Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Alexander M, Barclay"'
Autor:
Dhruva D. Dhavale, Alexander M. Barclay, Collin G. Borcik, Katherine Basore, Deborah A. Berthold, Isabelle R. Gordon, Jialu Liu, Moses H. Milchberg, Jennifer Y. O’Shea, Michael J. Rau, Zachary Smith, Soumyo Sen, Brock Summers, John Smith, Owen A. Warmuth, Richard J. Perrin, Joel S. Perlmutter, Qian Chen, James A. J. Fitzpatrick, Charles D. Schwieters, Emad Tajkhorshid, Chad M. Rienstra, Paul T. Kotzbauer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The defining feature of Parkinson disease (PD) and Lewy body dementia (LBD) is the accumulation of alpha-synuclein (Asyn) fibrils in Lewy bodies and Lewy neurites. Here we develop and validate a method to amplify Asyn fibrils extracted from
Externí odkaz:
https://doaj.org/article/34678621ec164ec7a36f533a9c6f2b2a
Autor:
Alexander M. Barclay, Dhruva D. Dhavale, Collin G. Borcik, Moses H. Milchberg, Paul T. Kotzbauer, Chad M. Rienstra
Fibrils of the protein α-synuclein (Asyn) are implicated in the pathogenesis of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. Numerous forms of Asyn fibrils have been studied by solid-state NMR and resonance assignments have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be0010cb32901eaae13812b09162837e
https://doi.org/10.21203/rs.3.rs-2460685/v1
https://doi.org/10.21203/rs.3.rs-2460685/v1
13C and15N Resonance Assignments of Alpha Synuclein Fibrils Amplified from Lewy Body Dementia Tissue
Autor:
Alexander M. Barclay, Dhruva D. Dhavale, Collin G. Borcik, Moses H. Milchberg, Paul T. Kotzbauer, Chad M. Rienstra
Fibrils of the protein α-synuclein (Asyn) are implicated in the pathogenesis of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. Numerous forms of Asyn fibrils have been studied by solid-state NMR and resonance assignments have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3486487f4dfaed3582efe499cf3da43
https://doi.org/10.1101/2023.01.09.523339
https://doi.org/10.1101/2023.01.09.523339
Autor:
Dhruva D. Dhavale, Alexander M. Barclay, Collin G. Borcik, Katherine Basore, Isabelle R. Gordon, Jialu Liu, Moses H. Milchberg, Jennifer O’shea, Michael J. Rau, Zachary Smith, Soumyo Sen, Brock Summers, John Smith, Owen A. Warmuth, Qian Chen, James A. J. Fitzpatrick, Charles D. Schwieters, Emad Tajkhorshid, Chad M. Rienstra, Paul T. Kotzbauer
Publikováno v:
bioRxiv
The defining feature of Parkinson disease (PD) and Lewy body dementia (LBD) is the accumulation of alpha-synuclein (Asyn) fibrils in Lewy bodies and Lewy neurites. We developed and validated a novel method to amplify Asyn fibrils extracted from LBD p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0029ccdc5a8007d47e24b582faaa71fb
https://doi.org/10.1101/2023.01.09.523303
https://doi.org/10.1101/2023.01.09.523303
Autor:
Alessandra S Caporale, Alexander M Barclay, Jing Xu, Hengyi Rao, Hyunyeol Lee, Michael C Langham, John A Detre, Felix W Wehrli
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. :0271678X2311644
Sleep, a state of reduced consciousness, affects brain oxygen metabolism and lowers cerebral metabolic rate of oxygen (CMRO2). Previously, we quantified CMRO2 during sleep via Fick’s Principle, with a single-band MRI sequence measuring both hemoglo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b2c0717966af96d62542fd64c3b6d11
https://doi.org/10.1177/0271678x231164423
https://doi.org/10.1177/0271678x231164423
Autor:
Chad M. Rienstra, Hyosung An, Xing Jiang, Alexander M. Barclay, John W. Smith, Emad Tajkhorshid, Edwin G. Moore, Jeffrey S. Moore, Giuseppe Léonardo Licari, Qian Chen
Publikováno v:
ACS applied nano materials. 3(2)
The assembly of proteins into amyloid fibrils has become linked not only with the progression of myriad human diseases, but also important biological functions. Understanding and controlling the formation, structure, and stability of amyloid fibrils
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89be799ec5c6b1b5168b8ac41580bb63
https://pubmed.ncbi.nlm.nih.gov/32149271
https://pubmed.ncbi.nlm.nih.gov/32149271
Autor:
Chad M. Rienstra, Joseph M. Courtney, Dhruva Dhavale, Paul T. Kotzbauer, Alexander M. Barclay
Publikováno v:
Biomolecular NMR Assignments. 12:195-199
Fibrils of the protein α-synuclein are implicated in the pathogenesis of Parkinson’s disease and related neurodegenerative disorders. We have reported a high-resolution structure (PDB 2N0A) of an α-synuclein fibril form prepared by in vitro incub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78642f0b5fc9368d9e7185bd71872149
https://doi.org/10.1007/s12104-018-9808-5
https://doi.org/10.1007/s12104-018-9808-5
Publikováno v:
Methods in Molecular Biology ISBN: 9781493929771
Solid-state NMR spectroscopy (SSNMR) is an established and invaluable tool for the study of amyloid fibril structure with atomic-level detail. Optimization of the homogeneity and concentration of fibrils enhances the resolution and sensitivity of SSN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fff9fe9f4e0d8185a643b32ad8b4f07
https://doi.org/10.1007/978-1-4939-2978-8_11
https://doi.org/10.1007/978-1-4939-2978-8_11
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1345
Solid-state NMR spectroscopy (SSNMR) is an established and invaluable tool for the study of amyloid fibril structure with atomic-level detail. Optimization of the homogeneity and concentration of fibrils enhances the resolution and sensitivity of SSN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b1cf4bf101842607eb6dff28129b88f
https://pubmed.ncbi.nlm.nih.gov/26453212
https://pubmed.ncbi.nlm.nih.gov/26453212
Autor:
Amy Kendall, Joseph M. Courtney, Marcus D. Tuttle, Gemma Comellas, Jae K Kim, Charles D. Schwieters, Kathryn D. Kloepper, William Wan, Chad M. Rienstra, Gerald Stubbs, Alexander M. Barclay, Virginia M.-Y. Lee, Jimin George, Andrew J. Nieuwkoop, Dustin J. Covell, Deborah A. Berthold
Publikováno v:
Nature structural & molecular biology
Misfolded α-synuclein amyloid fibrils are the principal components of Lewy bodies and neurites, hallmarks of Parkinson's disease (PD). We present a high-resolution structure of an α-synuclein fibril, in a form that induces robust pathology in prima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f665dd92fd86642b9319246b2d6829ba
https://pubmed.ncbi.nlm.nih.gov/27018801
https://pubmed.ncbi.nlm.nih.gov/27018801