Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Alexander M, Kulminski"'
Autor:
Alexander M. Kulminski, Ethan Jain‐Washburn, Ian Philipp, Yury Loika, Elena Loiko, Irina Culminskaya
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION The variability in apolipoprotein E (APOE) ε4‐attributed susceptibility to Alzheimer's disease (AD) across ancestries, sexes, and ages may stem from the modulating effects of other genetic variants. METHODS We examined associ
Externí odkaz:
https://doaj.org/article/f942fc4def444aaf801aad1a51aec5af
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Elucidating regulatory effects of Alzheimer’s disease (AD)-associated genetic variants is critical for unraveling their causal pathways and understanding the pathology. However, their cell-type-specific regulatory mechanisms in the brain r
Externí odkaz:
https://doaj.org/article/72fcfb13a2cd456fb3aace7c55f95257
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
The APOE ε2, ε3, and ε4 alleles differentially impact various complex diseases and traits. We examined whether these alleles modulated associations of 94 single-nucleotide polymorphisms (SNPs) harbored by 26 genes in 19q13.3 region with 217 plasma
Externí odkaz:
https://doaj.org/article/d9da6cdfd31e4a59a52ac8077b1b005f
Autor:
Liang He, Jose Davila-Velderrain, Tomokazu S. Sumida, David A. Hafler, Manolis Kellis, Alexander M. Kulminski
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
The application of negative binomial mixed models (NBMMs) to single-cell data is computationally demanding. To address this issue, Liang He et al. have developed NEBULA, an efficient algorithm that can analyze differential gene expression or co-expre
Externí odkaz:
https://doaj.org/article/1604a175b02d438a8389ecd99650f39c
Autor:
Liang He, Yury Loika, Yongjin Park, Genotype Tissue Expression (GTEx) consortium, David A. Bennett, Manolis Kellis, Alexander M. Kulminski, for the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Despite recent discoveries in genome-wide association studies (GWAS) of genomic variants associated with Alzheimer’s disease (AD), its underlying biological mechanisms are still elusive. The discovery of novel AD-associated genetic variant
Externí odkaz:
https://doaj.org/article/393a12c86dd24b81977b2a9a59599c43
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-21 (2019)
Abstract Background Alzheimer’s disease (AD) is the most common cause of dementia in the elderly and the sixth leading cause of death in the United States. AD is mainly considered a complex disorder with polygenic inheritance. Despite discovering m
Externí odkaz:
https://doaj.org/article/0c7ad387e3fe45b38c0b5445cb52460f
Autor:
Yury Loika, Elena Loiko, Fan Feng, Eric Stallard, Anatoliy I. Yashin, Konstantin Arbeev, Allison L. Kuipers, Mary F. Feitosa, Michael A. Province, Alexander M. Kulminski
Publikováno v:
Aging. 15:3249-3272
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7da835e1e1a97522038f861a6b5482d
https://doi.org/10.18632/aging.204665
https://doi.org/10.18632/aging.204665
Autor:
Konstantin G. Arbeev, Olivia Bagley, Svetlana V. Ukraintseva, Hongzhe Duan, Alexander M. Kulminski, Eric Stallard, Deqing Wu, Kaare Christensen, Mary F. Feitosa, Bharat Thyagarajan, Joseph M. Zmuda, Anatoliy I. Yashin
Publikováno v:
Frontiers in Public Health, Vol 8 (2020)
Biological aging results in changes in an organism that accumulate over age in a complex fashion across different regulatory systems, and their cumulative effect manifests in increased physiological dysregulation (PD) and declining robustness and res
Externí odkaz:
https://doaj.org/article/e540a4d0929e41e39f32ad1b4e8ee8c5
Autor:
Alexander M. Kulminski, Leonardo Shu, Yury Loika, Liang He, Alireza Nazarian, Konstantin Arbeev, Svetlana Ukraintseva, Anatoliy Yashin, Irina Culminskaya
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Apolipoprotein E (APOE) ε2 and ε4 alleles encoded by rs7412 and rs429358 polymorphisms, respectively, are landmark contra and pro “risk” factors for Alzheimer's disease (AD). Methods We examined differences in linkage dise
Externí odkaz:
https://doaj.org/article/f05849ada38a4a9b97436d5ad301e47c
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction As a multifactorial polygenic disorder, Alzheimer's disease (AD) can be associated with complex haplotypes or compound genotypes. Methods We examined associations of 4960 single nucleotide polymorphism (SNP) triples, comprising
Externí odkaz:
https://doaj.org/article/204760467c9a4268896f1487ce7e27e4