Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alexander L. Markowitz"'
Autor:
Peyton J. Tebon, Bowen Wang, Alexander L. Markowitz, Ardalan Davarifar, Brandon L. Tsai, Patrycja Krawczuk, Alfredo E. Gonzalez, Sara Sartini, Graeme F. Murray, Huyen Thi Lam Nguyen, Nasrin Tavanaie, Thang L. Nguyen, Paul C. Boutros, Michael A. Teitell, Alice Soragni
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract High throughput drug screening is an established approach to investigate tumor biology and identify therapeutic leads. Traditional platforms use two-dimensional cultures which do not accurately reflect the biology of human tumors. More clini
Externí odkaz:
https://doaj.org/article/cdb49d87278049f08e97471afd0ff5af
Autor:
Alexander L Markowitz, Radha Kalluri
Publikováno v:
eLife, Vol 9 (2020)
Sound intensity is encoded by auditory neuron subgroups that differ in thresholds and spontaneous rates. Whether variations in neuronal biophysics contributes to this functional diversity is unknown. Because intensity thresholds correlate with synapt
Externí odkaz:
https://doaj.org/article/a67cb4f8b8c2429f8726f0b83642d8e9
Autor:
Louise Menendez, Talon Trecek, Suhasni Gopalakrishnan, Litao Tao, Alexander L Markowitz, Haoze V Yu, Xizi Wang, Juan Llamas, Chichou Huang, James Lee, Radha Kalluri, Justin Ichida, Neil Segil
Publikováno v:
eLife, Vol 9 (2020)
The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to numerous genetic and environmental insults. In mammals, hair cells lack regenerative capacity, and their death leads to permanent hearing loss and vestibular dysfu
Externí odkaz:
https://doaj.org/article/6c860cc9943b4f488fa43d0ff80850e3
Autor:
Bowen Wang, Peyton J. Tebon, Alexander L. Markowitz, Graeme F. Murray, Huyen Nguyen, Nasrin Tavanaie, Thang L. Nguyen, Paul C. Boutros, Alice Soragni, Michael A. Teitell
Publikováno v:
Interferometry XXI.
Autor:
Bowen Wang, Peyton J. Tebon, Alexander L. Markowitz, Graeme F. Murray, Huyen Thi Lam Nguyen, Nasrin Tavanaie, Thang L. Nguyen, Paul C. Boutros, Alice Soragni, Michael A. Teitell
Publikováno v:
Conference on Lasers and Electro-Optics.
We develop a method to apply a high-throughput quantitative phase imaging-based assay to functional biomass accumulation measurements of 3D tumor organoids with single-organoid resolution, and demonstrate its utility for drug screening and therapy se
Autor:
Peyton J. Tebon, Bowen Wang, Alexander L. Markowitz, Ardalan Davarifar, Patrycja Krawczuk, Graeme Murray, Huyen Thi Lam Nguyen, Nasrin Tavanaie, Thang L. Nguyen, Paul C. Boutros, Michael A. Teitell, Alice Soragni
High-throughput drug screening is an established approach to investigate tumor biology and identify therapeutic leads. Traditional platforms for high-throughput screening use two-dimensional cultures of immortalized cell lines which do not accurately
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ff57eb5b117e3bcd315fb7c927b6dbc
https://doi.org/10.1101/2021.10.03.462896
https://doi.org/10.1101/2021.10.03.462896
Autor:
Peyton J. Tebon, Bowen Wang, Alexander L. Markowitz, Graeme Murray, Ardalan Davarifar, Huyen T. Nguyen, Nasrin Tavanaie, Thang L. Nguyen, Paul C. Boutros, Michael A. Teitell, Alice Soragni
Publikováno v:
Cancer Research. 82:3081-3081
As interest grows in using tumor organoids as models for drug discovery and precision medicine, platforms for the reliable functional testing and analysis of these organoids are needed. Existing functional approaches in precision medicine face diffic
Autor:
Radha Kalluri, Alexander L Markowitz
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
Sound intensity is encoded by auditory neuron subgroups that differ in thresholds and spontaneous rates. Whether variations in neuronal biophysics contributes to this functional diversity is unknown. Because intensity thresholds correlate with synapt
Autor:
Chichou Huang, Suhasni Gopalakrishnan, Neil Segil, Louise Menendez, Litao Tao, Juan Llamas, Justin K. Ichida, Haoze V Yu, Alexander L Markowitz, Radha Kalluri, Xizi Wang, James Lee, Talon Trecek
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to numerous genetic and environmental insults. In mammals, hair cells lack regenerative capacity, and their death leads to permanent hearing loss and vestibular dysfu