Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Alexander Loewer"'
Autor:
Niklas Kolbe, Lorenz Hexemer, Lukas-Malte Bammert, Alexander Loewer, Mária Lukáčová-Medvid'ová, Stefan Legewie
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1010266 (2022)
Cells sense their surrounding by employing intracellular signaling pathways that transmit hormonal signals from the cell membrane to the nucleus. TGF-β/SMAD signaling encodes various cell fates, controls tissue homeostasis and is deregulated in dise
Externí odkaz:
https://doaj.org/article/3bb50be3c3134aec800dc9093ba0e88b
Autor:
Dhana Friedrich, Laura Friedel, Ana Finzel, Andreas Herrmann, Stephan Preibisch, Alexander Loewer
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 12, Pp 1-20 (2019)
Abstract Discontinuous transcription has been described for different mammalian cell lines and numerous promoters. However, our knowledge of how the activity of individual promoters is adjusted by dynamic signaling inputs from transcription factors i
Externí odkaz:
https://doaj.org/article/3bc9af6ae33448de90effc61398d900a
A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics.
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 6, p e1007901 (2020)
The transcription factors NF-κB and p53 are key regulators in the genotoxic stress response and are critical for tumor development. Although there is ample evidence for interactions between both networks, a comprehensive understanding of the crossta
Externí odkaz:
https://doaj.org/article/c75db1df7f4a4c2896588f994787f4d4
Autor:
Jette Strasen, Uddipan Sarma, Marcel Jentsch, Stefan Bohn, Caibin Sheng, Daniel Horbelt, Petra Knaus, Stefan Legewie, Alexander Loewer
Publikováno v:
Molecular Systems Biology, Vol 14, Iss 1, Pp 1-17 (2018)
Abstract The cytokine TGFβ provides important information during embryonic development, adult tissue homeostasis, and regeneration. Alterations in the cellular response to TGFβ are involved in severe human diseases. To understand how cells encode t
Externí odkaz:
https://doaj.org/article/5c6ce0a8d8d9404f8c43b4683108192e
Autor:
Caibin Sheng, Isabella-Hilda Mendler, Sara Rieke, Petra Snyder, Marcel Jentsch, Dhana Friedrich, Barbara Drossel, Alexander Loewer
Publikováno v:
Cell Reports, Vol 27, Iss 1, Pp 48-58.e7 (2019)
Summary: To enable reliable cell fate decisions, mammalian cells need to adjust their responses to dynamically changing internal states by rewiring the corresponding signaling networks. Here, we combine time-lapse microscopy of endogenous fluorescent
Externí odkaz:
https://doaj.org/article/fe6e3846d07b41d2b884127f8c9a0d60
Publikováno v:
Molecular Systems Biology, Vol 7, Iss 1, Pp 1-8 (2011)
Abstract Many biological networks respond to various inputs through a common signaling molecule that triggers distinct cellular outcomes. One potential mechanism for achieving specific input–output relationships is to trigger distinct dynamical pat
Externí odkaz:
https://doaj.org/article/6afb3fc31a514c0caf7c4dd390972814
Autor:
Elina Wiechens, Flavia Vigliotti, Konstantin Riege, Alena van Bömmel, Katjana Schwab, Ivonne Görlich, Martin Bens, Robert Schwarz, Arne Sahm, Marco Groth, Alexander Loewer, Steve Hoffmann, Martin Fischer
The coordination of transcription through enhancers and promoters is a fundamental process that has a central role in development and disease 1–3. Convergent transcription, i.e., the collision of sense and antisense transcription, is ubiquitous in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6d3b3396fd4a11fd6948f20a304b513
https://doi.org/10.21203/rs.3.rs-2803901/v1
https://doi.org/10.21203/rs.3.rs-2803901/v1
State- and stimulus-specific dynamics of SMAD signaling determine fate decisions in individual cells
Autor:
Stefan Bohn, Lorenz Hexemer, Zixin Huang, Laura Strohmaier, Sonja Lenhardt, Stefan Legewie, Alexander Loewer
Publikováno v:
Proceedings of the National Academy of Sciences. 120
SMAD-mediated signaling regulates apoptosis, cell cycle arrest, and epithelial-to-mesenchymal transition to safeguard tissue homeostasis. However, it remains elusive how the relatively simple pathway can determine such a broad range of cell fate deci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5c9e30e272dd48c59680520af79561c
https://doi.org/10.1073/pnas.2210891120
https://doi.org/10.1073/pnas.2210891120
Publikováno v:
Methods in Molecular Biology ISBN: 9781071630075
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2b01b03f36b43afef35329ade25d869
https://doi.org/10.1007/978-1-0716-3008-2_12
https://doi.org/10.1007/978-1-0716-3008-2_12
Autor:
Laura Friedel, Alexander Loewer
Publikováno v:
The FEBS Journal. 289:40-52
p53 plays a central role in defending the genomic integrity of our cells. In response to genotoxic stress, this tumour suppressor orchestrates the expression of hundreds of target genes, which induce a variety of cellular outcomes ranging from damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3cde893d38728c26fecc8de3e2b29d
https://doi.org/10.1111/febs.15767
https://doi.org/10.1111/febs.15767