Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Alexander L, Perryman"'
Publikováno v:
ACS Omega, Vol 5, Iss 27, Pp 16562-16567 (2020)
Externí odkaz:
https://doaj.org/article/1fb17f7ad8894d7ebd5513c0889e73b3
Autor:
Monica Bubenik, Pavel Mader, Philippe Mochirian, Fréderic Vallée, Jillian Clark, Jean-François Truchon, Alexander L. Perryman, Victor Pau, Igor Kurinov, Karl E. Zahn, Marie-Eve Leclaire, Robert Papp, Marie-Claude Mathieu, Martine Hamel, Nicole M. Duffy, Claude Godbout, Matias Casas-Selves, Jean-Pierre Falgueyret, Prasamit S. Baruah, Olivier Nicolas, Rino Stocco, Hugo Poirier, Giovanni Martino, Alexanne Bonneau Fortin, Anne Roulston, Amandine Chefson, Stéphane Dorich, Miguel St-Onge, Purvish Patel, Charles Pellerin, Stéphane Ciblat, Thomas Pinter, Francis Barabé, Majida El Bakkouri, Paranjay Parikh, Christian Gervais, Agnel Sfeir, Yael Mamane, Stephen J. Morris, W. Cameron Black, Frank Sicheri, Michel Gallant
Publikováno v:
Journal of Medicinal Chemistry. 65:13198-13215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::947c93bf7b6803db8ed4beb935e92af5
https://doi.org/10.1021/acs.jmedchem.2c00998
https://doi.org/10.1021/acs.jmedchem.2c00998
Autor:
Pradeep Kumar, Glenn C. Capodagli, Divya Awasthi, Riju Shrestha, Karishma Maharaja, Paridhi Sukheja, Shao-Gang Li, Daigo Inoyama, Matthew Zimmerman, Hsin Pin Ho Liang, Jansy Sarathy, Marizel Mina, George Rasic, Riccardo Russo, Alexander L. Perryman, Todd Richmann, Aditi Gupta, Eric Singleton, Sheetal Verma, Seema Husain, Patricia Soteropoulos, Zhe Wang, Roxanne Morris, Gene Porter, Gautam Agnihotri, Padmini Salgame, Sean Ekins, Kyu Y. Rhee, Nancy Connell, Véronique Dartois, Matthew B. Neiditch, Joel S. Freundlich, David Alland
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT We report GSK3011724A (DG167) as a binary inhibitor of β-ketoacyl-ACP synthase (KasA) in Mycobacterium tuberculosis. Genetic and biochemical studies established KasA as the primary target. The X-ray crystal structure of the KasA-DG167 compl
Externí odkaz:
https://doaj.org/article/8d6c465583e4410c8afdd48c4a9a3287
Autor:
Monica, Bubenik, Pavel, Mader, Philippe, Mochirian, Fréderic, Vallée, Jillian, Clark, Jean-François, Truchon, Alexander L, Perryman, Victor, Pau, Igor, Kurinov, Karl E, Zahn, Marie-Eve, Leclaire, Robert, Papp, Marie-Claude, Mathieu, Martine, Hamel, Nicole M, Duffy, Claude, Godbout, Matias, Casas-Selves, Jean-Pierre, Falgueyret, Prasamit S, Baruah, Olivier, Nicolas, Rino, Stocco, Hugo, Poirier, Giovanni, Martino, Alexanne Bonneau, Fortin, Anne, Roulston, Amandine, Chefson, Stéphane, Dorich, Miguel, St-Onge, Purvish, Patel, Charles, Pellerin, Stéphane, Ciblat, Thomas, Pinter, Francis, Barabé, Majida, El Bakkouri, Paranjay, Parikh, Christian, Gervais, Agnel, Sfeir, Yael, Mamane, Stephen J, Morris, W Cameron, Black, Frank, Sicheri, Michel, Gallant
Publikováno v:
Journal of medicinal chemistry. 65(19)
DNA polymerase theta (Polθ) is an attractive synthetic lethal target for drug discovery, predicted to be efficacious against breast and ovarian cancers harboring BRCA-mutant alleles. Here, we describe our hit-to-lead efforts in search of a selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::531f44b082fb5f00fe6c2f82d97a48bc
https://pubmed.ncbi.nlm.nih.gov/36126059
https://pubmed.ncbi.nlm.nih.gov/36126059
Autor:
Paridhi Sukheja, Pradeep Kumar, Nisha Mittal, Shao-Gang Li, Eric Singleton, Riccardo Russo, Alexander L. Perryman, Riju Shrestha, Divya Awasthi, Seema Husain, Patricia Soteropoulos, Roman Brukh, Nancy Connell, Joel S. Freundlich, David Alland
