Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Alexander L. Dent"'
Autor:
D. Alejandro Canaria, Maia G. Clare, Bingyu Yan, Charlotte B. Campbell, Zachariah A. Ismaio, Nicole L. Anderson, Sungtae Park, Alexander L. Dent, Majid Kazemian, Matthew R. Olson
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IL-9-producing CD4+ T helper cells, termed Th9 cells, differentiate from naïve precursor cells in response to a combination of cytokine and cell surface receptor signals that are elevated in inflamed tissues. After differentiation, Th9 cells accumul
Externí odkaz:
https://doaj.org/article/f8a357bbff2a4fd8819701a96855a258
Autor:
Yuhong Chen, Mei Yu, Yongwei Zheng, Guoping Fu, Gang Xin, Wen Zhu, Lan Luo, Robert Burns, Quan-Zhen Li, Alexander L. Dent, Nan Zhu, Weiguo Cui, Laurent Malherbe, Renren Wen, Demin Wang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
B cell response and antibody production are generally facilitated by CD4+ follicular helper (Tfh) cells. Here the authors identify a subset of CXCR5+PD1+CD8+ Tfh cells that is normally suppressed by STAT5 signaling, so that STAT5 deficiency in mice i
Externí odkaz:
https://doaj.org/article/3b58b83ee76b4ab8925812d290639692
Autor:
Rachael Keating, Jenny L. Johnson, David C. Brice, Jocelyn G. Labombarde, Alexander L. Dent, Maureen A. McGargill
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT Enhancing the generation of broadly reactive antibodies against influenza A virus (IAV) is a pertinent goal toward developing a universal IAV vaccine. While antibodies that bind conserved IAV epitopes have been identified in humans, antibodi
Externí odkaz:
https://doaj.org/article/5b32c45fd4eb4b00b07f17f7bdc5be4e
Autor:
Victor H. Carpio, Florentin Aussenac, Lucinda Puebla-Clark, Kyle D. Wilson, Alejandro V. Villarino, Alexander L. Dent, Robin Stephens
Publikováno v:
iScience, Vol 23, Iss 7, Pp 101310- (2020)
Summary: Hybrid Th1/Tfh cells (IFN-γ+IL-21+CXCR5+) predominate in response to several persistent infections. In Plasmodium chabaudi infection, IFN-γ+ T cells control parasitemia, whereas antibody and IL-21+Bcl6+ T cells effect final clearance, sugg
Externí odkaz:
https://doaj.org/article/b487e74dccc04a409f18f5c68412ec2a
Autor:
Kristin Hollister, Praveen Kusumanchi, Ruth Ann Ross, Kristina Chandler, AdePeju Oshodi, Laura Heathers, Sean Teagarden, Li Wang, Alexander L. Dent, Suthat Liangpunsakul
Publikováno v:
Liver Research, Vol 2, Iss 1, Pp 52-59 (2018)
Background: Excessive drinkers (ED) and patients with alcoholic liver disease (ALD) are several times more susceptible to bacterial and viral infections and have a decrease in antibody responses to vaccinations. Follicular helper T (TFH) cells are es
Externí odkaz:
https://doaj.org/article/4c1c3d4badf94876a7624f72505c2918
Autor:
Markus M. Xie, Alexander L. Dent
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Follicular helper T (Tfh) cells are necessary for germinal center (GC) formation and within the GC, provide key signals to B cells for their differentiation into plasmablasts and plasma cells that secrete high-affinity and isotype-switched antibody (
Externí odkaz:
https://doaj.org/article/9888737041a6431cb23dc4821af5d7f7
Autor:
Alexis S Dadelahi, Mostafa F N Abushahba, Bárbara Ponzilacqua-Silva, Catherine A Chambers, Charles R Moley, Carolyn A Lacey, Alexander L Dent, Jerod A Skyberg
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011672 (2023)
Brucellosis, caused by facultative, intracellular Brucella spp., often results in chronic and/or lifelong infection. Therefore, Brucella must employ mechanisms to subvert adaptive immunity to cause chronic infection. B lymphocytes enhance susceptibil
Externí odkaz:
https://doaj.org/article/44ea05f424284566a1173f4ca08e2b85
Autor:
Fang Ke, Zachary L Benet, Mitra P Maz, Jianhua Liu, Alexander L Dent, Joanne Michelle Kahlenberg, Irina L Grigorova
Publikováno v:
eLife, Vol 12 (2023)
Follicular regulatory T cells (Tfr) restrict development of autoantibodies and autoimmunity while supporting high-affinity foreign antigen-specific humoral response. However, whether Tfr can directly repress germinal center (GC) B cells that acquire
Externí odkaz:
https://doaj.org/article/859bb3259706499e8d6e931c50a4ed50
Publikováno v:
The Journal of Immunology. 210:905-915
High-affinity allergen-specific IgE is essential for the severe allergic anaphylaxis response. High-affinity Abs are formed by successive rounds of selection of Ag-specific B cells in the germinal center (GC); however, several studies have shown that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2435e280e007c7362c9dda367ee4f71c
https://doi.org/10.4049/jimmunol.2200521
https://doi.org/10.4049/jimmunol.2200521
Autor:
Benjamin Van Court, Jacob Gadwa, Diemmy Nguyen, Shiv Bhuvane, Thomas E. Bickett, Laurel L. Lenz, Shilpa Bhatia, Laurel B. Darragh, Ayman Oweida, Alexander L. Dent, Michael W. Knitz, Miles Piper, Andy Phan, Sana D. Karam, Tiffany T. Pham, Sophia Corbo
Publikováno v:
Mol Ther
STAT3 signaling has been shown to regulate cellular function and cytokine production in the tumor microenvironment (TME). Within the head and neck squamous cell carcinoma (HNSCC) TME, we previously showed that therapeutic targeting of STAT3 in combin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a883b5f80a0b774060ff79a508868af
https://doi.org/10.1016/j.ymthe.2021.11.011
https://doi.org/10.1016/j.ymthe.2021.11.011