Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Alexander Lemak"'
Autor:
Rachel J. Harding, Justin C. Deme, Johannes F. Hevler, Sem Tamara, Alexander Lemak, Jeffrey P. Cantle, Magdalena M. Szewczyk, Nola Begeja, Siobhan Goss, Xiaobing Zuo, Peter Loppnau, Alma Seitova, Ashley Hutchinson, Lixin Fan, Ray Truant, Matthieu Schapira, Jeffrey B. Carroll, Albert J. R. Heck, Susan M. Lea, Cheryl H. Arrowsmith
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Harding et al. present a biophysical and structural characterization of the complex between huntingtin (HTT) and HAP40 proteins. They show that the abundance of HAP40 is coupled with that of HTT and that there is greater conformational variety in the
Externí odkaz:
https://doaj.org/article/eb1fd59dd9ce42829c1dde1a83e58ffc
Autor:
Amélie Wallenhammar, Madhanagopal Anandapadamanaban, Alexander Lemak, Claudio Mirabello, Patrik Lundström, Björn Wallner, Maria Sunnerhagen
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181551 (2017)
Tripartite motif-containing (TRIM) proteins are defined by the sequential arrangement of RING, B-box and coiled-coil domains (RBCC), where the B-box domain is a unique feature of the TRIM protein family. TRIM21 is an E3 ubiquitin-protein ligase impli
Externí odkaz:
https://doaj.org/article/e6dffc08507d4cc0b53085613b906eca
Autor:
Alexander Eletsky, Karolina Michalska, Scott Houliston, Qi Zhang, Michael D Daily, Xiaohui Xu, Hong Cui, Adelinda Yee, Alexander Lemak, Bin Wu, Maite Garcia, Meagan C Burnet, Kristen M Meyer, Uma K Aryal, Octavio Sanchez, Charles Ansong, Rong Xiao, Thomas B Acton, Joshua N Adkins, Gaetano T Montelione, Andrzej Joachimiak, Cheryl H Arrowsmith, Alexei Savchenko, Thomas Szyperski, John R Cort
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101787 (2014)
Bacterial species in the Enterobacteriaceae typically contain multiple paralogues of a small domain of unknown function (DUF1471) from a family of conserved proteins also known as YhcN or BhsA/McbA. Proteins containing DUF1471 may have a single or th
Externí odkaz:
https://doaj.org/article/86d6bee1feac4e90bbb12b0e86a9a3f7
Autor:
Alexander Lemak, Adelinda Yee, Hong Wu, Damian Yap, Hong Zeng, Ludmila Dombrovski, Scott Houliston, Samuel Aparicio, Cheryl H Arrowsmith
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77020 (2013)
Mixed Lineage Leukemia 5 (MLL5) is a histone methyltransferase that plays a key role in hematopoiesis, spermatogenesis and cell cycle progression. In addition to its catalytic domain, MLL5 contains a PHD finger domain, a protein module that is often
Externí odkaz:
https://doaj.org/article/b06acf9d1d7d4120b22de65f3d883735
Autor:
Bin Wu, Tatiana Skarina, Adelinda Yee, Marie-Claude Jobin, Rosa Dileo, Anthony Semesi, Christophe Fares, Alexander Lemak, Brian K Coombes, Cheryl H Arrowsmith, Alexander U Singer, Alexei Savchenko
Publikováno v:
PLoS Pathogens, Vol 6, Iss 6, p e1000960 (2010)
NleG homologues constitute the largest family of Type 3 effectors delivered by pathogenic E. coli, with fourteen members in the enterohaemorrhagic (EHEC) O157:H7 strain alone. Identified recently as part of the non-LEE-encoded (Nle) effector set, thi
Externí odkaz:
https://doaj.org/article/3b9118a42dbf4d48b24866eb01163934
Autor:
Tae-Eun Kim, Kotaro Tsuboyama, Scott Houliston, Cydney M. Martell, Claire M. Phoumyvong, Alexander Lemak, Hugh K. Haddox, Cheryl H. Arrowsmith, Gabriel J. Rocklin
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Designing entirely new protein structures remains challenging because we do not fully understand the biophysical determinants of folding stability. Yet some protein folds are easier to design than others. Previous work identified the 43-residue □β
Autor:
Brandon J. Payliss, Ying Wah E. Tse, Sean E. Reichheld, Alexander Lemak, Hwa Young Yun, Scott Houliston, Ayushi Patel, Cheryl H. Arrowsmith, Simon Sharpe, Haley D.M. Wyatt
Publikováno v:
Cell reports. 41(4)
The DNA repair scaffold SLX4 has multifaceted roles in genome stability, many of which depend on structure-selective endonucleases. SLX4 coordinates the cell cycle-regulated assembly of SLX1, MUS81-EME1, and XPF-ERCC1 into a tri-nuclease complex call
Autor:
Yong Wei, Cornelia Redel, Alexandra Ahlner, Alexander Lemak, Isak Johansson-Åkhe, Scott Houliston, Tristan M G Kenney, Aaliya Tamachi, Vivian Morad, Shili Duan, David W Andrews, Björn Wallner, Maria Sunnerhagen, Cheryl H Arrowsmith, Linda Z Penn
Publikováno v:
Nucleic Acids Res
Despite MYC dysregulation in most human cancers, strategies to target this potent oncogenic driver remain an urgent unmet need. Recent evidence shows the PP1 phosphatase and its regulatory subunit PNUTS control MYC phosphorylation, chromatin occupanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f19d6ab1ba39214c07c185c458d1acd
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-183749
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-183749
Autor:
Yong Wei, Alexandra Ahlner, Cornelia Redel, Alexander Lemak, Isak Johansson-Åkhe, Scott Houliston, Tristan M.G. Kenney, Aaliya Tamachi, Vivian Morad, Shili Duan, David W. Andrews, Björn Wallner, Maria Sunnerhagen, Cheryl H. Arrowsmith, Linda Z. Penn
SummaryDespite MYC dysregulation in most human cancers, strategies to target this potent oncogenic driver remains an urgent unmet need. Recent evidence shows the PP1 phosphatase and its regulatory subunit PNUTS control MYC phosphorylation and stabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::196bac29f7af7fbf7233005f9c21d78e
https://doi.org/10.1101/2021.12.02.470928
https://doi.org/10.1101/2021.12.02.470928
Autor:
Matthieu Schapira, Alexander Lemak, Alma Seitova, Justin C. Deme, Peter Loppnau, Cheryl H. Arrowsmith, Ashley Hutchinson, Sem Tamara, Rachel Harding, Albert J. R. Heck, Susan M. Lea, Jeffrey P. Cantle, Xiaobing Zuo, Magdalena M. Szewczyk, Johannes F. Hevler, Jeffrey B. Carroll, Lixin Fan
Huntington’s disease results from expansion of a glutamine-coding CAG tract in the huntingtin (HTT) gene, producing an aberrantly functioning form of HTT. Both wildtype and disease-state HTT form a hetero-dimer with HAP40 of unknown functional rele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10857a91400adeb011200148bab1c39c
https://doi.org/10.1101/2021.04.02.438217
https://doi.org/10.1101/2021.04.02.438217