Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alexander Liesum"'
Autor:
Sven Ruf, Britta Böhnisch, Katja Kroll, Christian Buning, Alexander Liesum, Herman Schreuder, Thorsten Sadowski
Publikováno v:
Biochemical and Biophysical Research Communications. 445:451-456
The lysosomal serine carboxypeptidase cathepsin A is involved in the breakdown of peptide hormones like endothelin and bradykinin. Recent pharmacological studies with cathepsin A inhibitors in rodents showed a remarkable reduction in cardiac hypertro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded4d232a133ff994fb823478089514e
https://doi.org/10.1016/j.bbrc.2014.02.014
https://doi.org/10.1016/j.bbrc.2014.02.014
Autor:
Herman Schreuder, Heike Enke, Matthias Schiell, Heike Di. Stump, Luigi Toti, Jörg Czech, Vasant Kumar, Alexander Liesum, Vincent Morrison, Timo H. J. Niedermeyer, Holger Hoffmann, Daniel B. Kramer, Christine Klemke-Jahn, Michael Kurz, Petra Lönze, Christopher Kallus, Mark Brönstrup, Armin Bauer
Publikováno v:
Scientific Reports
'Scientific Reports ', vol: 6, pages: 32958-1-32958-9 (2016)
'Scientific Reports ', vol: 6, pages: 32958-1-32958-9 (2016)
Mature thrombin activatable fibrinolysis inhibitor (TAFIa) is a carboxypeptidase that stabilizes fibrin clots by removing C-terminal arginines and lysines from partially degraded fibrin. Inhibition of TAFIa stimulates the degradation of fibrin clots
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bdd5b909e8f9ba27c50b07dc43e0ff0
https://hdl.handle.net/10033/621048
https://hdl.handle.net/10033/621048
Autor:
Armin Walser, Silke Herok, Uwe Heinelt, Peter-Michael Blohm, Hans Matter, Detlev Schneider, Volker Brachvogel, Petra Lönze, Alexander Liesum, Elisabeth Defossa, Andrea Müller, Herman Schreuder, Peter Wildgoose, Fahad Al-Obeidi
Publikováno v:
Journal of Medicinal Chemistry. 45:2749-2769
A series of 138 nonchiral 3-amidinobenzyl-1H-indole-2-carboxamides and analogues as inhibitors of the blood coagulation enzyme factor Xa (fXa) were designed, synthesized, and investigated by X-ray structure analysis and 3D quantitative structure-acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a726565af642ccfaba27630b1476d74a
https://doi.org/10.1021/jm0111346
https://doi.org/10.1021/jm0111346
Autor:
Milan Fábry, Anusch Peyman, Rolf Hilgenfeld, Alexander Liesum, Karl-Heinz Budt, Jochen Knolle, Juraj Sedlacek, Harald Berchtold, Gudrun Lange-Savage
Publikováno v:
European Journal of Biochemistry. 248:313-322
Human immunodeficiency virus 1 (HIV-1) protease is a prime target in the search for drugs to combat the AIDS virus. The enzyme functions as a C2-symmetric dimer, cleaving the gag and gag-pol viral polyproteins at distinct sites. The possession of a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eac75eb4346a1fc19081faa07511f50
https://doi.org/10.1111/j.1432-1033.1997.00313.x
https://doi.org/10.1111/j.1432-1033.1997.00313.x
Publikováno v:
Journal of Crystal Growth. 122:330-336
We have grown crystals of two bacterial enzymes, thermolysin fromBacillus thermoproteolyticus and a novel 23 kD lysozyme fromStreptomyces coelicolor, on the unmanned COSIMA-2 space mission. The crystals obtained under microgravity conditions were com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f59a74806f516d7cb87984d6f7722104
https://doi.org/10.1016/0022-0248(92)90265-k
https://doi.org/10.1016/0022-0248(92)90265-k
Publikováno v:
Biochemical and biophysical research communications. 329(3)
The crystal structure of human growth differentiation factor 5 (GDF5) was solved at 2.4 A resolution. The structure is very similar to the structure of bone morphogenetic factor 7 (BMP7) and consists of two banana-shaped monomers, linked via a disulf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83a6bc28b7adcdd9f093f72c4f4fd1fc
https://pubmed.ncbi.nlm.nih.gov/15752764
https://pubmed.ncbi.nlm.nih.gov/15752764
Autor:
Werner Aretz, Klaus Sauber, Wolfgang Kabsch, Karin Fritz-Wolf, Alexander Liesum, Gudrun Lange, Herman Schreuder, Klaus Peter Koller
Publikováno v:
Protein Science
Glutarylamidase is an important enzyme employed in the commercial production of 7-aminocephalosporanic acid, a starting compound in the synthesis of cephalosporin antibiotics. 7-aminocephalosporanic acid is obtained from cephalosporin C, a natural an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2067014d33485adda53fc9fbc299e4
Wiley Online Library
Wiley Online Library
Autor:
Corinna Lippmann, H.G. Wittmann, Winfried Hinrichs, Ada Yonath, Wolfram Saenger, Julia Hoven, Alexander Liesum, Volker A. Erdmann, Christoph W. Müller, Anke Müller-Fahrnow, Keith S. Wilson, Z. Dauter, Gabriela Weber, Martina Düvel, Andreas Plaas-Link, Christian Betzel, Rolf Hilgenfeld, Georg E. Schulz, Karin Stegen
Publikováno v:
FEBS Letters. 259:194-198
For the crystallization of proteins under microgravity conditions, a Chinese re-entry system was used, in which 101 experiments of 25 different biological macromolecules were accommodated. From the results obtained we conclude that under microgravity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a979eb09e90dd7e4b9d94903d8194b
https://doi.org/10.1016/0014-5793(89)81526-1
https://doi.org/10.1016/0014-5793(89)81526-1
Publikováno v:
FEBS Letters. (1-2):110-112
Both recombinant blood coagulation factor XIII a-chain and factor XIII isolated from human placenta have been crystallized using a novel robotic system for the automatic screening of crystallization conditions. The monoclinic and orthorhombic crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6285fc6d90a44fc50d63a6ca2052ce