Výsledky vyhledávání - "Alexander L Johnson"

Synthesis and antiplatelet activity of DMP 757 analogs

Autor: Shaker A. Mousa, Alexander L. Johnson, Anju Parthasarathy, Gregory James Wells, John M. Fevig, Ruth R. Wexler, William F. DeGrado, John Wityak, Sharon A. Jackson

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:2097-2100

A series of novel cyclic peptides related to DMP 757 bearing heterocyclic and otherwise modified linking moieties were prepared by solution-phase methods. Synthetic methods for the preparation of linking groups and cyclic peptides are presented. In v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cad6b8048d2fed6f8d757479f42a4ba1
https://doi.org/10.1016/0960-894x(95)00351-s

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Acyl CoA:Cholesterol Acyltransferase (ACAT) Inhibitors: Synthesis and Structure-Activity Relationship Studies of a New Series of Trisubstituted Imidazoles

Autor: Peter J. Gillies, C. Anne Higley, Pennio Pennev, Alexander L. Johnson, Candy S. Robinson, Richard G. Wilde, Thomas P. Maduskuie, Jeffrey T. Billheimer, Ruth R. Wexler

Publikováno v: Journal of Medicinal Chemistry. 37:3511-3522

A series of 4,5-diaryl-2-(substituted thio)-1H-imidazoles has been synthesized and demonstrated to be potent inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). The design, synthesis, and structure-activity relationships for this series are re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384606c84f7d1f655086b272c98237d8
https://doi.org/10.1021/jm00047a009

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Novel ether derivatives of alkyl piperidines as potential sigma / 5HT2 antipsychotic agents

Autor: Thomas E. Christos, Alexander L. Johnson, Gary A. Cain, William K. Schmidt, S. William Tam

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:2347-2352

A series of novel cinnamyl and propargyl ether derivatives of alkyl piperidines which show high affinity for sigma and 5HT 2 receptors are described. The ligands exhibit high selectivities for these receptors over D 2 as well as good activity in vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::460a9d90612531a2617217b18b4d5eb2
https://doi.org/10.1016/0960-894x(94)85038-0

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Novel conformationally restricted aromatic piperidines as selective sigma receptor ligands

Autor: D. E. Grigoriadis, Paul J. Gilligan, Alexander L. Johnson, Gary A. Cain, S. William Tam, Charles J. Eyermann, Thomas E. Christos

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:329-334

A series of novel conjugated aromatic 4-amino- and 4-amido-piperidines which are potent sigma receptor ligands are described. These ligands exhibited good to excellent selectivities for binding at sigma versus D2 and 5-HT2 receptors.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f671b10ed60a67a358c3a3049c6b33a
https://doi.org/10.1016/s0960-894x(01)80138-4

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Neurotensin receptor binding and antinociceptive activity for lipophilic Nα-amido neurotensin(9–13) analogs

Autor: Gary A. Cain, Alexander L. Johnson, Pat N. Confalone, Richard S. Pottorf, S. William Tam, William K. Schmidt, Thomas E. Christos

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 3:2055-2060

A series of lipophilic Nα-amido-neurotensin(9–13) analogs was prepared. These acylated pentapeptides exhibited good neurotensin receptor binding, as well as in vivo analgesic activity via i.c.v. and even intravenous routes of administration.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::179b51d6bf812a835d140780028b2b81
https://doi.org/10.1016/s0960-894x(01)81014-3

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Identification of simpler analogs of neurotensin(9–13) which retain antinociceptive activity

Autor: S.William Tam, Alexander L. Johnson, Richard S. Pottorf, Gary Avonn Cain, Thomas Eugene Christos, William K. Schmidt

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 3:1767-1772

The neurotensin C-terminal pentapeptide has been systematically simplified to identify a minimal fragment with in vivo analgesic activity and neurotensin receptor binding ability. Di-, tri-, and tetrapeptide fragments were inactive. Pentapeptide simp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::610c15ae823203498b2048c151083614
https://doi.org/10.1016/s0960-894x(00)80059-1

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Stable isosteres of neurotensin c-terminal pentapeptides derived by modification of the amide function

Autor: Alexander L. Johnson, William K. Schmidt, S. William Tam, Thomas E. Christos, Argyrios G. Arvanitis, Richard S. Pottorf, Gary A. Cain

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 3:1035-1040

A series of amide bond modified neurotensin c-terminal pentapeptides has been prepared and tested for their in vivo analgesic properties. Reduced amide function and trans double bond isosteres did show analgesic activity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::885d84d0bd95f8617d4d25a187397f34
https://doi.org/10.1016/s0960-894x(00)80282-6

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The preparation of (perfluoroalkyl)imidazoles as nonpeptide angiotensin II receptor antagonists

Autor: Andrew T. Chiu, Pieter B.M.W.M. Timmermans, Alexander L. Johnson, Pancras C. Wong, David J. Carini, Ruth R. Wexler

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 3:895-898

A series of (perfluoroalkyl)imidazoles have been prepared and are potent angiotensin II antagonists. One of these compounds, DuP 532, 4-pentafluoroethyl-2-propyl-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole-5-carboxylic acid, is a select

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f11bef201ae39dd552c2a8617911e51f
https://doi.org/10.1016/s0960-894x(00)80688-5

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