-646
The nitrogen monoxide radical (NO ) forms paramagnetic mono- and dinitrosyl–iron complexes in biologic tissues. To establish a noninvasive technique for in vivo NO imaging, we evaluated the suitability of these complexes as magnetic resonance (MR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a26e53e96162878144a8900a6079ea
https://doi.org/10.1016/s0891-5849(99)00122-7
https://doi.org/10.1016/s0891-5849(99)00122-7
Autor:
Alexander Mülsch, David G. Harrison, Hussein Yigit, Roland Macharzina, Ulrich Hink, Thomas Münzel
Publikováno v:
British Journal of Pharmacology. 127:1224-1230
We assessed whether pharmacological inhibition of CuZn-superoxide dismutase (SOD) mimics the molecular mechanism of either in vitro or in vivo nitrovasodilator tolerance. In endothelium-intact aortic rings from in vivo tolerant rabbits the GTN- and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a171d88eae73665305404da81516b89c
https://doi.org/10.1038/sj.bjp.0702622
https://doi.org/10.1038/sj.bjp.0702622