Publikováno v:
mBio, Vol 8, Iss 1 (2017)
ABSTRACT Active tuberculosis (TB) and latent Mycobacterium tuberculosis infection both require lengthy treatments to achieve durable cures. This problem has partly been attributable to the existence of nonreplicating M. tuberculosis “persisters”
Externí odkaz:
https://doaj.org/article/4063dfd78f48410f8cdd22b4c8e25ff7
Autor:
Alexander Lemenze, Nisha Mittal, Alexander L. Perryman, Samer S. Daher, Sean Ekins, James Occi, Yong-Mo Ahn, Xin Wang, Riccardo Russo, Jimmy S. Patel, Robin M. Daugherty, David O. Wood, Nancy Connell, Joel S. Freundlich
Publikováno v:
ACS Infect Dis
Rickettsia is a genus of Gram-negative bacteria that has for centuries caused large-scale morbidity and mortality. In recent years, the resurgence of rickettsial diseases as a major cause of pyrexias of unknown origin, bioterrorism concerns, vector m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de72eb51dc86b1a2b07680accd692ec0
https://europepmc.org/articles/PMC9912140/
https://europepmc.org/articles/PMC9912140/
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 10, p e0005023 (2016)
The Zika virus outbreak in the Americas has caused global concern. To help accelerate this fight against Zika, we launched the OpenZika project. OpenZika is an IBM World Community Grid Project that uses distributed computing on millions of computers
Externí odkaz:
https://doaj.org/article/8b480e73c407452eb166d1101c9feda4
Publikováno v:
ACS Omega
ACS Omega, Vol 5, Iss 27, Pp 16562-16567 (2020)
ACS Omega, Vol 5, Iss 27, Pp 16562-16567 (2020)
Solubility is a key metric for therapeutic compounds. Conversely, insoluble compounds cloud the accuracy of assays at all stages of chemical biology and drug discovery. Herein, we disclose naïve Bayesian classifier models to predict aqueous solubili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::806df416269cf0ca922142739eba188b
https://doi.org/10.1021/acsomega.0c01251
https://doi.org/10.1021/acsomega.0c01251
Autor:
Cíntia Bittar, Nathalya Cristina de Moraes Roso Mesquita, Bruna Katiele de Paula Sousa, Jacqueline Farinha Shimizu, Melina Mottin, Glaucius Oliva, Letícia Ribeiro de Assis, Mark Harris, Robinson Sabino-Silva, Sean Ekins, Paula Rahal, Alexander L. Perryman, Ana Carolina Gomes Jardim, Luis Octávio Regasini, Andres Merits, Débora Moraes de Oliveira, Luiz Ricardo Goulart, Carolina Horta Andrade, Suely da Silva
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Scientific Reports
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Made available in DSpace on 2020-12-11T03:29:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-11-27 Royal Society -Newton Advanced Fellowship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7047a99c3d511fdc5b5c5e9f5b49466f
http://link.springer.com/article/10.1038/s41598-019-54169-z
http://link.springer.com/article/10.1038/s41598-019-54169-z
Autor:
Shao-Gang Li, Alexander L. Perryman, Alex Lemenze, Sean Ekins, Steve D. Paget, Pradeep Kumar, Xin Wang, Thomas P. Stratton, Joel S. Freundlich, Arthur J. Olson
Publikováno v:
ACS Infectious Diseases. 5:2148-2163
Tuberculosis, caused by Mycobacterium tuberculosis (M. tuberculosis), kills 1.6 million people annually. To bridge the gap between structure- and cell-based drug discovery strategies, we are pionee...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b6e3505194ba3afaeb6a2674ce9ff0e
https://doi.org/10.1021/acsinfecdis.9b00295
https://doi.org/10.1021/acsinfecdis.9b00295