Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Alexander L. Watters"'
Autor:
Mark Cartwright, Martin Rottman, Nathan I. Shapiro, Benjamin Seiler, Patrick Lombardo, Nazita Gamini, Julie Tomolonis, Alexander L. Watters, Anna Waterhouse, Dan Leslie, Dana Bolgen, Amanda Graveline, Joo H. Kang, Tohid Didar, Nikolaos Dimitrakakis, David Cartwright, Michael Super, Donald E. Ingber
Publikováno v:
EBioMedicine, Vol 9, Iss C, Pp 217-227 (2016)
Background: Blood cultures, and molecular diagnostic tests that directly detect pathogen DNA in blood, fail to detect bloodstream infections in most infected patients. Thus, there is a need for a rapid test that can diagnose the presence of infection
Externí odkaz:
https://doaj.org/article/b480f6acc7b148be903892a421baa371
Autor:
Anna Herland, Maximilian A. Benz, Olivier Y.F. Henry, Eric V. Shusta, Nur Mustafaoglu, Tae-Eun Park, Alexander L. Watters, Ryan M Hasselkus, Henry Sanchez, Edward A. FitzGerald, Sean P. Palecek, Robert Mannix, Hannah W. Song, Rachelle Prantil-Baun, Liliana Goumnerova, Heather J. McCrea, Donald E. Ingber
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
The high selectivity of the human blood-brain barrier (BBB) restricts delivery of many pharmaceuticals and therapeutic antibodies to the central nervous system. Here, we describe an in vitro microfluidic organ-on-a-chip BBB model lined by induced plu
Autor:
Thomas Serwold, Stephan Kissler, Sarah A. Vermillion, Sandeep T. Koshy, Omar Abdel-Rahman Ali, David J. Mooney, Martin A. Thelin, Frederic Vigneault, Alexander L. Watters, Des White
Publikováno v:
Diabetes. 66:2220-2229
Dysfunctional T cells can mediate autoimmunity, but the inaccessibility of autoimmune tissues and the rarity of autoimmune T cells in the blood hinder their study. We describe a method to enrich and harvest autoimmune T cells in vivo by using a bioma
Autor:
Donald E. Ingber, Heather J. McCrea, Henry Sanchez, Liliana Goumnerova, Anna Herland, Maximilian A. Benz, Olivier Y.F. Henry, Robert Mannix, Ryan M Hasselkus, Edward A. FitzGerald, Nur Mustafaoglu, Sean P. Palecek, Tae-Eun Park, Rachelle Prantil-Baun, Hannah W. Song, Eric V. Shusta, Alexander L. Watters
The highly specialized human brain microvascular endothelium forms a selective blood-brain barrier (BBB) with adjacent pericytes and astrocytes that restricts delivery of many pharmaceuticals and therapeutic antibodies to the central nervous system.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c844e17b58a09d2b590b47eb326358
Autor:
Alexander L. Watters, Benjamin T. Seiler, Dana Bolgen, Amanda R. Graveline, Tohid F. Didar, Michael Super, Martin Rottman, Nikolaos Dimitrakakis, David Cartwright, Daniel C. Leslie, Nathan I. Shapiro, Anna Waterhouse, Joo H. Kang, Donald E. Ingber, Patrick Lombardo, Mark Cartwright, Julie A. Tomolonis, Nazita Gamini
Publikováno v:
EBioMedicine, Vol 9, Iss C, Pp 217-227 (2016)
EBioMedicine
EBioMedicine
Background Blood cultures, and molecular diagnostic tests that directly detect pathogen DNA in blood, fail to detect bloodstream infections in most infected patients. Thus, there is a need for a rapid test that can diagnose the presence of infection
Autor:
Amanda Jiang, Donald E. Ingber, Akiko Mammoto, Alexander L. Watters, Elisabeth Jiang, Yu-Suke Torisawa, Tadanori Mammoto, Anthony Bahinski
Publikováno v:
Tissue Engineering Part C: Methods. 22:509-515
Studies on hematopoiesis currently rely on animal models because in vitro culture methods do not accurately recapitulate complex bone marrow physiology. We recently described a bone marrow-on-a-chip microfluidic device that enables the culture of liv
Autor:
Donald E. Ingber, Feng Huang, Sujatha R Thundivalappil, Nathan Brinkman, Michael Super, Tian Lin, Alexander L. Watters, H. Shaw Warren, Ann Smith, Jialin Liu, Tjitske S R van Engelen, Frank E. Riley
Publikováno v:
Molecular Medicine, Vol 22, Iss 1, Pp 22-31 (2016)
Molecular medicine (Cambridge, Mass.), 22, 22-31. Feinstein Institute for Medical Research
Molecular medicine (Cambridge, Mass.), 22, 22-31. Feinstein Institute for Medical Research
Infusion of the heme-binding protein hemopexin has been proposed as a novel approach to decrease heme-induced inflammation in settings of red blood cell breakdown, but questions have been raised as to possible side effects related to protease activit
Autor:
Joo H. Kang, Michael Super, Bissrat Melakeberhan, Akiko Mammoto, Alexander L. Watters, Harry Driscoll, Alexander Diaz, Donald E. Ingber
Publikováno v:
Advanced Biosystems. 1
Autor:
Joo H. Kang, Melissa Rodas, Howard A. Stone, Alexander Diaz, Alexander L. Watters, Harry Driscoll, Karel Domansky, Eujin Um, Donald E. Ingber, Michael Super
Publikováno v:
Small (Weinheim an der Bergstrasse, Germany). 11(42)
Magnetic nanoparticles have been employed to capture pathogens for many biological applications; however, optimal particle sizes have been determined empirically in specific capturing protocols. Here, a theoretical model that simulates capture of bac
Autor:
Daniel C. Leslie, Tohid F. Didar, Michael Super, Amanda R. Graveline, Patrick Lombardo, Tadanori Mammoto, Martin Rottman, Elisabet I. Qendro, Mark Cartwright, Alexander L. Watters, Anna Waterhouse, Joo H. Kang, Benjamin T. Seiler, Nazita Gamini, Melissa Rodas, Donald E. Ingber
Publikováno v:
Biomaterials. 67
Here we describe development of an extracorporeal hemoadsorption device for sepsis therapy that employs commercially available polysulfone or polyethersulfone hollow fiber filters similar to those used clinically for hemodialysis, covalently coated w