Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Alexander Lepioshkin"'
Autor:
Thane Jones, Natalia Monakhova, Florence Guivel-Benhassine, Alexander Lepioshkin, Timothée Bruel, Thomas R. Lane, Olivier Schwartz, Ana C. Puhl, Vadim Makarov, Sean Ekins
Publikováno v:
ACS Omega, Vol 8, Iss 43, Pp 40817-40822 (2023)
Externí odkaz:
https://doaj.org/article/837556e13c3e4a1aa59e31dcd50f48c2
Autor:
Elena G. Salina, Umberto Postiglione, Laurent R. Chiarelli, Deborah Recchia, Monika Záhorszká, Alexander Lepioshkin, Natalia Monakhova, Adrian Pál, Alessio Porta, Giuseppe Zanoni, Jana Korduláková, Elena Kazakova, Davide Sassera, Maria Rosalia Pasca, Vadim Makarov, Giulia Degiacomi
Publikováno v:
mSphere, Vol 7, Iss 6 (2022)
ABSTRACT Tuberculosis (TB) still poses a global menace as one of the deadliest infectious diseases. A quarter of the human population is indeed latently infected with Mycobacterium tuberculosis. People with latent infection have a 5 to 10% lifetime r
Externí odkaz:
https://doaj.org/article/df59359de4744e088c1593f4deded2ce
Autor:
Olga Riabova, Anna Egorova, Alexander Lepioshkin, Yan Li, Kerstin Voigt, Florian Kloss, Vadim Makarov
Publikováno v:
ChemMedChem. 17
Thieno[2,3-d]pyrimidines represent a novel antibacterial prodrug scaffold, previously identified through a screening campaign against Mycobacterium tuberculosis in which the formation of highly antimycobacterial metabolites catalyzed by the nitroredu
Autor:
Vadim Makarov, Alexander Lepioshkin, Jeffrey Lin, Thomas J. Lane, Sean Ekins, Maureen J. Donlin, Olga B. Riabova, Evan Xu
Publikováno v:
ACS Medicinal Chemistry Letters. 12:774-781
Opportunistic infections from pathogenic fungi present a major challenge to healthcare because of a very limited arsenal of antifungal drugs, an increasing population of immunosuppressed patients, and increased prevalence of resistant clinical strain
Autor:
Eva Repková, Jaroslav Roh, Júlia Zemanová, Jana Korduláková, Natalia Monakhova, Jozef Nosek, Maria Rosalia Pasca, Anna Egorova, Josè Camilla Sammartino, Giulia Degiacomi, Vadim Makarov, Elena G. Salina, Renáta Górová, Anthony Vocat, Alexander Lepioshkin, Katarína Mikušová, Helena Jurdáková, Stewart T. Cole
Publikováno v:
ACS Infectious Diseases. 7:88-100
Latent Mycobacterium tuberculosis infection presents one of the largest challenges for tuberculosis control and novel antimycobacterial drug development. A series of pyrano[3,2-b]indolone-based compounds was designed and synthesized via an original e
Autor:
Natalia, Monakhova, Jana, Korduláková, Anthony, Vocat, Anna, Egorova, Alexander, Lepioshkin, Elena G, Salina, Jozef, Nosek, Eva, Repková, Júlia, Zemanová, Helena, Jurdáková, Renáta, Górová, Jaroslav, Roh, Giulia, Degiacomi, José Camilla, Sammartino, Maria Rosalia, Pasca, Stewart T, Cole, Katarína, Mikušová, Vadim, Makarov
Publikováno v:
ACS infectious diseases. 7(1)
Latent
Autor:
Paola Brocca, Silvia Buroni, Laurent R. Chiarelli, Fabiana Quaglia, Agnese Miro, Isabelle Grillo, Alexander Lepioshkin, Tom Coenye, Valeria Rondelli, Vadim Makarov, Svetlana Savina, Gabriella Costabile, Alberto Azzalin, Francesca Ungaro, Viola Camilla Scoffone, Giovanna Riccardi, Thomas Zinn, Romina Provenzano
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
'Nanomedicine: Nanotechnology, Biology and Medicine ', vol: 23, pages: 102113-1-102113-12 (2020)
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
'Nanomedicine: Nanotechnology, Biology and Medicine ', vol: 23, pages: 102113-1-102113-12 (2020)
C109 is a potent but poorly soluble FtsZ inhibitor displaying promising activity against Burkholderia cenocepacia, a high-risk pathogen for cystic fibrosis (CF) sufferers. To harness C109 for inhalation, we developed nanocrystal-embedded dry powders
Autor:
Josè Camilla Sammartino, Giorgia Mori, Martin Forbak, Maria Rosalia Pasca, Olga Riabova, Laurent R. Chiarelli, Giulia Degiacomi, Artem Grigorov, Alexander Lepioshkin, Katarína Mikušová, Giovanna Riccardi, Beatrice Silvia Orena, Tatyana L. Azhikina, Fabio Gosetti, Vadim Makarov, Marcello Manfredi, Jana Korduláková, Emilio Marengo, Arianna Buzzi, Elena G. Salina, Jan Madacki
The thienopyrimidine TP053 is an antitubercular prodrug active against both replicating and nonreplicating Mycobacterium tuberculosis (M. tuberculosis) cells, which requires activation by the mycothiol-dependent nitroreductase Mrx2. The investigation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1088bb5004f60e105b1d837e21de70
http://hdl.handle.net/10281/253275
http://hdl.handle.net/10281/253275
Autor:
M. O. Shleeva, Alexander Lepioshkin, Olga Riabova, Arseny S. Kaprelyants, Galina R. Demina, Vadim Makarov, Vadim D. Nikitushkin
Publikováno v:
Annals of Clinical Microbiology and Antimicrobials, Vol 16, Iss 1, Pp 1-9 (2017)
Annals of Clinical Microbiology and Antimicrobials
Annals of Clinical Microbiology and Antimicrobials
Background Resuscitation promoting factors (Rpfs) are the proteins involved in the process of reactivation of the dormant cells of mycobacteria. Recently a new class of nitrophenylthiocyanates (NPTs), capable of inhibiting the biological and enzymati
Autor:
Katarína Mikušová, Fabio Gosetti, Vadim Makarov, Giovanna Riccardi, Elena A. Salina, Giorgio Mori, Alexander Lepioshkin, Jan Madacki, Emilio Marengo, Martin Forbak, Jana Korduláková, Arianna Buzzi, Beatrice Silvia Orena, Olga Riabova, Tatyana L. Azhikina, Laurent R. Chiarelli, Artyom Grigorov, Maria Rosalia Pasca, Marcello Manfredi, Giulia Degiacomi
Publikováno v:
SSRN Electronic Journal.
The thienopyrimidine TP053 is an antitubercular prodrug active against both replicating and non-replicating Mycobacterium tuberculosis cells. Its mechanism of activation involves the reduction of a NO2 group by the mycothiol-dependent reductase Mrx2,