Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Alexander Lund Nielsen"'
Autor:
Lewis Turner, Alexander Lund Nielsen, Lucy Lin, Antonio J. Campedelli, Nicholas Silvaggi, Jason Chen, Amanda E. Wakefield, Karen N. Allen, Kim janda
We have used crystal structures and molecular modeling to evaluate inhibitor binding modes and design a series of compounds to take advantage of a new, cryptic, hydrophobic sub-pocket. This is a classical SBDD approach to improving enzyme/inhibitor i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425e6bcc31af5c195b67705f6cc42018
https://doi.org/10.26434/chemrxiv.14743893
https://doi.org/10.26434/chemrxiv.14743893
Publikováno v:
Nielsen, A L & Olsen, C A 2020, ' Finding the gas pedal on a slow sirtuin ', Journal of Biological Chemistry, no. 295, pp. 400-401 . https://doi.org/10.1074/jbc.H120.012534
The class III histone deacetylase sirtuin 6 (SIRT6) modulates numerous functions in the cell by deacetylating histone lysine residues. Interestingly, SIRT6's efficiency in in vitro experiments is far greater against substrates carrying long-chain fat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3860c816667beccafa4545824a2ee0b7
https://doi.org/10.1074/jbc.h120.012534
https://doi.org/10.1074/jbc.h120.012534
Publikováno v:
University of Copenhagen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1be005d9a201861e93ef4065298023a1
https://curis.ku.dk/portal/en/publications/potent-and-selective-inhibition-of-sirtuin-2-deacylation(77b9d723-654f-4bdb-8e12-17585e4b10cc).html
https://curis.ku.dk/portal/en/publications/potent-and-selective-inhibition-of-sirtuin-2-deacylation(77b9d723-654f-4bdb-8e12-17585e4b10cc).html